Detailed view for Rv2511

Basic information

TDR Targets ID: 981624
Mycobacterium tuberculosis, Oligoribonuclease Orn
Source Database / ID:  Tuberculist 

pI: 4.2951 | Length (AA): 215 | MW (Da): 23410 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00929  

Gene Ontology

Mouse over links to read term descriptions.
GO:0004527   exonuclease activity  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 180 5cy4 (A) 6 182 42.00 0 1 1.37746 -0.7
2 179 1j9a (A) 8 183 44.00 0 1 1.41221 -0.62
2 179 2igi (A) 4 179 45.00 0 1 1.40521 -0.45
2 175 2gbz (A) 8 179 44.00 0 1 1.3966 -0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129087)

Species Accession Gene Product
Arabidopsis thaliana AT2G26970   polynucleotidyl transferase, ribonuclease H-like superfamily protein
Brugia malayi Bm1_35405   Smfn protein
Candida albicans CaO19.1466   RNA endonuclease
Candida albicans CaO19.9041   RNA endonuclease
Caenorhabditis elegans CELE_C08B6.8   Protein C08B6.8, isoform B
Dictyostelium discoideum DDB_G0273741   RNA exonuclease 2
Dictyostelium discoideum DDB_G0273355   RNA exonuclease 2
Drosophila melanogaster Dmel_CG10214   CG10214 gene product from transcript CG10214-RA
Escherichia coli b4162   oligoribonuclease
Homo sapiens ENSG00000076043   RNA exonuclease 2
Loa Loa (eye worm) LOAG_01772   smfn protein
Mycobacterium leprae ML0427c   Probable oligoribonuclease Orn
Mus musculus ENSMUSG00000032026   REX2, RNA exonuclease 2 homolog (S. cerevisiae)
Mycobacterium tuberculosis Rv2511   Oligoribonuclease Orn
Mycobacterium ulcerans MUL_3790   oligoribonuclease
Neospora caninum NCLIV_054180   Oligoribonuclease, related
Oryza sativa 9270337   Os04g0303950
Oryza sativa 4329319   Os02g0465500
Onchocerca volvulus OVOC11448   Putative oligoribonuclease
Saccharomyces cerevisiae YLR059C   Rex2p
Toxoplasma gondii TGME49_310060   small nuclease

Essentiality

Rv2511 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b4162 Escherichia coli essential goodall
YLR059C Saccharomyces cerevisiae inviable yeastgenome
TGME49_310060 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2511 (Mycobacterium tuberculosis), Oligoribonuclease Orn
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