Detailed view for Rv2670c

Basic information

TDR Targets ID: 8690
Mycobacterium tuberculosis, Conserved hypothetical protein
Source Database / ID:  Tuberculist 

pI: 5.6344 | Length (AA): 369 | MW (Da): 39659 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03969   AFG1-like ATPase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 238 2qgz (A) 107 300 18.00 0 0.98 0.661215 0.01
84 120 5o0x (A) 492 530 43.00 0.16 0.29 0.256071 2.45
97 233 5he9 (A) 155 299 19.00 0.0088 0.74 0.582674 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_127572)

Species Accession Gene Product
Arabidopsis thaliana AT4G30490   AFG1-like ATPase family protein
Arabidopsis thaliana AT4G28070   AFG1-like ATPase family protein
Babesia bovis BBOV_III003940   ATPase, AFG1 family protein
Candida albicans CaO19.10409   one of two distinct genes similar to S. cerevisiae AFG1 (YEL052W) mitochondrial ATPase
Candida albicans CaO19.2891   one of two distinct genes similar to S. cerevisiae AFG1 (YEL052W) mitochondrial ATPase
Caenorhabditis elegans CELE_C30F12.2   Protein C30F12.2
Dictyostelium discoideum DDB_G0292852   AFG1-like ATPase
Drosophila melanogaster Dmel_CG8520   CG8520 gene product from transcript CG8520-RA
Escherichia coli b3232   putative AFG1-like family P-loop ATPase
Homo sapiens ENSG00000135537   lactation elevated 1
Leishmania braziliensis LbrM.05.1060   ATPase, putative
Leishmania donovani LdBPK_051060.1   ATPase, putative
Leishmania infantum LinJ.05.1060   ATPase, putative
Leishmania major LmjF.05.1060   ATPase, putative
Leishmania mexicana LmxM.05.1061   ATPase, putative
Leishmania mexicana LmxM.05.1060   ATPase, putative
Mus musculus ENSMUSG00000038302   lactation elevated 1
Mycobacterium tuberculosis Rv2670c   Conserved hypothetical protein
Mycobacterium ulcerans MUL_3304   hypothetical protein
Neospora caninum NCLIV_059290   hypothetical protein
Oryza sativa 4345118   Os08g0265500
Plasmodium berghei PBANKA_1236400   AFG1-like ATPase, putative
Plasmodium falciparum PF3D7_0521800   AFG1-like ATPase, putative
Plasmodium knowlesi PKNH_1011100   AFG1-like ATPase, putative
Plasmodium vivax PVX_080155   hypothetical protein, conserved
Plasmodium yoelii PY01368   hypothetical protein
Saccharomyces cerevisiae YEL052W   Afg1p
Schistosoma japonicum Sjp_0200270   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma mansoni Smp_015780   atpase n2b
Trypanosoma brucei gambiense Tbg972.7.8120   ATPase, putative
Trypanosoma brucei Tb927.7.6930   ATPase, putative
Trypanosoma congolense TcIL3000_7_5590   ATPase, putative
Trypanosoma cruzi TcCLB.506789.170   ATPase, putative
Trypanosoma cruzi TcCLB.508387.130   ATPase, putative
Toxoplasma gondii TGME49_217020   ATPase, AFG1 family protein
Theileria parva TP03_0013   nucleotide binding protein, putative

Essentiality

Rv2670c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu2716 this record Mycobacterium tuberculosis non-essential nmpdr
Tb927.7.6930 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.6930 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.6930 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.6930 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C30F12.2 Caenorhabditis elegans slow growth wormbase
PBANKA_1236400 Plasmodium berghei Dispensable plasmo
TGME49_217020 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv2670c (Mycobacterium tuberculosis), Conserved hypothetical protein
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