Detailed view for Rv2605c

Basic information

TDR Targets ID: 980892
Mycobacterium tuberculosis, Probable acyl-CoA thioesterase II TesB2 (TEII)
Source Database / ID:  Tuberculist 

pI: 6.4255 | Length (AA): 281 | MW (Da): 31537 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Biosynthesis of unsaturated fatty acids (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 276 3u0a (A) 2 276 86.00 0 1 1.93765 -0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129049)

Species Accession Gene Product
Arabidopsis thaliana AT1G01710   acyl-CoA thioesterase family protein
Arabidopsis thaliana AT4G00520   acyl-CoA thioesterase family protein
Candida albicans CaO19.11605   identical to nonallelic CaP19.5218, possible overlap with contig19-10221
Candida albicans CaO19.12683   one of five genes similar to acyl-CoA thioesterase
Candida albicans CaO19.5217   one of five genes similar to acyl-CoA thioesterase
Candida albicans CaO19.12684   one of five genes similar to acyl-CoA thioesterase
Candida albicans CaO19.4122   one of five genes similar to acyl-CoA thioesterase
Candida albicans CaO19.5216   one of five genes similar to acyl-CoA thioesterase
Caenorhabditis elegans CELE_C37H5.13   Protein C37H5.13, isoform C
Caenorhabditis elegans CELE_C17C3.1   Protein C17C3.1, isoform D
Caenorhabditis elegans CELE_F25E2.3   Protein F25E2.3
Escherichia coli b0452   acyl-CoA thioesterase 2
Homo sapiens ENSG00000101473   acyl-CoA thioesterase 8
Loa Loa (eye worm) LOAG_13498   hypothetical protein
Loa Loa (eye worm) LOAG_13373   hypothetical protein
Mycobacterium leprae ML1278   Probable acyl-CoA thioesterase II TesB
Mus musculus ENSMUSG00000017307   acyl-CoA thioesterase 8
Mycobacterium tuberculosis Rv1618   Probable acyl-CoA thioesterase II TesB1
Mycobacterium tuberculosis Rv2605c   Probable acyl-CoA thioesterase II TesB2 (TEII)
Mycobacterium ulcerans MUL_1599   acyl-CoA thioesterase II TesB1
Mycobacterium ulcerans MUL_3249   acyl-CoA thioesterase II TesB2
Oryza sativa 4336637   Os04g0558400
Onchocerca volvulus OVOC10131  
Saccharomyces cerevisiae YJR019C   Tes1p
Schistosoma japonicum Sjp_0051990   expressed protein
Schistosoma japonicum Sjp_0052000   ko:K01068 palmitoyl-CoA hydrolase [EC3.1.2.2], putative
Schistosoma mansoni Smp_150820   acyl-CoA thioesterase-related
Schmidtea mediterranea mk4.014754.02  
Trypanosoma cruzi TcCLB.504149.55   acyl-CoA thioesterase, putative

Essentiality

Rv2605c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0452 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2605c (Mycobacterium tuberculosis), Probable acyl-CoA thioesterase II TesB2 (TEII)
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