pI: 7.3861 |
Length (AA): 301 |
MW (Da): 31672 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 298 | 3oh8 (A) | 146 | 441 | 39.00 | 0 | 1 | 1.33391 | -0.13 |
4 | 296 | 4b4o (A) | 1 | 291 | 33.00 | 0 | 1 | 1.39962 | -0.62 |
4 | 69 | 2dkn (A) | 2 | 60 | 44.00 | 0.97 | 0.34 | 0.523969 | 0.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase, Dormant phase. | hasan murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_130575)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G21280 | plastid-targeted protein SulA |
Dictyostelium discoideum | DDB_G0279965 | DUF1731 family protein |
Drosophila melanogaster | Dmel_CG8768 | CG8768 gene product from transcript CG8768-RA |
Escherichia coli | b2304 | putative NAD-dependent nucleotide-sugar epimerase |
Echinococcus granulosus | EgrG_000708500 | epimerase family protein sdr39u1 |
Echinococcus multilocularis | EmuJ_000708500 | epimerase family protein sdr39u1 |
Homo sapiens | ENSG00000100445 | short chain dehydrogenase/reductase family 39U, member 1 |
Mycobacterium leprae | ML0860c | conserved hypothetical protein |
Mus musculus | ENSMUSG00000022223 | short chain dehydrogenase/reductase family 39U, member 1 |
Mycobacterium tuberculosis | Rv2216 | Conserved protein |
Mycobacterium ulcerans | MUL_1355 | hypothetical protein |
Mycobacterium ulcerans | MUL_3576 | hypothetical protein |
Neospora caninum | NCLIV_063100 | hypothetical protein, conserved |
Oryza sativa | 4331275 | Os02g0834700 |
Schistosoma japonicum | Sjp_0028500 | ko:K07071 cell division inhibitor,NAD dependent epimerase/dehydratase family, putative |
Schistosoma mansoni | Smp_025150 | sugar nucleotide epimerase related |
Schmidtea mediterranea | mk4.004880.00 | Epimerase family protein SDR39U1 |
Toxoplasma gondii | TGME49_246080 | NAD dependent epimerase/dehydratase family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2250 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
b2304 | Escherichia coli | non-essential | goodall |
TGME49_246080 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.