pI: 6.2464 |
Length (AA): 583 |
MW (Da): 62124 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 125 | 3ocp (A) | 101 | 218 | 15.00 | 0 | 1 | 0.567017 | -1.23 |
13 | 124 | 5d1i (A) | 4 | 118 | 29.00 | 0.00000000019 | 1 | 0.67001 | -1.18 |
19 | 244 | 4ava (A) | 15 | 233 | 20.00 | 0.00000000027 | 1 | 0.54955 | 0.48 |
307 | 570 | 5fya (A) | 25 | 300 | 33.00 | 0 | 1 | 0.74673 | 0.29 |
307 | 581 | 5fya (A) | 25 | 311 | 29.00 | 0 | 1 | 0.714398 | 0.21 |
309 | 408 | 3tu3 (B) | 107 | 215 | 36.00 | 0.26 | 0.18 | 0.262427 | 1.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | murphy |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | hasan |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_128271)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_00930 | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative |
Candida albicans | CaO19.13754 | similar to S. cerevisiae YML059C predicted ER hydrolase |
Candida albicans | CaO19.6396 | similar to S. cerevisiae YML059C predicted ER hydrolase |
Caenorhabditis elegans | CELE_M110.7 | Protein M110.7 |
Caenorhabditis elegans | CELE_ZK370.4 | Protein ZK370.4, isoform A |
Drosophila melanogaster | Dmel_CG2212 | swiss cheese |
Escherichia coli | b1234 | putative patatin-like family phospholipase |
Echinococcus granulosus | EgrG_000199200 | patatin phospholipase domain containing protein |
Echinococcus multilocularis | EmuJ_000199200 | patatin phospholipase domain containing protein |
Homo sapiens | ENSG00000130653 | patatin-like phospholipase domain containing 7 |
Homo sapiens | ENSG00000032444 | patatin-like phospholipase domain containing 6 |
Loa Loa (eye worm) | LOAG_04599 | hypothetical protein |
Mus musculus | ENSMUSG00000004565 | patatin-like phospholipase domain containing 6 |
Mus musculus | ENSMUSG00000036833 | patatin-like phospholipase domain containing 7 |
Mycobacterium tuberculosis | Rv2565 | Conserved protein |
Onchocerca volvulus | OVOC7831 |
|
Saccharomyces cerevisiae | YML059C | Nte1p |
Schistosoma japonicum | Sjp_0108950 | expressed protein |
Schistosoma mansoni | Smp_171820.1 | neuropathy target esterase/swiss cheese-related protein |
Schistosoma mansoni | Smp_171820.2 | neuropathy target esterase/swiss cheese-related protein |
Schmidtea mediterranea | mk4.035485.00 | Neuropathy target esterase sws |
Schmidtea mediterranea | mk4.031677.00 | |
Schmidtea mediterranea | mk4.019462.00 | |
Schmidtea mediterranea | mk4.008911.01 | Neuropathy target esterase sws |
Treponema pallidum | TP1033 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2609 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
b1234 | Escherichia coli | non-essential | goodall |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | patatin-like phospholipase domain containing 6 | Compounds | References |