Detailed view for Rv2392

Basic information

TDR Targets ID: 5838
Mycobacterium tuberculosis, PROBABLE 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE REDUCTASE CYSH (PAPS REDUCTASE, THIOREDOXIN DEP.) (PADOPS REDUCTASE) (3'- PHOSPHO

Source Database / ID: Tuberculist / Rv2392 

pI: 5 | Length (AA): 254 | MW (Da): 27423 | Number of Paralogs: 0

EC number(s): 1.8.4.8 | Enzyme, KEGG, Brenda (mouse over to display more information)
1.8.99.4 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF01507   PAPS_reduct

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0016740   transferase activity  

Process: (mouse over links to read term descriptions)

GO:0008152   metabolic process  
GO:0019344   cysteine biosynthetic process  
Metabolic Pathways

Sulfur metabolism (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 10
Cumulative epitope score: 11.5
Normalized epitope score: 4.5
Percentile: 38.7 (this protein belongs to the top 61.3% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_13376
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_192370   APR1 (APS REDUCTASE 1); adenylyl-sulfate reductase ... |   OrthoMCL
Arabidopsis thaliana NP_193930   APR3 (APS REDUCTASE 3); adenylyl-sulfate reductase ... |   OrthoMCL
Arabidopsis thaliana NP_176409   APR2 (5ADENYLYLPHOSPHOSULFATE REDUCTASE 2); adenylyl-sulfat... |   OrthoMCL
Cryptosporidium neoformas XP_569215   phosphoadenylyl-sulfate reductase (thioredoxin) ... |   OrthoMCL
Escherichia coli K12 NP_417242.1   phosphoadenosine phosphosulfate reductase [Escherichia coli ... |   OrthoMCL
Mycobacterium tuberculosis Rv2392 (this record).   PROBABLE 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE REDUCTASE CYS... |   OrthoMCL
Oryza sativa NP_001059750   Os07g0509800 ... |   OrthoMCL
Saccharomyces cerevisiae YPR167C   MET16 SGDID:S000006371, Chr XVI from 877628-876843, reverse ... |   OrthoMCL

Essentiality Rv2392 has essentiality data
Gene/Ortholog: mtu2433 (OG4_13376); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: eco2670 (OG4_13376); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco2670 (OG4_13376); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco2670 (OG4_13376); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco2670 (OG4_13376); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: auxotroph (PATO:0000422) [+/–] show term definition
Evidence: inferred from loss-of-function mutant phenotype (ECO:0000016)
Observed in: Mycobacterium smegmatis (NEWT:1772)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-31.
PubMed References: 12072441 16553880

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition
Evidence: inferred from animal model system (ECO:0000179)
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-31.
PubMed References: 16553880

No validation aspects annotated for this target.

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    Assay: Assayed; Source: BRENDA
    Description: An enzyme with this EC number or name or sequence has been assayed in Mycobacterium tuberculosis ( 1 2 );

    Reagent availability

    Reagent: Rv2392; Type: cloned gene; Source: BRENDA
    Notes: A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 2 3 4 ); Mycobacterium smegmatis ( 1 );

    Bibliographic references

    2 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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