Detailed view for Rv2688c
Basic information
TDR Targets ID: 8701
Mycobacterium tuberculosis, Antibiotic-transport ATP-binding protein ABC transporter
Source Database / ID: Tuberculist
Mycobacterium tuberculosis, Antibiotic-transport ATP-binding protein ABC transporter
Source Database / ID: Tuberculist
pI: 6.5055 |
Length (AA): 301 |
MW (Da): 33100 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00005
ABC transporter
Gene Ontology
Mouse over links to read term descriptions.
GO:0017111
nucleoside-triphosphatase activity GO:0016887 ATPase activity
GO:0005524 ATP binding
GO:0000166 nucleotide binding
Metabolic Pathways
ABC transporters (KEGG)
Structural information
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 15 | 300 | 4yer (A) | 2 | 306 | 36.00 | 0 | 1 | 1.35067 | -0.41 |
| 17 | 248 | 1vpl (A) | 3 | 236 | 34.00 | 0 | 1 | 1.27686 | -0.93 |
| 18 | 244 | 4p32 (A) | 4 | 235 | 28.00 | 0 | 1 | 1.16425 | -0.77 |
| 34 | 300 | 4yer (A) | 19 | 306 | 40.00 | 0 | 1 | 1.32444 | -0.06 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | Dormant phase, Dormant phase. | hasan murphy |
-
murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. -
hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
Orthologs
Ortholog group members (OG5_126568)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT3G47780 | ABC transporter A family member 7 |
| Arabidopsis thaliana | AT2G41700 | ABC transporter A family member 1 |
| Arabidopsis thaliana | AT3G47770 | ABC transporter A family member 6 |
| Arabidopsis thaliana | AT5G61690 | ABC transporter A family member 11 |
| Arabidopsis thaliana | AT5G61740 | ABC transporter A family member 10 |
| Arabidopsis thaliana | AT3G47740 | ABC transporter A family member 3 |
| Arabidopsis thaliana | AT3G47730 | ABC transporter A family member 2 |
| Arabidopsis thaliana | AT5G61730 | ABC transporter A family member 9 |
| Arabidopsis thaliana | AT3G47750 | ABC transporter A family member 4 |
| Arabidopsis thaliana | AT5G61700 | ABC transporter A family member 12 |
| Arabidopsis thaliana | AT3G47760 | ABC transporter A family member 5 |
| Arabidopsis thaliana | AT3G47790 | ABC transporter A family member 8 |
| Brugia malayi | Bm1_33910 | ABC transporter family protein |
| Brugia malayi | Bm1_48200 | ABC transporter family protein |
| Caenorhabditis elegans | CELE_Y53C10A.9 | Protein ABT-5 |
| Caenorhabditis elegans | CELE_Y39D8C.1 | Protein ABT-4 |
| Caenorhabditis elegans | CELE_F12B6.1 | Protein ABT-2 |
| Caenorhabditis elegans | CELE_C48B4.4 | Protein CED-7, isoform A |
| Dictyostelium discoideum | DDB_G0271138 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0291245 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0293436 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0274119 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0271140 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0291994 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0267438 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0291980 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0275453 | ABC transporter A family protein |
| Dictyostelium discoideum | DDB_G0274121 | ABC transporter A family protein |
| Drosophila melanogaster | Dmel_CG42816 | CG42816 gene product from transcript CG42816-RB |
| Drosophila melanogaster | Dmel_CG6052 | CG6052 gene product from transcript CG6052-RA |
| Drosophila melanogaster | Dmel_CG31731 | CG31731 gene product from transcript CG31731-RB |
| Drosophila melanogaster | Dmel_CG34120 | CG34120 gene product from transcript CG34120-RE |
| Drosophila melanogaster | Dmel_CG1718 | CG1718 gene product from transcript CG1718-RB |
| Drosophila melanogaster | Dmel_CG42815 | CG42815 gene product from transcript CG42815-RA |
| Drosophila melanogaster | Dmel_CG8908 | CG8908 gene product from transcript CG8908-RE |
| Escherichia coli | b0127 | putative ABC superfamily transporter ATP-binding subunit |
| Escherichia coli | b0794 | putative transporter subunit of ABC superfamily: ATP-binding component |
| Echinococcus granulosus | EgrG_000519900 | ATP binding cassette sub family A |
