Detailed view for Rv2397c

Basic information

TDR Targets ID: 5832
Mycobacterium tuberculosis, PROBABLE SULFATE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER CYSA1

Source Database / ID: Tuberculist / Rv2397c 

pI: 9.59 | Length (AA): 351 | MW (Da): 37444 | Number of Paralogs: 0

EC number(s): 3.6.3.25 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00005   ABC_tran
PF03459   TOBE

Gene Ontology

Component: (mouse over links to read term descriptions)

GO:0016020   membrane  

Function: (mouse over links to read term descriptions)

GO:0005215   transporter activity  
GO:0000166   nucleotide binding  
GO:0017111   nucleoside-triphosphatase activity  
GO:0016887   ATPase activity  
GO:0005524   ATP binding  

Process: (mouse over links to read term descriptions)

GO:0006810   transport  
Metabolic Pathways

ABC transporters (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 16
Cumulative epitope score: 18.0
Normalized epitope score: 5.1
Percentile: 68.5 (this protein belongs to the top 31.5% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10981
Number of Paralogs: 0

Ortholog group members from selected species:
Escherichia coli K12 NP_416917.1   sulfate/thiosulfate transporter subunit [Escherichia coli K1... |   OrthoMCL
Escherichia coli K12 NP_415376.4   putrescine transporter subunit: ATP-binding component of ABC... |   OrthoMCL
Escherichia coli K12 NP_415644.1   putrescine/spermidine ABC transporter ATPase protein [Escher... |   OrthoMCL
Escherichia coli K12 NP_415958.1   predicted spermidine/putrescine transporter subunit [Escheri... |   OrthoMCL
Escherichia coli K12 NP_414796.2   CP4-6 prophage; predicted ferric transporter subunit [Escher... |   OrthoMCL
Mycobacterium tuberculosis Rv2397c (this record).   PROBABLE SULFATE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORT... |   OrthoMCL

Essentiality Rv2397c has essentiality data
Gene/Ortholog: mtu2438 (OG4_10981); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: eco1090 (OG4_10981); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco1090 (OG4_10981); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco1090 (OG4_10981); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco1090 (OG4_10981); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco1401 (OG4_10981); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco1401 (OG4_10981); Phenotype: essential; Source study: gerdes
Gene/Ortholog: eco1401 (OG4_10981); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco1401 (OG4_10981); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco2343 (OG4_10981); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco2343 (OG4_10981); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco2343 (OG4_10981); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco2343 (OG4_10981); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

    Log in to add comments, or register.