Detailed view for Rv2176

Basic information

TDR Targets ID: 981113
Mycobacterium tuberculosis, Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L)
Source Database / ID:  Tuberculist 

pI: 6.1836 | Length (AA): 399 | MW (Da): 42802 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 286 4ow8 (A) 3 282 41.00 0 1 1.24824 -0.94
18 360 3elj (A) 25 361 21.00 0 1 0.846749 0.27
114 219 2pml (X) 143 248 29.00 0.0000067 0.38 0.529364 -0.14
138 248 3aln (A) 225 327 52.00 0.00000046 0.04 -0.0701045 1.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126962)

Species Accession Gene Product
Mycobacterium tuberculosis Rv2176   Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L)
Mycobacterium ulcerans MUL_3519   Ser/Thr protein kinase
Trichomonas vaginalis TVAG_043090   CAMK family protein kinase
Trichomonas vaginalis TVAG_146860   CAMK family protein kinase
Trichomonas vaginalis TVAG_035660   CAMK family protein kinase
Trichomonas vaginalis TVAG_107960   CAMK family protein kinase
Trichomonas vaginalis TVAG_306560   CAMK family protein kinase
Trichomonas vaginalis TVAG_073890   STE family protein kinase
Trichomonas vaginalis TVAG_412230   CAMK family protein kinase
Trichomonas vaginalis TVAG_162130   AGC family protein kinase
Trichomonas vaginalis TVAG_125730   AGC family protein kinase
Trichomonas vaginalis TVAG_425590   CAMK family protein kinase
Trichomonas vaginalis TVAG_031280   CAMK family protein kinase
Trichomonas vaginalis TVAG_373830   mitogen activated protein kinase kinase 3, MAPKK3, mek3, putative
Trichomonas vaginalis TVAG_329380   CAMK family protein kinase
Trichomonas vaginalis TVAG_273320   CAMK family protein kinase
Trichomonas vaginalis TVAG_357230   TKL family protein kinase
Trichomonas vaginalis TVAG_175440   CAMK family protein kinase
Trichomonas vaginalis TVAG_157380   CAMK family protein kinase
Trichomonas vaginalis TVAG_251560   CAMK family protein kinase
Trichomonas vaginalis TVAG_219520   CAMK family protein kinase
Trichomonas vaginalis TVAG_156800   CAMK family protein kinase
Trichomonas vaginalis TVAG_073220   CAMK family protein kinase
Trichomonas vaginalis TVAG_006460   CAMK family protein kinase
Trichomonas vaginalis TVAG_203480   CAMK family protein kinase
Trichomonas vaginalis TVAG_383570   CAMK family protein kinase
Trichomonas vaginalis TVAG_073880   CAMK family protein kinase
Trichomonas vaginalis TVAG_383610   CAMK family protein kinase
Trichomonas vaginalis TVAG_595110   CAMK family protein kinase
Trichomonas vaginalis TVAG_361150   CAMK family protein kinase
Trichomonas vaginalis TVAG_088670   CAMK family protein kinase
Trichomonas vaginalis TVAG_373880   serine/threonine protein kinase, putative
Trichomonas vaginalis TVAG_064600   serine/threonine kinase, putative
Trichomonas vaginalis TVAG_175430   CAMK family protein kinase
Trichomonas vaginalis TVAG_041480   AGC family protein kinase
Trichomonas vaginalis TVAG_155690   CAMK family protein kinase
Trichomonas vaginalis TVAG_072560   CAMK family protein kinase
Trichomonas vaginalis TVAG_196960   CAMK family protein kinase
Trichomonas vaginalis TVAG_424150   CAMK family protein kinase
Trichomonas vaginalis TVAG_418510   CAMK family protein kinase
Trichomonas vaginalis TVAG_340120   CAMK family protein kinase
Trichomonas vaginalis TVAG_284560   CAMK family protein kinase
Trichomonas vaginalis TVAG_120880   AGC family protein kinase
Trichomonas vaginalis TVAG_128470   CAMK family protein kinase
