Detailed view for Rv2187

Basic information

TDR Targets ID: 981037
Mycobacterium tuberculosis, Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Source Database / ID:  Tuberculist 

pI: 6.1564 | Length (AA): 600 | MW (Da): 64003 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Fatty acid biosynthesis (KEGG)
Fatty acid metabolism (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 595 3pbk (A) 14 567 19.00 0 1 1.06673 0.33
14 499 1ult (A) 16 471 21.00 0 1 1.0001 0.15
43 598 5msd (A) 85 635 26.00 0 1 1.09107 0.37
153 205 4gs5 (A) 6 58 19.00 0 0.08 0.320433 -0.55
347 464 4w8o (A) 292 426 37.00 0.0000033 0.69 0.362567 0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130027)

Species Accession Gene Product
Caenorhabditis elegans CELE_R07C3.4   Protein ACS-15
Caenorhabditis elegans CELE_R09E10.3   Protein ACS-18
Dictyostelium discoideum DDB_G0270106   hypothetical protein
Drosophila melanogaster Dmel_CG4501   bubblegum
Homo sapiens 23205   acyl-CoA synthetase bubblegum family member 1
Homo sapiens ENSG00000130377   acyl-CoA synthetase bubblegum family member 2
Mycobacterium leprae ML0887c   Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)
Mus musculus ENSMUSG00000032281   acyl-CoA synthetase bubblegum family member 1
Mus musculus ENSMUSG00000024207   acyl-CoA synthetase bubblegum family member 2
Mycobacterium tuberculosis Rv2187   Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium ulcerans MUL_3542   long-chain-fatty-acid-CoA ligase FadD15
Mycobacterium ulcerans MUL_4349   long-chain-fatty-acid-CoA ligase FadD15
Neospora caninum NCLIV_006300   very long-chain acyl-CoA synthetase, putative
Schmidtea mediterranea mk4.000084.06  
Schmidtea mediterranea mk4.000084.15  
Toxoplasma gondii TGME49_297220   AMP-binding enzyme domain-containing protein

Essentiality

Rv2187 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_297220 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Yersinia pestis AMP-binding enzyme family protein 525 aa 23.5% 451 aa Compounds References
Luciola lateralis Luciferase 548 aa 25.2% 492 aa Compounds References
Photuris pennsylvanica Luciferase 552 aa 23.6% 483 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2187 (Mycobacterium tuberculosis), Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
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