pI: 4.1856 |
Length (AA): 118 |
MW (Da): 12544 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 118 | 2d2a (A) | 9 | 121 | 32.00 | 0 | 1 | 1.3953 | -0.46 |
12 | 109 | 1r94 (A) | 1 | 97 | 33.00 | 0.00000000002 | 1 | 1.29951 | -0.59 |
13 | 118 | 2apn (A) | 8 | 113 | 44.00 | 0 | 1 | 1.44331 | -0.15 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Dormant phase, Dormant phase. | hasan murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_127463)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G03905 | Iron-sulfur assembly protein IscA-like 2 |
Babesia bovis | BBOV_III007130 | HesB-like domain containing protein |
Babesia bovis | BBOV_III006900 | HesB-like domain containing protein |
Brugia malayi | Bm1_18330 | Iron-sulfur cluster assembly accessory protein |
Brugia malayi | Bm1_04165 | Iron-sulfur cluster assembly accessory protein |
Candida albicans | CaO19.14103 | similar to Iron Sulfur cluster Assembly protein |
Candida albicans | CaO19.6811 | similar to Iron Sulfur cluster Assembly protein |
Caenorhabditis elegans | CELE_Y54G11A.9 | Protein Y54G11A.9 |
Dictyostelium discoideum | DDB_G0284809 | HesB/YadR/YfhF domain-containing protein |
Drosophila melanogaster | Dmel_CG13623 | CG13623 gene product from transcript CG13623-RA |
Escherichia coli | b0156 | iron-sulfur cluster insertion protein |
Echinococcus granulosus | EgrG_000211050 | iron sulfur cluster assembly 2 |
Echinococcus multilocularis | EmuJ_000211050 | iron sulfur cluster assembly 2 |
Giardia lamblia | GL50803_14821 | HesB domain-containing protein |
Homo sapiens | 122961 | iron-sulfur cluster assembly 2 |
Leishmania braziliensis | LbrM.34.1260 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_351350.1 | Iron-sulfur assembly protein 2, putative |
Leishmania infantum | LinJ.35.1350 | hypothetical protein, conserved |
Leishmania major | LmjF.35.1350 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.34.1350 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_08328 | iron-sulfur cluster assembly accessory protein |
Mycobacterium leprae | ML0871 | conserved hypothetical protein |
Mus musculus | ENSMUSG00000021241 | iron-sulfur cluster assembly 2 homolog (S. cerevisiae) |
Mycobacterium tuberculosis | Rv2204c | Conserved protein |
Mycobacterium ulcerans | MUL_3561 | hypothetical protein |
Oryza sativa | 4340113 | Os06g0146400 |
Oryza sativa | 9271865 | Os08g0363800 |
Oryza sativa | 4345405 | Os08g0369700 |
Plasmodium berghei | PBANKA_0304600 | iron-sulfur assembly protein, putative |
Plasmodium berghei | PBANKA_1237400 | iron-sulfur assembly protein |
Plasmodium falciparum | PF3D7_0207200 | iron-sulfur assembly protein, putative |
Plasmodium falciparum | PF3D7_0522700 | iron-sulfur assembly protein, putative |
Plasmodium knowlesi | PKNH_0413900 | iron-sulfur assembly protein, putative |
Plasmodium vivax | PVX_003785 | iron-sulfur cluster assembly accessory protein, putative |
Plasmodium yoelii | PY02064 | member hesB family |
Plasmodium yoelii | PY00043 | HesB-like domain, putative |
Saccharomyces cerevisiae | YPR067W | Isa2p |
Schistosoma japonicum | Sjp_0059250 | Iron-sulfur cluster assembly 2 homolog, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_034530.2 | hes-B related |
Schmidtea mediterranea | mk4.001801.03 | Iron-sulfur cluster assembly 2 homolog, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.5.1400 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.5.1030 | Iron-sulfur assembly protein 2 |
Trypanosoma congolense | TcIL3000_5_780 | Iron-sulfur assembly protein 2, putative |
Trypanosoma cruzi | TcCLB.511181.30 | Iron-sulfur assembly protein 2, putative |
Trypanosoma cruzi | TcCLB.503465.30 | Iron-sulfur assembly protein 2, putative |
Theileria parva | TP04_0596 | hypothetical protein |
Theileria parva | TP04_0597 | hypothetical protein |
Trichomonas vaginalis | TVAG_456770 | iron-sulfur cluster assembly protein, putative |
Trichomonas vaginalis | TVAG_055320 | iron sulfur assembly protein, putative |
Trichomonas vaginalis | TVAG_361540 | iron-sulfur assembly protein, putative |
Trichomonas vaginalis | TVAG_373690 | conserved hypothetical protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0024 | HesB/YadR/YfhF family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2238 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.5.1030 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.1030 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.1030 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.1030 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0156 | Escherichia coli | essential | goodall |
PBANKA_0304600 | Plasmodium berghei | Essential | plasmo |
PBANKA_1237400 | Plasmodium berghei | Dispensable | plasmo |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.