pI: 5.1266 |
Length (AA): 372 |
MW (Da): 38759 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 372 | 3ctz (A) | 176 | 572 | 22.00 | 0 | 1 | 1.1981 | 0.41 |
4 | 133 | 5e2c (A) | 4 | 133 | 98.00 | 0 | 1 | 1.60736 | -2.01 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126673)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G29490 | metallopeptidase M24 family protein |
Arabidopsis thaliana | AT1G09300 | Metallopeptidase M24 family protein |
Brugia malayi | Bm1_08285 | Aminopeptidase P, N-terminal domain containing protein |
Brugia malayi | Bm1_41780 | metallopeptidase family M24 containing protein |
Candida albicans | CaO19.7987 | aminopeptidase |
Candida albicans | CaO19.354 | aminopeptidase |
Candida albicans | CaO19.7263 | potential metallopeptidase, similar to S. cerevisiae YFR006W |
Caenorhabditis elegans | CELE_R119.4 | Protein PQN-59 |
Caenorhabditis elegans | CELE_K12C11.1 | Protein K12C11.1 |
Caenorhabditis elegans | CELE_R119.2 | Protein R119.2 |
Chlamydia trachomatis | CT_574 | aminopeptidase P |
Dictyostelium discoideum | DDB_G0282075 | Xaa-Pro aminopeptidase 3 |
Dictyostelium discoideum | DDB_G0269382 | peptidase D |
Drosophila melanogaster | Dmel_CG9581 | CG9581 gene product from transcript CG9581-RA |
Drosophila melanogaster | Dmel_CG5663 | Dipeptidase C |
Escherichia coli | b2908 | proline aminopeptidase P II |
Escherichia coli | b2385 | Xaa-Pro aminopeptidase |
Echinococcus granulosus | EgrG_000621300 | xaa Pro dipeptidase |
Echinococcus granulosus | EgrG_000921400 | xaa Pro dipeptidase |
Echinococcus granulosus | EgrG_001034400 | Xaa Pro aminopeptidase 3 |
Entamoeba histolytica | EHI_010070 | Xaa-Pro dipeptidase, putative |
Entamoeba histolytica | EHI_140630 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000921400 | xaa Pro dipeptidase |
Echinococcus multilocularis | EmuJ_000621300 | xaa Pro dipeptidase |
Echinococcus multilocularis | EmuJ_001034400 | Xaa Pro aminopeptidase 3 |
Giardia lamblia | GL50803_17327 | Xaa-Pro dipeptidase |
Homo sapiens | ENSG00000196236 | X-prolyl aminopeptidase (aminopeptidase P) 3, putative |
Homo sapiens | ENSG00000124299 | peptidase D |
Leishmania braziliensis | LbrM.34.2300 | aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania donovani | LdBPK_352400.1 | aminopeptidase P, putative |
Leishmania infantum | LinJ.35.2400 | aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania major | LmjF.35.2350 | aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania mexicana | LmxM.34.2350 | aminopeptidase P, putative |
Loa Loa (eye worm) | LOAG_02414 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10174 | hypothetical protein |
Mycobacterium leprae | ML0521 | Probable cytoplasmic peptidase PepQ |
Mus musculus | ENSMUSG00000022401 | X-prolyl aminopeptidase (aminopeptidase P) 3, putative |
Mus musculus | ENSMUSG00000063931 | peptidase D |
Mycobacterium tuberculosis | Rv2535c | Probable cytoplasmic peptidase PepQ |
Mycobacterium tuberculosis | Rv2089c | Dipeptidase PepE |
Mycobacterium ulcerans | MUL_0331 | dipeptidase |
Mycobacterium ulcerans | MUL_0330 | aminopeptidase |
Mycobacterium ulcerans | MUL_2321 | dipeptidase PepE |
Mycobacterium ulcerans | MUL_1764 | cytoplasmic peptidase PepQ |
Neospora caninum | NCLIV_033100 | prolidase, putative |
Oryza sativa | 4328771 | Os02g0224400 |
Oryza sativa | 4352534 | Os12g0563500 |
Onchocerca volvulus | OVOC9023 | Dipeptidase C homolog |
Saccharomyces cerevisiae | YER078C | Icp55p |
Saccharomyces cerevisiae | YFR006W | putative Xaa-Pro dipeptidase |
Schistosoma japonicum | Sjp_0027920 | ko:K01271 X-Pro dipeptidase [EC3.4.13.9], putative |
Schistosoma mansoni | Smp_090800 | Xaa-Pro dipeptidase (M24 family) |
Schmidtea mediterranea | mk4.035850.00 | Aminopeptidase P homologue |
Schmidtea mediterranea | mk4.019619.00 | Dipeptidase C |
Schmidtea mediterranea | mk4.003379.02 | Xaa-Pro dipeptidase |
Trypanosoma brucei gambiense | Tbg972.9.8450 | aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 |
Trypanosoma brucei | Tb927.9.13490 | metallo-peptidase, Clan MG, Family M24 |
Trypanosoma congolense | TcIL3000_9_5720 | metallo-peptidase, Clan MG, Family M24 |
Trypanosoma cruzi | TcCLB.510749.99 | aminopeptidase P, putative |
Trypanosoma cruzi | TcCLB.510751.4 | aminopeptidase P, putative |
Trypanosoma cruzi | TcCLB.510655.120 | metallo-peptidase, Clan MG, Family M24, putative |
Toxoplasma gondii | TGME49_233310 | peptidase D, putative |
Trichomonas vaginalis | TVAG_255940 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Trichomonas vaginalis | TVAG_013490 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Trichomonas vaginalis | TVAG_040850 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Trichomonas vaginalis | TVAG_321430 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Trichomonas vaginalis | TVAG_403460 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Trichomonas vaginalis | TVAG_386080 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Trichomonas vaginalis | TVAG_227590 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Trichomonas vaginalis | TVAG_437930 | Clan MG, familly M24, aminopeptidase P-like metallopeptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2122 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb09.211.4330 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.4330 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.4330 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.4330 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2385 | Escherichia coli | non-essential | goodall |
b2908 | Escherichia coli | non-essential | goodall |
CELE_R119.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R119.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_R119.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K12C11.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K12C11.1 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_233310 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | peptidase D | Compounds | References |