Detailed view for Rv2465c

Basic information

TDR Targets ID: 981287
Mycobacterium tuberculosis, Ribose-5-phosphate isomerase
Source Database / ID:  Tuberculist 

pI: 6.5988 | Length (AA): 162 | MW (Da): 17278 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 159 2vvp (A) 3 159 99.99 0 1 2.19384 -1.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129695)

Species Accession Gene Product
Arabidopsis thaliana AT3G04880   DNA-damage-repair/toleration protein DRT102
Escherichia coli b4090   ribose 5-phosphate isomerase B/allose 6-phosphate isomerase
Entamoeba histolytica EHI_176150   ribose 5-phosphate isomerase, putative
Giardia lamblia GL50803_27614   Ribose 5-phosphate isomerase
Leishmania braziliensis LbrM.28.2170   ribose 5-phosphate isomerase, putative
Leishmania donovani LdBPK_282100.1   ribose 5-phosphate isomerase, putative
Leishmania infantum LinJ.28.2100   ribose 5-phosphate isomerase, putative
Leishmania major LmjF.28.1970   ribose 5-phosphate isomerase, putative
Leishmania mexicana LmxM.28.1970   ribose 5-phosphate isomerase, putative
Mycobacterium leprae ML1484c   PROBABLE ISOMERASE
Mycobacterium tuberculosis Rv2465c   Ribose-5-phosphate isomerase
Mycobacterium ulcerans MUL_3738   ribose-5-phosphate isomerase B
Oryza sativa 4326870   Os01g0542000
Trypanosoma brucei gambiense Tbg972.11.10030   ribose 5-phosphate isomerase, putative
Trypanosoma brucei Tb927.11.8970   ribose 5-phosphate isomerase, putative
Trypanosoma congolense TcIL3000_0_48580   ribose 5-phosphate isomerase, putative
Trypanosoma congolense TcIL3000.11.9280   ribose 5-phosphate isomerase, putative
Trypanosoma cruzi TcCLB.509199.24   ribose 5-phosphate isomerase type B
Trypanosoma cruzi TcCLB.508601.119   ribose 5-phosphate isomerase, putative
Trichomonas vaginalis TVAG_312320   conserved hypothetical protein
Trichomonas vaginalis TVAG_248050   conserved hypothetical protein

Essentiality

Rv2465c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0700 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.0700 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.0700 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0700 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b4090 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis rpiB

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2465c (Mycobacterium tuberculosis), Ribose-5-phosphate isomerase
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