pI: 6.4355 |
Length (AA): 479 |
MW (Da): 50429 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 344 | 5m04 (A) | 1 | 337 | 38.00 | 0 | 1 | 1.13618 | 0.11 |
4 | 437 | 1udx (A) | 2 | 415 | 46.00 | 0 | 1 | 1.38525 | 0.13 |
143 | 269 | 4a9a (A) | 42 | 169 | 34.00 | 0 | 0.92 | 0.608136 | -0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127170)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G07615 | GTP-binding protein Obg/CgtA |
Arabidopsis thaliana | AT5G18570 | OBGC-like protein |
Babesia bovis | BBOV_III000430 | hypothetical protein |
Babesia bovis | BBOV_IV004510 | GTPase family protein |
Brugia malayi | Bm1_49205 | GTP1/OBG family protein |
Candida albicans | CaO19.13974 | similar to S. cerevisiae YHR168W |
Candida albicans | CaO19.6653 | similar to S. cerevisiae YHR168W |
Caenorhabditis elegans | CELE_M01E5.2 | Protein M01E5.2 |
Chlamydia trachomatis | CT_418 | GTPase Obg |
Dictyostelium discoideum | DDB_G0277801 | GTP-binding protein 5 |
Drosophila melanogaster | Dmel_CG13390 | CG13390 gene product from transcript CG13390-RA |
Escherichia coli | b3183 | GTPase involved in cell partioning and DNA repair |
Echinococcus granulosus | EgrG_000665900 | GTP binding protein 5 |
Echinococcus multilocularis | EmuJ_000665900 | GTP binding protein 5 |
Homo sapiens | ENSG00000101181 | mitochondrial ribosome-associated GTPase 2 |
Leishmania braziliensis | LbrM.35.3210 | GTP-binding protein, putative |
Leishmania donovani | LdBPK_363140.1 | GTP-binding protein, putative |
Leishmania infantum | LinJ.36.3140 | GTP-binding protein, putative |
Leishmania major | LmjF.36.2990 | GTP-binding protein, putative |
Leishmania mexicana | LmxM.36.2990 | GTP-binding protein, putative |
Loa Loa (eye worm) | LOAG_01749 | GTP1/OBG family protein |
Mycobacterium leprae | ML1465c | PROBABLE GTP1/OBG-FAMILY GTP-BINDING PROTEIN OBG |
Mus musculus | ENSMUSG00000039069 | mitochondrial ribosome associated GTPase 2 |
Mycobacterium tuberculosis | Rv2440c | Probable GTP1/Obg-family GTP-binding protein Obg |
Mycobacterium ulcerans | MUL_3712 | GTPase ObgE |
Neospora caninum | NCLIV_058650 | hypothetical protein |
Oryza sativa | 4351211 | Os11g0704300 |
Oryza sativa | 4344232 | Os07g0669200 |
Onchocerca volvulus | OVOC13428 |
|
Plasmodium berghei | PBANKA_1030900 | GTP-binding protein, putative |
Plasmodium falciparum | PF3D7_1411600 | GTP-binding protein, putative |
Plasmodium knowlesi | PKNH_1346700 | GTP-binding protein, putative |
Plasmodium vivax | PVX_085875 | GTP-binding protein, putative |
Plasmodium yoelii | PY00161 | GTP-binding protein-related |
Saccharomyces cerevisiae | YHR168W | putative GTPase MTG2 |
Schistosoma mansoni | Smp_191360 | mitochondrial gtpase |
Schmidtea mediterranea | mk4.004678.01 | Mitochondrial ribosome-associated GTPase 2 |
Trypanosoma brucei gambiense | Tbg972.10.9110 | GTP-binding protein, putative |
Trypanosoma brucei | Tb927.10.7430 | GTP-binding protein, putative |
Trypanosoma congolense | TcIL3000_10_6400 | GTP-binding protein, putative |
Trypanosoma cruzi | TcCLB.507769.40 | GTP-binding protein, putative |
Trypanosoma cruzi | TcCLB.506553.30 | GTP-binding protein, putative |
Toxoplasma gondii | TGME49_316120 | hypothetical protein |
Treponema pallidum | TP0742 | GTPase ObgE |
Theileria parva | TP01_0299 | hypothetical protein |
Theileria parva | TP03_0795 | hypothetical protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0120 | GTPase ObgE |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.7430 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.7430 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.7430 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.7430 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3183 | Escherichia coli | essential | goodall |
TGME49_316120 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.