pI: 6.3631 |
Length (AA): 376 |
MW (Da): 40135 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
33 | 369 | 4c89 (A) | 0 | 336 | 24.00 | 0 | 1 | 1.14868 | -0.14 |
61 | 371 | 5lk6 (A) | 3 | 299 | 41.00 | 0 | 1 | 1.36813 | -0.89 |
100 | 371 | 3zwq (A) | 43 | 309 | 43.00 | 0 | 1 | 1.3131 | -1.06 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase, Dormant phase. | hasan murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_126961)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G05120 | putative gibberellin receptor GID1L1 |
Arabidopsis thaliana | AT5G23530 | carboxyesterase 18 |
Arabidopsis thaliana | AT5G27320 | gibberellin receptor GID1C |
Arabidopsis thaliana | AT5G06570 | probable carboxylesterase 15 |
Brugia malayi | Bm1_32020 | aryl-acylamidase |
Caenorhabditis elegans | CELE_F16F9.4 | Protein F16F9.4 |
Cryptosporidium hominis | Chro.40044 | hypothetical protein |
Cryptosporidium parvum | cgd4_300 | lipase/esterase, putative |
Dictyostelium discoideum | DDB_G0283819 | hypothetical protein |
Dictyostelium discoideum | DDB_G0286925 | esterase/lipase/thioesterase domain-containing protein |
Escherichia coli | b0476 | acetyl esterase |
Homo sapiens | ENSG00000114771 | arylacetamide deacetylase |
Homo sapiens | ENSG00000197953 | arylacetamide deacetylase-like 2 |
Loa Loa (eye worm) | LOAG_13843 | aryl-acylamidase |
Mus musculus | ENSMUSG00000036951 | RIKEN cDNA C130079G13 gene |
Mus musculus | ENSMUSG00000078506 | predicted gene 13124 |
Mus musculus | ENSMUSG00000027761 | arylacetamide deacetylase (esterase) |
Mus musculus | 669780 | predicted gene, 16527 |
Mus musculus | 435732 | predicted gene 5709 |
Mus musculus | ENSMUSG00000091376 | arylacetamide deacetylase-like 2 |
Mus musculus | ENSMUSG00000095522 | predicted gene 8298 |
Mus musculus | ENSMUSG00000090527 | predicted gene 5538 |
Mycobacterium tuberculosis | Rv1399c | Probable non lipolytic carboxylesterase NlhH |
Mycobacterium tuberculosis | Rv1400c | Probable lipase LipH |
Mycobacterium tuberculosis | Rv2970c | Probable lipase/esterase LipN |
Mycobacterium tuberculosis | Rv0217c | Possible esterase LipW |
Mycobacterium ulcerans | MUL_3141 | esterase/lipase |
Mycobacterium ulcerans | MUL_1794 | lipase LipH |
Mycobacterium ulcerans | MUL_1054 | esterase LipW |
Mycobacterium ulcerans | MUL_1795 | lipase LipI |
Mycobacterium ulcerans | MUL_1989 | lipase/esterase LipN |
Neospora caninum | NCLIV_015570 | alpha/beta hydrolase fold domain containing protein, putative |
Oryza sativa | 4324508 | Os01g0153800 |
Oryza sativa | 4340844 | Os06g0306600 |
Oryza sativa | 9268360 | Os07g0643000 |
Oryza sativa | 4342460 | Os07g0162400 |
Oryza sativa | 4344083 | Os07g0643700 |
Oryza sativa | 9270235 | Os07g0643601 |
Oryza sativa | 4343857 | Os07g0606800 |
Oryza sativa | 4334379 | Os03g0790500 |
Oryza sativa | 4342464 | Os07g0162900 |
Oryza sativa | 4344081 | Os07g0643400 |
Oryza sativa | 9267725 | Os11g0239600 |
Oryza sativa | 4350163 | Os11g0240000 |
Oryza sativa | 4324077 | Os01g0155000 |
Oryza sativa | 4342461 | Os07g0162500 |
Oryza sativa | 4344080 | Os07g0643100 |
Oryza sativa | 4342463 | Os07g0162700 |
Oryza sativa | 4342462 | Os07g0162600 |
Oryza sativa | 4338764 | Os05g0407500 |
Oryza sativa | 4350164 | Os11g0240600 |
Oryza sativa | 4324076 | Os01g0154900 |
Onchocerca volvulus | OVOC3365 |
|
Toxoplasma gondii | TGME49_238200 | alpha/beta hydrolase fold domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1422 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1423 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3019 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
b0476 | Escherichia coli | non-essential | goodall |
TGME49_238200 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | arylacetamide deacetylase | Compounds | References |
51 literature references were collected for this gene.