| Entamoeba histolytica | EHI_197670 | ABC transporter, putative |
| Entamoeba histolytica | EHI_112010 | ABC transporter, putative |
| Echinococcus multilocularis | EmuJ_000519900 | ATP binding cassette sub family A |
| Giardia lamblia | GL50803_3470 | ABC transporter family protein |
| Giardia lamblia | GL50803_16575 | ABC transporter family protein |
| Giardia lamblia | GL50803_8227 | ATP-binding cassette protein 5 |
| Giardia lamblia | GL50803_92223 | ABC transporter family protein |
| Homo sapiens | ENSG00000154265 | ATP-binding cassette, sub-family A (ABC1), member 5 |
| Homo sapiens | ENSG00000107331 | ATP-binding cassette, sub-family A (ABC1), member 2 |
| Homo sapiens | ENSG00000144452 | ATP-binding cassette, sub-family A (ABC1), member 12 |
| Homo sapiens | ENSG00000179869 | ATP-binding cassette, sub-family A (ABC1), member 13 |
| Homo sapiens | ENSG00000064687 | ATP-binding cassette, sub-family A (ABC1), member 7 |
| Homo sapiens | ENSG00000198691 | ATP-binding cassette, sub-family A (ABC1), member 4 |
| Homo sapiens | ENSG00000141338 | ATP-binding cassette, sub-family A (ABC1), member 8 |
| Homo sapiens | ENSG00000154258 | ATP-binding cassette, sub-family A (ABC1), member 9 |
| Homo sapiens | ENSG00000167972 | ATP-binding cassette, sub-family A (ABC1), member 3 |
| Homo sapiens | ENSG00000154262 | ATP-binding cassette, sub-family A (ABC1), member 6 |
| Homo sapiens | ENSG00000154263 | ATP-binding cassette, sub-family A (ABC1), member 10 |
| Homo sapiens | ENSG00000165029 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| Leishmania braziliensis | LbrM.15.0820 | ABC1 transporter-like protein |
| Leishmania braziliensis | LbrM.29.0630 | ABC transporter, putative |
| Leishmania braziliensis | LbrM.11.1020 | ABC transporter, putative |
| Leishmania braziliensis | LbrM.27.1050 | ABC transporter, putative |
| Leishmania braziliensis | LbrM.11.1000 | ABC1 transporter, putative |
| Leishmania braziliensis | LbrM.11.0960 | ABC transporter, putative |
| Leishmania braziliensis | LbrM.11.1040 | ABC transporter, putative |
| Leishmania braziliensis | LbrM.11.1010 | ABC1 transporter, putative |
| Leishmania braziliensis | LbrM.02.0350 | ABC1 transporter, putative |
| Leishmania donovani | LdBPK_111210.1 | ATP-binding cassette protein subfamily A, member 2, putative |
| Leishmania donovani | LdBPK_111280.1 | ATP-binding cassette protein subfamily A, member 6, putative |
| Leishmania donovani | LdBPK_020270.1 | ABC1 transporter, putative |
| Leishmania donovani | LdBPK_150800.1 | ATP-binding cassette protein subfamily A, member 7, putative |
| Leishmania donovani | LdBPK_290640.1 | ATP-binding cassette protein subfamily A, member 10, putative |
| Leishmania donovani | LdBPK_270840.1 | ATP-binding cassette protein subfamily A, member 9, putative |
| Leishmania donovani | LdBPK_111260.1 | ATP-binding cassette protein subfamily A, member 5, putative |
| Leishmania infantum | LinJ.02.0270 | ABC1 transporter, putative |
| Leishmania infantum | LinJ.11.1230 | ATP-binding cassette protein subfamily A, member 3, putative |
| Leishmania infantum | LinJ.11.1240 | ATP-binding cassette protein subfamily A, member 4, putative |
| Leishmania infantum | LinJ.11.1260 | ATP-binding cassette protein subfamily A, member 5, putative |
| Leishmania infantum | LinJ.11.1210 | ATP-binding cassette protein subfamily A, member 2, putative |
| Leishmania infantum | LinJ.29.0640 | ATP-binding cassette protein subfamily A, member 10, putative,ABC transporter, putative |
| Leishmania infantum | LinJ.27.0840 | ATP-binding cassette protein subfamily A, member 9, putative |
| Leishmania infantum | LinJ.11.1280 | ATP-binding cassette protein subfamily A, member 6, putative |
| Leishmania infantum | LinJ.27.0830 | ATP-binding cassette protein subfamily A, member 8, putative |
| Leishmania infantum | LinJ.11.1220 | ABC transporter-like protein |
| Leishmania major | LmjF.15.0760 | ATP-binding cassette protein subfamily A, member 7, putative |
