pI: 10.1318 |
Length (AA): 133 |
MW (Da): 13665 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129762)
Species | Accession | Gene Product |
---|---|---|
Chlamydia trachomatis | CT_070 | metal ABC transporter permease |
Chlamydia trachomatis | CT_417 | metal ABC transporter permease |
Escherichia coli | b1859 | zinc transporter subunit: membrane component of ABC superfamily |
Mycobacterium leprae | ML0335c | Possible ABC-transporter transmembrane protein |
Mycobacterium tuberculosis | Rv2060 | Possible conserved integral membrane protein |
Mycobacterium ulcerans | MUL_4149 | permease of an ABC-type transporter |
Treponema pallidum | TP0166 | ABC transporter, permease protein (troD) |
Treponema pallidum | TP0036 | ABC transporter, permease protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0175 | ABC-type Mn2+/Zn2+ transport system, permease component |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1859 | Escherichia coli | non-essential | goodall |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.