pI: 5.5409 |
Length (AA): 438 |
MW (Da): 47224 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 426 | 3cym (A) | 4 | 432 | 38.00 | 0 | 1 | 1.31041 | 0 |
246 | 326 | 2e1f (A) | 1151 | 1230 | 14.00 | 0 | 0.73 | 0.447132 | -0.93 |
249 | 321 | 1wud (A) | 533 | 605 | 19.00 | 0 | 0.99 | 0.496867 | -0.73 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127879)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G54440 | RRP6-like protein 1 |
Arabidopsis thaliana | AT5G35910 | exosome complex exonuclease RRP6L2 |
Babesia bovis | BBOV_IV002650 | exosome component 10, putative |
Brugia malayi | Bm1_09560 | 3'-5' exonuclease family protein |
Candida albicans | CaO19.7719 | likely 3'-5' exonuclease similar to S. cerevisiae RRP6 (YOR001W) nuclear exosome component involved in RNA processing |
Candida albicans | CaO19.58 | likely 3'-5' exonuclease similar to S. cerevisiae RRP6 (YOR001W) nuclear exosome component involved in RNA processing |
Caenorhabditis elegans | CELE_C14A4.4 | Protein CRN-3, isoform A |
Cryptosporidium hominis | Chro.50386 | hypothetical protein |
Dictyostelium discoideum | DDB_G0271572 | 3'-5' exonuclease |
Drosophila melanogaster | Dmel_CG7292 | CG7292 gene product from transcript CG7292-RC |
Escherichia coli | b1804 | ribonuclease D |
Echinococcus granulosus | EgrG_000568100 | Helicase RNase D C terminal HRDC domain |
Echinococcus granulosus | EgrG_002000900 | hypothetical protein |
Entamoeba histolytica | EHI_021400 | exosome component 10, putative |
Echinococcus multilocularis | EmuJ_000567700 | 3' 5' exonuclease |
Echinococcus multilocularis | EmuJ_000009300 | exosome component 10 |
Echinococcus multilocularis | EmuJ_000568100 | Helicase RNase D C terminal, HRDC domain |
Homo sapiens | ENSG00000171824 | exosome component 10 |
Leishmania braziliensis | LbrM.20.2660 | exosome subunit rrp6p homologue, putative |
Leishmania donovani | LdBPK_044330.1 | exosome subunit rrp6p homologue putative |
Leishmania infantum | LinJ.34.4330 | exosome subunit rrp6p homologue, putative |
Leishmania major | LmjF.34.3080 | exosome subunit rrp6p homologue, putative |
Leishmania mexicana | LmxM.33.3080 | exosome subunit rrp6p homologue, putative |
Loa Loa (eye worm) | LOAG_00677 | 3'-5' exonuclease |
Mycobacterium leprae | ML1040c | conserved hypothetical protein |
Mus musculus | ENSMUSG00000017264 | exosome component 10 |
Mycobacterium tuberculosis | Rv2681 | Conserved hypothetical alanine rich protein |
Mycobacterium ulcerans | MUL_3315 | hypothetical protein |
Neospora caninum | NCLIV_063640 | Ribonuclease D, related |
Oryza sativa | 4331677 | Os03g0157800 |
Oryza sativa | 9270208 | Os10g0437200 |
Saccharomyces cerevisiae | YOR001W | Rrp6p |
Schistosoma japonicum | Sjp_0206770 | Exosome component 10, putative |
Schistosoma mansoni | Smp_131150 | polymyositis/scleroderma autoantigen-related |
Schmidtea mediterranea | mk4.002369.05 | Polymyositis/scleroderma autoantigen-related |
Schmidtea mediterranea | mk4.002369.06 | Polymyositis/scleroderma autoantigen-related |
Trypanosoma brucei gambiense | Tbg972.4.1510 | ribosomal RNA processing protein 6, putative |
Trypanosoma brucei | Tb927.4.1630 | ribosomal RNA processing protein 6 |
Trypanosoma congolense | TcIL3000_4_1200 | ribosomal RNA processing protein 6, putative |
Trypanosoma cruzi | TcCLB.504057.110 | ribosomal RNA processing protein 6, putative |
Toxoplasma gondii | TGME49_246970 | 3'-5' exonuclease domain-containing protein |
Trichomonas vaginalis | TVAG_197890 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_283650 | hypothetical protein |
Trichomonas vaginalis | TVAG_053630 | conserved hypothetical protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0258 | ribonuclease D |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2727 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.4.1630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1630 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.1630 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C14A4.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C14A4.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C14A4.4 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_246970 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.