| Leishmania major | LmjF.11.1290 | ATP-binding cassette protein subfamily A, member 6, putative |
| Leishmania major | LmjF.27.0980 | ATP-binding cassette protein subfamily A, member 9, putative |
| Leishmania major | LmjF.11.1250 | ATP-binding cassette protein subfamily A, member 4, putative |
| Leishmania major | LmjF.11.1270 | ATP-binding cassette protein subfamily A, member 5, putative |
| Leishmania major | LmjF.11.1240 | ATP-binding cassette protein subfamily A, member 3, putative |
| Leishmania major | LmjF.11.1220 | ATP-binding cassette protein subfamily A, member 2, putative |
| Leishmania major | LmjF.02.0300 | ATP-binding cassette subfamily A, member 1, putative |
| Leishmania major | LmjF.29.0620 | ATP-binding cassette protein subfamily A, member 10, putative,ABC transporter, putative |
| Leishmania major | LmjF.27.0970 | ATP-binding cassette protein subfamily A, member 8, putative |
| Leishmania mexicana | LmxM.11.1250 | ATP-binding cassette protein subfamily A, member 4, putative |
| Leishmania mexicana | LmxM.15.0760 | ABC1 transporter-like protein |
| Leishmania mexicana | LmxM.11.1270 | ABC transporter, putative |
| Leishmania mexicana | LmxM.27.0980 | ATP-binding cassette protein subfamily A, member 9, putative |
| Leishmania mexicana | LmxM.11.1220a | |
| Leishmania mexicana | LmxM.27.0970 | ABC transporter, putative |
| Leishmania mexicana | LmxM.11.1220 | ATP-binding cassette protein subfamily A, member 2, putative |
| Leishmania mexicana | LmxM.11.1240 | ABC1 transporter, putative |
| Leishmania mexicana | LmxM.02.0300 | ABC1 transporter, putative |
| Leishmania mexicana | LmxM.08_29.0620 | ABC transporter, putative |
| Leishmania mexicana | LmxM.11.1290 | ABC transporter, putative |
| Loa Loa (eye worm) | LOAG_07764 | RIM ABC transporter |
| Loa Loa (eye worm) | LOAG_01727 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_00011 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_01325 | RIM ABC transporter |
| Loa Loa (eye worm) | LOAG_09131 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_00012 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_00013 | hypothetical protein |
| Mycobacterium leprae | ML0590c | Possible unidentified antibiotic-transport ATP-binding protein ABC transporter |
| Mycobacterium leprae | ML2352c | PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA |
| Mus musculus | ENSMUSG00000026944 | ATP-binding cassette, sub-family A (ABC1), member 2 |
| Mus musculus | ENSMUSG00000035722 | ATP-binding cassette, sub-family A (ABC1), member 7 |
| Mus musculus | ENSMUSG00000044749 | ATP-binding cassette, sub-family A (ABC1), member 6 |
| Mus musculus | ENSMUSG00000041797 | ATP-binding cassette, sub-family A (ABC1), member 9 |
| Mus musculus | ENSMUSG00000054746 | ATP-binding cassette, sub-family A (ABC1), member 15 |
| Mus musculus | ENSMUSG00000024130 | ATP-binding cassette, sub-family A (ABC1), member 3 |
| Mus musculus | ENSMUSG00000062017 | ATP-binding cassette, sub-family A (ABC1), member 14 |
| Mus musculus | ENSMUSG00000020620 | ATP-binding cassette, sub-family A (ABC1), member 8b |
| Mus musculus | ENSMUSG00000050296 | ATP-binding cassette, sub-family A (ABC1), member 12 |
| Mus musculus | ENSMUSG00000051900 | ATP-binding cassette, sub-family A (ABC1), member 16 |
| Mus musculus | ENSMUSG00000035435 | ATP-binding cassette, sub-family A (ABC1), member 17 |
| Mus musculus | ENSMUSG00000015243 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| Mus musculus | ENSMUSG00000018800 | ATP-binding cassette, sub-family A (ABC1), member 5 |
| Mus musculus | ENSMUSG00000028125 | ATP-binding cassette, sub-family A (ABC1), member 4 |
| Mus musculus | ENSMUSG00000041828 | ATP-binding cassette, sub-family A (ABC1), member 8a |
| Mus musculus | ENSMUSG00000004668 | ATP-binding cassette, sub-family A (ABC1), member 13 |
| Mycobacterium tuberculosis | Rv2936 | Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA |
| Mycobacterium tuberculosis | Rv1458c | Probable unidentified antibiotic-transport ATP-binding protein ABC transporter |
| Mycobacterium tuberculosis | Rv2688c | Antibiotic-transport ATP-binding protein ABC transporter |
