pI: 10.5675 |
Length (AA): 162 |
MW (Da): 17437 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 82 | 2vqe (P) | 2 | 82 | 51.00 | 0 | 1 | 1.23093 | -1.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase, Dormant phase. | hasan murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_127603)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthCp004 | ribosomal protein S16 |
Arabidopsis thaliana | AT5G56940 | ribosomal protein S16 family protein |
Arabidopsis thaliana | AT4G34620 | small subunit ribosomal protein 16 |
Brugia malayi | Bm1_43310 | 28S ribosomal protein S16, mitochondrial precursor, putative |
Candida albicans | CaO19.7012 | likely mitochondrial ribosomal protein similar to S. cerevisiae MRPS16 (YPL013C) small subunit protein S16 |
Candida albicans | CaO19_7012 | hypothetical protein |
Caenorhabditis elegans | CELE_F56D1.3 | Protein MRPS-16 |
Chlamydia trachomatis | CT_026 | 30S ribosomal protein S16 |
Drosophila melanogaster | Dmel_CG8338 | mitochondrial ribosomal protein S16 |
Escherichia coli | b2609 | 30S ribosomal subunit protein S16 |
Echinococcus granulosus | EgrG_000576000 | 28S ribosomal protein S16 |
Echinococcus multilocularis | EmuJ_000576000 | 28S ribosomal protein S16 |
Homo sapiens | ENSG00000182180 | mitochondrial ribosomal protein S16 |
Loa Loa (eye worm) | LOAG_10356 | 28S ribosomal protein S16 |
Mycobacterium leprae | ML1618c | PROBABLE 30S RIBOSOMAL PROTEIN S16 RPSP |
Mus musculus | ENSMUSG00000049960 | mitochondrial ribosomal protein S16 |
Mycobacterium tuberculosis | Rv2909c | 30S ribosomal protein S16 RpsP |
Mycobacterium ulcerans | MUL_2047 | 30S ribosomal protein S16 |
Oryza sativa | 3131439 | ribosomal protein S16 |
Oryza sativa | 4346044 | Os08g0517900 |
Oryza sativa | 4347467 | Os09g0498100 |
Saccharomyces cerevisiae | YPL013C | mitochondrial 37S ribosomal protein MRPS16 |
Schistosoma japonicum | Sjp_0216120 | Probable mitochondrial 28S ribosomal protein S16, putative |
Schistosoma mansoni | Smp_066480 | 28S ribosomal protein S16 |
Schmidtea mediterranea | mk4.031738.02 | |
Schmidtea mediterranea | mk4.001309.00 | Probable 28S ribosomal protein S16, mitochondrial |
Treponema pallidum | TP0905 | ribosomal protein S16 (rpsP) |
Wolbachia endosymbiont of Brugia malayi | Wbm0531 | 30S ribosomal protein S16 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2956 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
b2609 | Escherichia coli | essential | goodall |
CELE_F56D1.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F56D1.3 | Caenorhabditis elegans | slow growth | wormbase |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.