pI: 4.7843 |
Length (AA): 426 |
MW (Da): 46783 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
8 | 50 | 2ds5 (A) | 9 | 51 | 77.00 | 0 | 1 | 0.938139 | 0.27 |
58 | 412 | 1um8 (A) | 76 | 437 | 52.00 | 0 | 1 | 1.35853 | -0.61 |
61 | 412 | 3hws (A) | 64 | 412 | 63.00 | 0 | 1 | 1.51349 | -0.63 |
61 | 412 | 4i81 (C) | 64 | 412 | 56.00 | 0 | 1 | 1.19679 | 0.11 |
320 | 405 | 1qzm (A) | 496 | 577 | 18.00 | 0 | 1 | 0.549378 | -1.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_128011)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G53350 | CLP protease regulatory subunit X |
Arabidopsis thaliana | AT5G49840 | ATP-dependent Clp protease |
Arabidopsis thaliana | AT1G33360 | ATP-dependent Clp protease |
Brugia malayi | Bm1_57610 | ATP-dependent Clp protease, ATP-binding subunit, putative |
Caenorhabditis elegans | CELE_D2030.2 | Protein D2030.2, isoform B |
Chlamydia trachomatis | CT_705 | ATP-dependent Clp protease ATP-binding subunit ClpX |
Drosophila melanogaster | Dmel_CG4538 | CG4538 gene product from transcript CG4538-RC |
Escherichia coli | b0438 | ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease |
Echinococcus granulosus | EgrG_001010800 | ATP dependent Clp Protease ATP binding subunit |
Echinococcus multilocularis | EmuJ_001010800 | ATP dependent Clp Protease ATP binding subunit |
Homo sapiens | 10845 | caseinolytic mitochondrial matrix peptidase chaperone subunit |
Loa Loa (eye worm) | LOAG_03700 | ATP-dependent Clp protease |
Mycobacterium leprae | ML1477c | PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX |
Mus musculus | ENSMUSG00000015357 | caseinolytic mitochondrial matrix peptidase chaperone subunit |
Mycobacterium tuberculosis | Rv2457c | Probable ATP-dependent CLP protease ATP-binding subunit ClpX |
Mycobacterium ulcerans | MUL_3728 | ATP-dependent protease ATP-binding subunit ClpX |
Neospora caninum | NCLIV_012090 | ATP-dependent protease ATP-binding subunit, putative |
Oryza sativa | 4324891 | Os01g0886600 |
Oryza sativa | 4329696 | Os02g0564400 |
Saccharomyces cerevisiae | YBR227C | Mcx1p |
Schistosoma japonicum | Sjp_0057960 | ko:K03544 ATP-dependent Clp protease ATP-binding subunit ClpX, putative |
Schistosoma japonicum | Sjp_0057950 | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_063480 | ATP-dependent clp protease ATP-binding subunit clpx |
Schmidtea mediterranea | mk4.000896.04 | |
Schmidtea mediterranea | mk4.028359.00 | Putative hsl and clp protease |
Schmidtea mediterranea | mk4.013929.01 | |
Schmidtea mediterranea | mk4.008842.01 | |
Schmidtea mediterranea | mk4.019730.00 | Putative hsl and clp protease |
Schmidtea mediterranea | mk4.042617.00 | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial |
Schmidtea mediterranea | mk4.008842.03 | |
Treponema pallidum | TP0508 | ATP-dependent protease ATP-binding subunit ClpX |
Wolbachia endosymbiont of Brugia malayi | Wbm0552 | ATP-dependent protease ATP-binding subunit ClpX |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2500 this record | Mycobacterium tuberculosis | essential | nmpdr |
b0438 | Escherichia coli | non-essential | goodall |
CELE_D2030.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_D2030.2 | Caenorhabditis elegans | slow growth | wormbase |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2