Detailed view for Rv2396

Basic information

TDR Targets ID: 6696
Mycobacterium tuberculosis, PE-PGRS FAMILY PROTEIN

Source Database / ID: Tuberculist / Rv2396 

pI: 3.85 | Length (AA): 361 | MW (Da): 30724 | Number of Paralogs: 52

EC number(s): No EC number(s) registered for this gene.

Signal peptide: Y | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00934   PE

Gene Ontology No GO information for this protein.
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 80-100% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 10
Cumulative epitope score: 10.9
Normalized epitope score: 3.0
Percentile: 4.2 (this protein belongs to the top 95.8% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_13054
Number of Paralogs: 52

Ortholog group members from selected species:
Mycobacterium leprae strain TN ML0946   conserved hypothetical protein... |   OrthoMCL
Mycobacterium tuberculosis Rv0109   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0747   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0754   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0833   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0834c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0872c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0977   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0978c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0980c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1067c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0124   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1068c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1087   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1091   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1243c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1325c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1396c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1441c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1450c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1452c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1468c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0278c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1651c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1768   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1803c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1818c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1840c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1983   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2162c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2340c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0279c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2396 (this record).   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2487c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2490c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2591   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2615c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2634c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2741   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv2853   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv1759c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0297   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3345c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3367   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3388   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3507   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3508   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3511   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3514   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3590c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3595c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0532   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3653   PE-PGRS FAMILY-RELATED PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0578c   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv0746   PE-PGRS FAMILY PROTEIN... |   OrthoMCL
Mycobacterium tuberculosis Rv3390   PROBABLE CONSERVED LIPOPROTEIN LPQD... |   OrthoMCL

Essentiality Rv2396 has essentiality data
Gene/Ortholog: mtu3450 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu760 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu768 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu888 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu992 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1084 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1264 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1348 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1419 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1464 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1491 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1680 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1848 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1870 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2196 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2381 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2437 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2635 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2661 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2680 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu2900 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu300 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu3427 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu3568 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu3652 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu3657 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu586 (OG4_13054); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1789 (OG4_13054); Phenotype: non-essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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