pI: 8.0848 |
Length (AA): 525 |
MW (Da): 54969 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 445 | 3ndb (B) | 3 | 449 | 36.00 | 0 | 1 | 1.22351 | -0.23 |
4 | 436 | 2xxa (A) | 4 | 432 | 51.00 | 0 | 1 | 1.36766 | 0.04 |
24 | 302 | 5l3r (A) | 100 | 371 | 52.00 | 0 | 1 | 1.20833 | -1.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126863)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G03940 | chloroplast signal recognition particle 54 |
Arabidopsis thaliana | AT1G15310 | signal recognition particle protein SRP54A |
Arabidopsis thaliana | AT1G48900 | signal recognition particle subunit SRP54 |
Arabidopsis thaliana | AT5G49500 | Signal recognition particle SRP54 subunit protein |
Babesia bovis | BBOV_IV009210 | signal recognition particle SRP54 protein, putative |
Brugia malayi | Bm1_17780 | signal recognition particle 54 kDa protein (SRP54), putative |
Candida albicans | CaO19.3243 | Signal recognition particle subunit |
Candida albicans | CaO19.10753 | Signal recognition particle subunit |
Caenorhabditis elegans | CELE_F21D5.7 | Protein F21D5.7 |
Cryptosporidium hominis | Chro.70193 | signal recognition particle protein SRP54 |
Cryptosporidium parvum | cgd7_1640 | SRP54. signal recognition 54. GTpase. |
Chlamydia trachomatis | CT_025 | signal recognition particle GTPase |
Dictyostelium discoideum | DDB_G0275455 | signal recognition particle 54 kDa subunit |
Drosophila melanogaster | Dmel_CG4659 | Signal recognition particle protein 54k |
Escherichia coli | b2610 | Signal Recognition Particle (SRP) component with 4.5S RNA (ffs) |
Echinococcus granulosus | EgrG_000163100 | signal recognition particle 54 kda protein |
Entamoeba histolytica | EHI_004750 | signal recognition particle protein SRP54, putative |
Echinococcus multilocularis | EmuJ_000163100 | signal recognition particle 54 kda protein |
Giardia lamblia | GL50803_15156 | SRP GTPase |
Homo sapiens | ENSG00000100883 | signal recognition particle 54kDa |
Leishmania braziliensis | LbrM.24.0740 | signal recognition particle, putative |
Leishmania donovani | LdBPK_240740.1 | signal recognition particle, putative |
Leishmania infantum | LinJ.24.0740 | signal recognition particle, putative |
Leishmania major | LmjF.24.0730 | signal recognition particle, putative |
Leishmania mexicana | LmxM.24.0730 | signal recognition particle, putative |
Loa Loa (eye worm) | LOAG_06790 | signal recognition particle protein |
Mycobacterium leprae | ML1622c | PROBABLE SIGNAL RECOGNITION PARTICLE PROTEIN FFH (FIFTY-FOUR HOMOLOG) (SRP PROTEIN) |
Mus musculus | ENSMUSG00000079108 | signal recognition particle 54B |
Mus musculus | 24067 | signal recognition particle 54A |
Mus musculus | ENSMUSG00000079108 | signal recognition particle 54C |
Mycobacterium tuberculosis | Rv2916c | Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein) |
Mycobacterium ulcerans | MUL_2040 | signal recognition particle protein Ffh |
Neospora caninum | NCLIV_056440 | Signal recognition particle GTPase, related |
Oryza sativa | 4324712 | Os01g0772800 |
Oryza sativa | 9267495 | Os11g0153600 |
Oryza sativa | 4349809 | Os11g0153700 |
Oryza sativa | 4339274 | Os05g0509500 |
Onchocerca volvulus | OVOC7330 | Signal recognition particle 54 kDa protein homolog |
Plasmodium berghei | PBANKA_1313800 | signal recognition particle subunit SRP54, putative |
Plasmodium falciparum | PF3D7_1450100 | signal recognition particle subunit SRP54 |
Plasmodium knowlesi | PKNH_1232000 | signal recognition particle subunit SRP54, putative |
Plasmodium vivax | PVX_117980 | signal recognition particle subunit SRP54, putative |
Plasmodium yoelii | PY06341 | signal recognition particle protein SRP54 |
Saccharomyces cerevisiae | YPR088C | Srp54p |
Schistosoma japonicum | Sjp_0079590 | ko:K03106 signal recognition particle, subunit SRP54, putative |
Schistosoma japonicum | Sjp_0112730 | similar to Signal recognition particle 54 kDa protein, putative |
Schistosoma mansoni | Smp_059540 | signal recognition particle 54 kD protein |
Schmidtea mediterranea | mk4.034628.01 | Signal recognition particle 54 kDa protein |
Schmidtea mediterranea | mk4.002132.04 | Putative signal recognition particle 54 kD protein |
Trypanosoma brucei gambiense | Tbg972.11.6090 | signal recognition particle 54 kDa, putative |
Trypanosoma brucei | Tb927.11.5400 | signal recognition particle 54 kDa |
Trypanosoma congolense | TcIL3000.11.5640 | signal recognition particle 54 kDa |
Trypanosoma cruzi | TcCLB.505183.80 | signal recognition particle, putative |
Toxoplasma gondii | TGME49_313100 | signal recognition particle SRP54 protein |
Treponema pallidum | TP0416 | signal recognition particle protein (ffh) |
Theileria parva | TP01_0852 | signal recognition particle 54 kDa protein, putative |
Trichomonas vaginalis | TVAG_335890 | signal recognition particle receptor alpha subunit, putative |
Trichomonas vaginalis | TVAG_028560 | signal recognition particle protein, putative |
Trichomonas vaginalis | TVAG_027020 | cell division protein ftsy, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0049 | Signal recognition particle GTPase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3070 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3070 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3070 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb11.02.3070 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2610 | Escherichia coli | essential | goodall |
CELE_F21D5.7 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F21D5.7 | Caenorhabditis elegans | sterile | wormbase |
YPR088C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_313100 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.