pI: 12.066 |
Length (AA): 86 |
MW (Da): 8968 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 83 | 5dm6 (T) | 2 | 84 | 60.00 | 0 | 1 | 1.62339 | -0.19 |
20 | 82 | 1v8q (A) | 20 | 83 | 65.00 | 0.000000000013 | 1 | 1.49346 | -0.9 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase, Dormant phase. | hasan murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127361)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G16930 | ribosomal protein L27 family protein |
Arabidopsis thaliana | AT5G15220 | large subunit ribosomal protein L27 |
Arabidopsis thaliana | AT5G40950 | 50S ribosomal protein L27 |
Babesia bovis | BBOV_IV007200 | ribosomal protein L27, putative |
Candida albicans | CaO19_7203 | hypothetical protein |
Candida albicans | CaO19.7203 | likely mitochondrial ribosomal protein similar to S. cerevisiae MRP7 (YNL005C) large subunit protein (E. coli L27) |
Chlamydia trachomatis | CT_419 | 50S ribosomal protein L27 |
Dictyostelium discoideum | DDB_G0278889 | ribosomal protein L27, mitochondrial |
Drosophila melanogaster | Dmel_CG33002 | mitochondrial ribosomal protein L27 |
Escherichia coli | b3185 | 50S ribosomal subunit protein L27 |
Echinococcus granulosus | EgrG_000696000 | Mitochondrial 39S ribosomal protein L27 L27mt |
Echinococcus multilocularis | EmuJ_000696000 | Mitochondrial 39S ribosomal protein L27 (L27mt) |
Homo sapiens | ENSG00000108826 | mitochondrial ribosomal protein L27 |
Mycobacterium leprae | ML1466c | PROBABLE 50S RIBOSOMAL PROTEIN L27 RPMA |
Mus musculus | ENSMUSG00000024414 | mitochondrial ribosomal protein L27 |
Mycobacterium tuberculosis | Rv2441c | 50S ribosomal protein L27 RpmA |
Mycobacterium ulcerans | MUL_3713 | 50S ribosomal protein L27 |
Neospora caninum | NCLIV_000540 | 50S ribosomal protein L27, chloroplastic, related |
Oryza sativa | 9271228 | Os08g0404250 |
Oryza sativa | 4327257 | Os01g0924000 |
Oryza sativa | 4345523 | Os08g0404300 |
Plasmodium berghei | PBANKA_0518000 | apicoplast ribosomal protein L27 precursor, putative |
Plasmodium falciparum | PF3D7_1034200 | apicoplast ribosomal protein L27 precursor, putative |
Plasmodium knowlesi | PKNH_0619400 | apicoplast ribosomal protein L27 precursor, putative |
Plasmodium vivax | PVX_111015 | 50S ribosomal protein L27, putative |
Plasmodium yoelii | PY00465 | ribosomal protein L27, putative |
Saccharomyces cerevisiae | YNL005C | mitochondrial 54S ribosomal protein YmL2 |
Schistosoma japonicum | Sjp_0313340 | expressed protein |
Schistosoma mansoni | Smp_037120 | Mitochondrial 39S ribosomal protein L27 (L27mt) (MRP-L27) |
Schmidtea mediterranea | mk4.045079.04 | |
Schmidtea mediterranea | mk4.073758.00 | |
Schmidtea mediterranea | mk4.000818.07 | Putative mitochondrial 39S ribosomal protein L27 |
Toxoplasma gondii | TGME49_293600 | ribosomal protein RPL27 |
Treponema pallidum | TP0743 | 50S ribosomal protein L27 |
Theileria parva | TP03_0228 | 60S ribosomal protein L27, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0700 | 50S ribosomal protein L27 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2484 this record | Mycobacterium tuberculosis | essential | nmpdr |
b3185 | Escherichia coli | essential | goodall |
TGME49_293600 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.