Detailed view for Rv2184c

Basic information

TDR Targets ID: 980277
Mycobacterium tuberculosis, Conserved hypothetical protein
Source Database / ID:  Tuberculist 

pI: 5.1481 | Length (AA): 379 | MW (Da): 40839 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02374  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016887   ATPase activity  
GO:0005524   ATP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 269 3h84 (A) 52 320 28.00 0.0000018 1 0.815563 0.77
128 255 4dhd (A) 11 130 39.00 0.44 0.1 0.229531 1.41
297 372 4fei (A) 49 138 32.00 0.12 0.98 0.451128 -0.56
302 378 1gme (A) 46 142 23.00 0.000042 0.99 0.268766 -0.3
319 373 3n3e (A) 80 147 22.00 0.58 0.81 0.173719 0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127181)

Species Accession Gene Product
Arabidopsis thaliana AT5G60730   Anion-transporting ATPase
Arabidopsis thaliana AT1G01910   putative anion-transporting ATPase
Arabidopsis thaliana AT3G10350   P-loop containing nucleoside triphosphate hydrolases superfamily protein
Babesia bovis BBOV_I001930   arsenical pump-driving ATPase, putative
Brugia malayi Bm1_42140   Putative arsenical pump-driving ATPase
Candida albicans CaO19.2965   similar to S. cerevisiae YDL100C
Candida albicans CaO19.10482   similar to S. cerevisiae YDL100C
Caenorhabditis elegans CELE_ZK637.5   Protein ASNA-1
Cryptosporidium hominis Chro.70452   arsenical pump-driving ATPase
Cryptosporidium parvum cgd7_4070   arsenical pump-driving ATPase
Dictyostelium discoideum DDB_G0293528   arsenite transport subunit A
Drosophila melanogaster Dmel_CG1598   CG1598 gene product from transcript CG1598-RA
Echinococcus granulosus EgrG_000247000   atpase asna1
Entamoeba histolytica EHI_177400   arsenite-translocating ATPase, putative
Echinococcus multilocularis EmuJ_000247000   atpase asna1
Giardia lamblia GL50803_7953   Arsenical pump-driving ATPase
Homo sapiens ENSG00000198356   arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Leishmania braziliensis LbrM.11.0490   anion-transporting ATPase-like protein
Leishmania donovani LdBPK_110710.1   anion-transporting ATPase-like protein
Leishmania infantum LinJ.11.0710   anion-transporting ATPase-like protein
Leishmania major LmjF.11.0700   anion-transporting ATPase-like protein
Leishmania mexicana LmxM.11.0700   anion-transporting ATPase-like protein
Loa Loa (eye worm) LOAG_01787   Asna1 protein
Mycobacterium leprae ML0890   CONSERVED HYPOTHETICAL PROTEIN
Mus musculus ENSMUSG00000052456   arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Mycobacterium tuberculosis Rv2184c   Conserved hypothetical protein
Mycobacterium ulcerans MUL_3539   hypothetical protein
Neospora caninum NCLIV_031560   Arsenite-activated ATPase ArsA (EC 3.6.3.16), related
Oryza sativa 4330712   Os02g0745000
Oryza sativa 4347615   Os09g0521500
Onchocerca volvulus OVOC10808b   ATPase ASNA1 homolog
Onchocerca volvulus OVOC10808a   ATPase ASNA1 homolog
Plasmodium berghei PBANKA_0717000   ATPase, putative
Plasmodium falciparum PF3D7_0415000   arsenical pump-driving ATPase, putative
Plasmodium knowlesi PKNH_0506600   arsenical pump-driving ATPase, putative
Plasmodium vivax PVX_089705   arsenical pump-driving ATPase, putative
Plasmodium yoelii PY02198   arsenite transport subunit A
Saccharomyces cerevisiae YDL100C   guanine nucleotide exchange factor GET3
Schistosoma japonicum Sjp_0218690   ko:K01551 arsenite-transporting ATPase [EC3.6.3.16], putative
Schistosoma mansoni Smp_092760   arsenical pump-driving atpase related
Schmidtea mediterranea mk4.001014.04   ATPase ASNA1
Schmidtea mediterranea mk4.001014.05  
Trypanosoma cruzi TcCLB.510101.490   anion-transporting ATPase-like, putative
Trypanosoma cruzi TcCLB.507763.30   anion-transporting ATPase-like, putative
Toxoplasma gondii TGME49_231190   arsenite-activated ATPase family protein
Theileria parva TP03_0142   arsenical pump-driving ATPase, putative
Trichomonas vaginalis TVAG_001690   arsenical pump-driving ATPase, putative
Trichomonas vaginalis TVAG_265910   arsenical pump driving ATPase, putative

Essentiality

Rv2184c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0717000 Plasmodium berghei Slow plasmo
TGME49_231190 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv2184c (Mycobacterium tuberculosis), Conserved hypothetical protein
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