Detailed view for Rv2467

Basic information

TDR Targets ID: 980796
Mycobacterium tuberculosis, Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase)
Source Database / ID:  Tuberculist 

pI: 4.6836 | Length (AA): 861 | MW (Da): 94253 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Glutathione metabolism (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 860 4fyt (A) 65 956 16.00 0.000062 1 1.12195 0.61
15 860 2yd0 (A) 55 927 20.00 0.00000082 1 1.18718 0.23
22 458 4jbs (A) 77 555 22.00 0 1 0.756349 -0.16
128 432 4wz9 (A) 196 499 34.00 0 1 0.671039 0.02
274 352 2iuf (A) 39 108 40.00 0.67 0.04 0.135554 2.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127177)

Species Accession Gene Product
Arabidopsis thaliana AT4G33090   aminopeptidase M1
Brugia malayi Bm1_27885   Peptidase family M1 containing protein
Candida albicans CaO19.5197   alanine/arginine aminopeptidase
Candida albicans CaO19.12664   alanine/arginine aminopeptidase
Caenorhabditis elegans CELE_T16G12.1   Protein T16G12.1
Caenorhabditis elegans CELE_F49E8.3   Protein PAM-1, isoform A
Dictyostelium discoideum DDB_G0270994   puromycin-sensitive aminopeptidase-like protein
Dictyostelium discoideum DDB_G0270670   puromycin-sensitive aminopeptidase-like protein
Drosophila melanogaster Dmel_CG1009   Puromycin sensitive aminopeptidase
Echinococcus granulosus EgrG_001105200   puromycin sensitive aminopeptidase
Echinococcus granulosus EgrG_002027100   puromycin sensitive aminopeptidase
Echinococcus granulosus EgrG_000350500   puromycin sensitive aminopeptidase
Echinococcus granulosus EgrG_000356700   puromycin sensitive aminopeptidase
Echinococcus granulosus EgrG_000350300   puromycin sensitive aminopeptidase
Echinococcus granulosus EgrG_000350600   puromycin sensitive aminopeptidase
Entamoeba histolytica EHI_008380   aminopeptidase, putative
Echinococcus multilocularis EmuJ_000350500   puromycin sensitive aminopeptidase
Echinococcus multilocularis EmuJ_000350600   puromycin sensitive aminopeptidase
Echinococcus multilocularis EmuJ_001105000   Peptidase M1, membrane alanine aminopeptidase, N terminal
Echinococcus multilocularis EmuJ_000350300   puromycin sensitive aminopeptidase
Echinococcus multilocularis EmuJ_001105200   puromycin sensitive aminopeptidase
Echinococcus multilocularis EmuJ_000356700   puromycin sensitive aminopeptidase
Echinococcus multilocularis EmuJ_000275200   puromycin sensitive aminopeptidase
Homo sapiens ENSG00000141279   aminopeptidase puromycin sensitive
Homo sapiens 101929950   puromycin-sensitive aminopeptidase-like protein-like
Homo sapiens 101060212   puromycin-sensitive aminopeptidase-like protein-like
Leishmania braziliensis LbrM.26.0330   aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1
Leishmania donovani LdBPK_260290.1   aminopeptidase-like protein
Leishmania infantum LinJ.26.0290   aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1
Leishmania major LmjF.26.0300   aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1
Leishmania mexicana LmxM.26.0300   aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1
Loa Loa (eye worm) LOAG_08229   aminopeptidase N
Loa Loa (eye worm) LOAG_15383   hypothetical protein
Mycobacterium leprae ML1486   PROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE)
Mus musculus ENSMUSG00000001441   aminopeptidase puromycin sensitive
Mycobacterium tuberculosis Rv2467   Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase)
Mycobacterium ulcerans MUL_4357   aminopeptidase N PepN
Mycobacterium ulcerans MUL_3742   aminopeptidase N PepN
Oryza sativa 4346856   Os09g0362800
Oryza sativa 4345501   Os08g0398700
Oryza sativa 4346854   Os09g0362500
Oryza sativa 4328737   Os02g0218200
Saccharomyces cerevisiae YKL157W   Ape2p
Saccharomyces cerevisiae YHR047C   Aap1p
Schistosoma japonicum Sjp_0041390   ko:K08776 puromycin-sensitive aminopeptidase, putative
Schistosoma mansoni Smp_091470   cytosol alanyl aminopeptidase (M01 family)
Schmidtea mediterranea mk4.002994.03  
Schmidtea mediterranea mk4.002994.02   Puromycin-sensitive aminopeptidase
Schmidtea mediterranea mk4.000189.08  
Schmidtea mediterranea mk4.033963.00  
Schmidtea mediterranea mk4.002994.00  
Schmidtea mediterranea mk4.040791.00  
Schmidtea mediterranea mk4.023315.00  
Trypanosoma brucei gambiense Tbg972.11.4060   aminopeptidase, putative,metallo-peptidase, Clan MA(E) Family M1
Trypanosoma brucei Tb927.11.3570   metallo-peptidase, Clan MA(E) Family M1
Trypanosoma congolense TcIL3000.11.3540   metallo-peptidase, Clan MA(E) Family M1
Trypanosoma cruzi TcCLB.509683.130   metallo-peptidase, clan MA(E), family M1, putative
Trypanosoma cruzi TcCLB.511051.70   aminopeptidase, putative
Toxoplasma gondii TGME49_262575   hypothetical protein
Trichomonas vaginalis TVAG_311790   Clan MA, family M1, aminopeptidase N-like metallopeptidase
Trichomonas vaginalis TVAG_008880   Clan MA, family M1, aminopeptidase N-like metallopeptidase

Essentiality

Rv2467 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.1070 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.1070 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.1070 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.1070 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F49E8.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T16G12.1 Caenorhabditis elegans embryonic lethal wormbase
TGME49_262575 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens aminopeptidase puromycin sensitive Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2467 (Mycobacterium tuberculosis), Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase)
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