Detailed view for Rv2193

Basic information

TDR Targets ID: 981815
Mycobacterium tuberculosis, Probable cytochrome C oxidase (subunit III) CtaE
Source Database / ID:  Tuberculist 

pI: 9.5101 | Length (AA): 203 | MW (Da): 22388 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00510  

Gene Ontology

Mouse over links to read term descriptions.
GO:0019646   aerobic electron transport chain  
GO:0015002   heme-copper terminal oxidase activity  
GO:0016020   membrane  
GO:0004129   cytochrome-c oxidase activity  
GO:0022904   respiratory electron transport chain  

Metabolic Pathways

Oxidative phosphorylation (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 201 5b1a (C) 60 258 31.00 0 0.76 1.37782 -0.78
15 201 2yev (A) 607 790 27.00 0 0.81 1.32648 -0.76
19 202 1fft (C) 19 201 31.00 0 0.65 1.2387 0.31
28 200 1qle (C) 89 269 39.00 0 0.6 1.14682 -0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128583)

Species Accession Gene Product
Arabidopsis thaliana AT2G07687   cytochrome c oxidase subunit 3
Arabidopsis thaliana ArthMp065   cytochrome c oxidase subunit 3
Babesia bovis BBOV_VI000020   cytochrome c oxidase subunit III
Candida albicans CaalfMp04   cytochrome oxidase subunit 3
Candida albicans CaalfMp15   cytochrome oxidase subunit 3
Dictyostelium discoideum DidioMp04   cytochrome oxidase subunit 3
Escherichia coli b0430   cytochrome o ubiquinol oxidase subunit III
Echinococcus granulosus EgrG_900000000   Cytochrome c oxidase subunit III
Homo sapiens 4514   cytochrome c oxidase III
Mycobacterium leprae ML0882c   PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE
Mus musculus 17710   cytochrome c oxidase subunit III
Mycobacterium tuberculosis Rv2193   Probable cytochrome C oxidase (subunit III) CtaE
Mycobacterium ulcerans MUL_3550   cytochrome C oxidase (subunit III) CtaE
Oryza sativa 6450138   cytochrome c oxidase subunit 3
Onchocerca volvulus OVOC12995   Cytochrome c oxidase subunit 3
Plasmodium berghei PBANKA_MIT01100   cytochrome c oxidase subunit 3
Plasmodium knowlesi PKNH_MIT01100   cytochrome c oxidase subunit 3
Plasmodium vivax PVX_244295   unspecified product
Plasmodium vivax PVAD80_MIT0001   cytochrome c oxidase subunit 3
Plasmodium yoelii PY00770   Cytochrome c oxidase subunit III
Plasmodium yoelii PY00776   Cytochrome c oxidase subunit III
Plasmodium yoelii PY00144   Cytochrome c oxidase subunit III
Saccharomyces cerevisiae Q0275   cytochrome c oxidase subunit 3
Schistosoma japonicum Sjp_0317030   IPR000298,Cytochrome c oxidase, subunit III,domain-containing
Schistosoma mansoni Smp_181810   cytochrome-c oxidase
Toxoplasma gondii TGME49_237120   hypothetical protein
Toxoplasma gondii TGME49_322600   hypothetical protein
Toxoplasma gondii TGME49_323400   cytochrome c oxidase subunit iii subfamily protein
Theileria parva Tpmp2   cytochrome oxidase subunit III
Wolbachia endosymbiont of Brugia malayi Wbm0698   cytochrome c oxidase, subunit 3

Essentiality

Rv2193 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0430 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE (SUBUNIT III) CTAE Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2193 (Mycobacterium tuberculosis), Probable cytochrome C oxidase (subunit III) CtaE
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