Trichomonas vaginalis TVAG_365470   CAMK family protein kinase
Trichomonas vaginalis TVAG_175420   AGC family protein kinase
Trichomonas vaginalis TVAG_274050   CAMK family protein kinase
Trichomonas vaginalis TVAG_134960   AGC family protein kinase
Trichomonas vaginalis TVAG_529020   CAMK family protein kinase
Trichomonas vaginalis TVAG_168610   CAMK family protein kinase
Trichomonas vaginalis TVAG_108980   CAMK family protein kinase
Trichomonas vaginalis TVAG_416500   CAMK family protein kinase
Trichomonas vaginalis TVAG_255770   AGC family protein kinase
Trichomonas vaginalis TVAG_104840   CAMK family protein kinase
Trichomonas vaginalis TVAG_049000   CAMK family protein kinase
Trichomonas vaginalis TVAG_029270   serine/threonine-protein kinase, putative
Trichomonas vaginalis TVAG_289480   CAMK family protein kinase
Trichomonas vaginalis TVAG_052670   CAMK family protein kinase
Trichomonas vaginalis TVAG_016910   AGC family protein kinase
Trichomonas vaginalis TVAG_043110   CAMK family protein kinase
Trichomonas vaginalis TVAG_165450   CAMK family protein kinase
Trichomonas vaginalis TVAG_464780   AGC family protein kinase
Trichomonas vaginalis TVAG_373800   CAMK family protein kinase
Trichomonas vaginalis TVAG_374010   CAMK family protein kinase
Trichomonas vaginalis TVAG_494920   CAMK family protein kinase
Trichomonas vaginalis TVAG_361510   CAMK family protein kinase
Trichomonas vaginalis TVAG_124820   CAMK family protein kinase
Trichomonas vaginalis TVAG_488910   CAMK family protein kinase
Trichomonas vaginalis TVAG_412970   CAMK family protein kinase
Trichomonas vaginalis TVAG_073330   CAMK family protein kinase
Trichomonas vaginalis TVAG_453190   STE family protein kinase
Trichomonas vaginalis TVAG_175460   calcium/calmodulin-dependent protein kinase II, putative
Trichomonas vaginalis TVAG_041470   mitogen activated protein kinase kinase, putative
Trichomonas vaginalis TVAG_417450   CAMK family protein kinase
Trichomonas vaginalis TVAG_116410   CAMK family protein kinase
Trichomonas vaginalis TVAG_292040   CAMK family protein kinase
Trichomonas vaginalis TVAG_374030   CAMK family protein kinase
Trichomonas vaginalis TVAG_403250   CAMK family protein kinase
Trichomonas vaginalis TVAG_112480   CAMK family protein kinase
Trichomonas vaginalis TVAG_042790   phophoinositide-dependent protein kinase, putative
Trichomonas vaginalis TVAG_306670   CAMK family protein kinase
Trichomonas vaginalis TVAG_455690   CAMK family protein kinase
Trichomonas vaginalis TVAG_475070   CAMK family protein kinase
Trichomonas vaginalis TVAG_274010   AGC family protein kinase
Trichomonas vaginalis TVAG_373790   CAMK family protein kinase
Trichomonas vaginalis TVAG_371770   CMGC family protein kinase
Trichomonas vaginalis TVAG_043140   CAMK family protein kinase
Trichomonas vaginalis TVAG_078600   CAMK family protein kinase
Trichomonas vaginalis TVAG_334320   CAMK family protein kinase
Trichomonas vaginalis TVAG_072550   AGC family protein kinase
Trichomonas vaginalis TVAG_280570   CAMK family protein kinase
Trichomonas vaginalis TVAG_048010   CAMK family protein kinase
Trichomonas vaginalis TVAG_242590   br serine/threonine-protein kinase, putative
Trichomonas vaginalis TVAG_155100   CAMK family protein kinase
Trichomonas vaginalis TVAG_382540   CAMK family protein kinase
Trichomonas vaginalis TVAG_384730   CAMK family protein kinase