| Mycobacterium ulcerans | MUL_2014 | daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA |
| Mycobacterium ulcerans | MUL_1859 | antibiotic ABC transporter ATP-binding protein |
| Mycobacterium ulcerans | MUL_3577 | ABC transporter ATP-binding protein |
| Mycobacterium ulcerans | MUL_4925 | ABC transporter ATP-binding protein |
| Oryza sativa | 9269712 | Os09g0360900 |
| Oryza sativa | 4345498 | Os08g0398300 |
| Oryza sativa | 4341405 | Os06g0589300 |
| Oryza sativa | 9269177 | Os08g0398350 |
| Oryza sativa | 4328702 | Os02g0211000 |
| Oryza sativa | 4345497 | Os08g0398000 |
| Onchocerca volvulus | OVOC1131 |
|
| Onchocerca volvulus | OVOC2635 |
|
| Schistosoma japonicum | Sjp_0045340 | Retinal-specific ATP-binding cassette transporter, putative |
| Schistosoma japonicum | Sjp_0066190 | hypothetical protein |
| Schistosoma japonicum | Sjp_0131960 | ko:K05313 glutamate receptor, ionotropic, invertebrate, putative |
| Schistosoma japonicum | Sjp_0045330 | ko:K05641 ATP-binding cassette, subfamily A (ABC1), member 1, putative |
| Schistosoma japonicum | Sjp_0045320 | ATP-binding cassette sub-family A member 7, putative |
| Schistosoma mansoni | Smp_165800 | ATP-binding cassette transporter |
| Schistosoma mansoni | Smp_056290 | hypothetical protein |
| Schmidtea mediterranea | mk4.021331.00 | |
| Schmidtea mediterranea | mk4.000387.03 | ATP-binding cassette sub-family A member 3 |
| Schmidtea mediterranea | mk4.000064.03 | |
| Schmidtea mediterranea | mk4.000064.16 | |
| Schmidtea mediterranea | mk4.006329.01 | |
| Schmidtea mediterranea | mk4.000574.05 | |
| Schmidtea mediterranea | mk4.000574.02 | |
| Schmidtea mediterranea | mk4.004625.02 | |
| Schmidtea mediterranea | mk4.009812.00 | |
| Schmidtea mediterranea | mk4.000064.04 | |
| Schmidtea mediterranea | mk4.002984.00 | |
| Schmidtea mediterranea | mk4.000387.01 | |
| Schmidtea mediterranea | mk4.000411.03 | |
| Schmidtea mediterranea | mk4.001335.01 | |
| Schmidtea mediterranea | mk4.003586.01 | |
| Schmidtea mediterranea | mk4.000574.04 | |
| Schmidtea mediterranea | mk4.000862.03 | |
| Schmidtea mediterranea | mk4.000033.05 | |
| Trypanosoma brucei gambiense | Tbg972.11.6880 | ABC transporter, putative |
| Trypanosoma brucei gambiense | Tbg972.3.4040 | ABC transporter, putative |
| Trypanosoma brucei | Tb11.v5.0780 | ABC transporter, putative |
| Trypanosoma brucei | Tb927.11.6120 | ABC transporter, putative |
| Trypanosoma brucei | Tb927.3.3730 | ABC transporter, putative |
| Trypanosoma congolense | TcIL3000.11.6660 | ABC transporter, putative |
| Trypanosoma congolense | TcIL3000_3_2420 | ABC transporter, putative |
| Trypanosoma congolense | TcIL3000.11.6640 | ABC transporter, putative |
| Trypanosoma cruzi | TcCLB.510149.80 | ABC transporter, putative |
| Trypanosoma cruzi | TcCLB.506989.30 | ABC transporter, putative |
| Trypanosoma cruzi | TcCLB.507099.80 | ABC transporter, putative |
| Trypanosoma cruzi | TcCLB.510045.20 | ABC transporter, putative |
| Trypanosoma cruzi | TcCLB.503573.9 | ATP-binding cassette transporter ABCA1, putative |
| Trypanosoma cruzi | TcCLB.504881.50 | ABC transporter, putative |
| Trypanosoma cruzi | TcCLB.504149.20 | ATP-binding cassette transporter ABCA1, putative |
| Treponema pallidum | TP0881 | ABC transporter, ATP-binding protein (natA) |
| Trichomonas vaginalis | TVAG_274600 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_415980 | abca7, putative |
| Trichomonas vaginalis | TVAG_225860 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_117420 | abca1, putative |
| Trichomonas vaginalis | TVAG_461460 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_006570 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_208810 | abca5, putative |
| Trichomonas vaginalis | TVAG_222590 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_132360 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_178220 | abca4, putative |
| Trichomonas vaginalis | TVAG_173120 | abca9, putative |
