Detailed view for Rv2577

Basic information

TDR Targets ID: 980433
Mycobacterium tuberculosis, Conserved protein
Source Database / ID:  Tuberculist 

pI: 6.7353 | Length (AA): 529 | MW (Da): 57240 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149  

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0016787   hydrolase activity  
GO:0003993   acid phosphatase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
55 525 4kkz (A) 17 422 25.00 0 1 1.04126 -0.21
60 525 1xzw (A) 20 421 24.00 0 1 1.02881 -0.38
126 489 3zk4 (A) 218 546 32.00 0 1 0.767591 0.21
175 390 2bq8 (X) 1 224 29.00 0.000018 0.98 0.581818 0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_140005)

Species Accession Gene Product
Arabidopsis thaliana AT4G36350   purple acid phosphatase 25
Arabidopsis thaliana AT2G16430   purple acid phosphatase 10
Arabidopsis thaliana AT1G56360   purple acid phosphatase 6
Arabidopsis thaliana AT2G27190   Fe(3+)-Zn(2+) purple acid phosphatase 12
Dictyostelium discoideum DDB_G0272841   hypothetical protein
Mycobacterium tuberculosis Rv2577   Conserved protein
Oryza sativa 4327894   Os01g0776600
Oryza sativa 4352897   Os12g0637100

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Phaseolus vulgaris Fe(3+)-Zn(2+) purple acid phosphatase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0291 0.5063 1
0.028 0.3377 1
0.0158 0.5208 0.5298
0.0246 0.4939 0.8648

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2577 (Mycobacterium tuberculosis), Conserved protein
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