Trichomonas vaginalis TVAG_030460   AGC family protein kinase
Trichomonas vaginalis TVAG_047950   CAMK family protein kinase
Trichomonas vaginalis TVAG_410040   CAMK family protein kinase
Trichomonas vaginalis TVAG_404300   serine/threonine protein kinase, putative
Trichomonas vaginalis TVAG_202230   CAMK family protein kinase
Trichomonas vaginalis TVAG_362580   CAMK family protein kinase
Trichomonas vaginalis TVAG_146740   cGMP-dependent protein kinase, putative
Trichomonas vaginalis TVAG_459460   CAMK family protein kinase
Trichomonas vaginalis TVAG_025050   CAMK family protein kinase
Trichomonas vaginalis TVAG_169960   AGC family protein kinase
Trichomonas vaginalis TVAG_095260   AGC family protein kinase
Trichomonas vaginalis TVAG_446480   AGC family protein kinase
Trichomonas vaginalis TVAG_116440   calcium/calmodulin-dependent protein kinase kinase, putative
Trichomonas vaginalis TVAG_277920   CAMK family protein kinase
Trichomonas vaginalis TVAG_184460   CAMK family protein kinase
Trichomonas vaginalis TVAG_073920   CAMK family protein kinase
Trichomonas vaginalis TVAG_175450   CAMK family protein kinase
Trichomonas vaginalis TVAG_464770   CAMK family protein kinase
Trichomonas vaginalis TVAG_156830   STE family protein kinase
Trichomonas vaginalis TVAG_136340   TKL family protein kinase
Trichomonas vaginalis TVAG_374060   mitogen activated protein kinase kinase kinase 6, MAPKKK6, MEKK6, putative
Trichomonas vaginalis TVAG_252190   CAMK family protein kinase
Trichomonas vaginalis TVAG_032080   AGC family protein kinase
Trichomonas vaginalis TVAG_000270   CAMK family protein kinase
Trichomonas vaginalis TVAG_462620   CAMK family protein kinase
Trichomonas vaginalis TVAG_007820   CAMK family protein kinase
Trichomonas vaginalis TVAG_270220   calcium-dependent protein kinase, putative
Trichomonas vaginalis TVAG_103470   CAMK family protein kinase
Trichomonas vaginalis TVAG_410110   CAMK family protein kinase
Trichomonas vaginalis TVAG_373860   CAMK family protein kinase
Trichomonas vaginalis TVAG_373780   cell cycle protein kinase dbf2, putative
Trichomonas vaginalis TVAG_531330   CAMK family protein kinase
Trichomonas vaginalis TVAG_373810   CAMK family protein kinase
Trichomonas vaginalis TVAG_460660   CAMK family protein kinase
Trichomonas vaginalis TVAG_082590   serine/threonine protein kinase, putative
Trichomonas vaginalis TVAG_072240   CAMK family protein kinase
Trichomonas vaginalis TVAG_373820   CAMK family protein kinase
Trichomonas vaginalis TVAG_340800   CAMK family protein kinase
Trichomonas vaginalis TVAG_488850   CAMK family protein kinase
Trichomonas vaginalis TVAG_311510   AGC family protein kinase
Trichomonas vaginalis TVAG_435820   CAMK family protein kinase
Trichomonas vaginalis TVAG_280460   CAMK family protein kinase
Trichomonas vaginalis TVAG_305000   STE family protein kinase
Trichomonas vaginalis TVAG_155090   CAMK family protein kinase
Trichomonas vaginalis TVAG_383540   AGC family protein kinase
Trichomonas vaginalis TVAG_347870   CAMK family protein kinase
Trichomonas vaginalis TVAG_156790   cAMP-dependent protein kinase sch9, putative
Trichomonas vaginalis TVAG_362320   CAMK family protein kinase
Trichomonas vaginalis TVAG_496960   CAMK family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2176 (Mycobacterium tuberculosis), Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L)
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