Detailed view for Rv2399c

Basic information

TDR Targets ID: 5845
Mycobacterium tuberculosis, PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYST

Source Database / ID: Tuberculist / Rv2399c 

pI: 10 | Length (AA): 283 | MW (Da): 29683 | Number of Paralogs: 1

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 6

Pfam domains

PF00528   BPD_transp_1

Gene Ontology

Component: (mouse over links to read term descriptions)

GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0009276   Gram-negative-bacterium-type cell wall  

Function: (mouse over links to read term descriptions)

GO:0005215   transporter activity  
GO:0015563   uptake transmembrane transporter activity  
GO:0015116   sulfate transmembrane transporter activity  

Process: (mouse over links to read term descriptions)

GO:0006810   transport  
GO:0008272   sulfate transport  
Metabolic Pathways

ABC transporters (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 80-100% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 9
Cumulative epitope score: 10.6
Normalized epitope score: 3.8
Percentile: 13.7 (this protein belongs to the top 86.3% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_12993
Number of Paralogs: 1

Ortholog group members from selected species:
Escherichia coli K12 NP_416919.1   sulfate/thiosulfate transporter subunit [Escherichia coli K1... |   OrthoMCL
Escherichia coli K12 NP_415285.1   molybdate ABC transporter permease protein [Escherichia coli... |   OrthoMCL
Mycobacterium tuberculosis Rv1858   PROBABLE MOLBDENUM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC T... |   OrthoMCL
Mycobacterium tuberculosis Rv2399c (this record).   PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRA... |   OrthoMCL

Essentiality Rv2399c has essentiality data
Gene/Ortholog: mtu2440 (OG4_12993); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: mtu1888 (OG4_12993); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco735 (OG4_12993); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco735 (OG4_12993); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco735 (OG4_12993); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco735 (OG4_12993); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco2345 (OG4_12993); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco2345 (OG4_12993); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco2345 (OG4_12993); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco2345 (OG4_12993); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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