| Trichomonas vaginalis | TVAG_245220 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_367650 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_024550 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_275420 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_059100 | abca6, putative |
| Trichomonas vaginalis | TVAG_225870 | abca2, putative |
| Trichomonas vaginalis | TVAG_033260 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_222600 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_151030 | abca10, putative |
| Trichomonas vaginalis | TVAG_064700 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_218950 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_225890 | Phosphonates import ATP-binding protein phnC, putative |
| Trichomonas vaginalis | TVAG_064710 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_072430 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_461330 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_033020 | abca6, putative |
| Trichomonas vaginalis | TVAG_415970 | abca1, putative |
| Trichomonas vaginalis | TVAG_478620 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_432320 | abca12, putative |
| Trichomonas vaginalis | TVAG_367660 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_510260 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_006590 | abca2, putative |
| Trichomonas vaginalis | TVAG_072420 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_353220 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_461030 | abca6, putative |
| Trichomonas vaginalis | TVAG_225880 | abca2, putative |
| Trichomonas vaginalis | TVAG_160130 | abca5, putative |
| Trichomonas vaginalis | TVAG_299600 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_432310 | abca4, putative |
| Trichomonas vaginalis | TVAG_245200 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_440500 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_254060 | metal ABC transporter, putative |
| Trichomonas vaginalis | TVAG_006580 | ATP binding cassete (ABC) transporter, putative |
| Trichomonas vaginalis | TVAG_006600 | abca8, putative |
| Trichomonas vaginalis | TVAG_419370 | abca12, putative |
| Trichomonas vaginalis | TVAG_160140 | abca1, putative |
| Trichomonas vaginalis | TVAG_419360 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_045530 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_461020 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_440490 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_364970 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_072410 | conserved hypothetical protein |
| Trichomonas vaginalis | TVAG_248260 | ATP binding cassete (ABC) transporter, putative |
| Trichomonas vaginalis | TVAG_136030 | ABC transporter, putative |
| Trichomonas vaginalis | TVAG_481000 | ABC transporter, putative |
Essentiality
Rv2688c has direct evidence of essentiality
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| mtu2984 | Mycobacterium tuberculosis | non-essential | nmpdr |
| mtu2734 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
| Tb927.3.3730 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.3.3730 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.3.3730 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.3.3730 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb11.02.3950 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
| Tb11.02.3950 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb11.02.3950 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb11.02.3950 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| b0127 | Escherichia coli | non-essential | goodall |
| b0794 | Escherichia coli | non-essential | goodall |
| CELE_F12B6.1 | Caenorhabditis elegans | slow growth | wormbase |
-
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Druggability index (range: 0 to 1): 0.4
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Mus musculus | ATP-binding cassette, sub-family A (ABC1), member 1 | Compounds | References |
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
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