pI: 9.1151 |
Length (AA): 227 |
MW (Da): 24449 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 227 | 4wpk (A) | 1 | 227 | 99.99 | 0 | 1 | 2.2988 | -2.09 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127417)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G18630 | uracil DNA glycosylase |
Babesia bovis | BBOV_III006230 | uracil-DNA glycosylase family protein |
Brugia malayi | Bm1_45505 | Uracil-DNA glycosylase |
Candida albicans | CaO19.7425 | uracil-DNA-glycosylase |
Cryptosporidium hominis | Chro.70188 | uracil-DNA glycosylase |
Cryptosporidium parvum | cgd7_1590 | uracil-DNA glycosylase, putative |
Chlamydia trachomatis | CT_607 | uracil DNA glycosylase |
Dictyostelium discoideum | DDB_G0273013 | uracil glycosylase |
Dictyostelium discoideum | DDB_G0277877 | uracil glycosylase |
Escherichia coli | b2580 | uracil-DNA-glycosylase |
Echinococcus granulosus | EgrG_000855500 | uracil DNA glycosylase |
Entamoeba histolytica | EHI_178910 | uracil-DNA glycosylase, putative |
Echinococcus multilocularis | EmuJ_000855500 | uracil DNA glycosylase |
Homo sapiens | ENSG00000076248 | uracil-DNA glycosylase |
Leishmania braziliensis | LbrM.18.0540 | uracil-DNA-glycosylase, putative |
Leishmania donovani | LdBPK_180480.1 | uracil-DNA-glycosylase, putative |
Leishmania infantum | LinJ.18.0480 | uracil-DNA-glycosylase, putative |
Leishmania major | LmjF.18.0480 | uracil-DNA-glycosylase, putative |
Leishmania mexicana | LmxM.18.0480 | uracil-DNA-glycosylase, putative |
Loa Loa (eye worm) | LOAG_01467 | uracil-DNA glycosylase |
Mycobacterium leprae | ML1675c | PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG) |
Mus musculus | ENSMUSG00000029591 | uracil DNA glycosylase |
Mycobacterium tuberculosis | Rv2976c | Probable uracil-DNA glycosylase Ung (UDG) |
Mycobacterium ulcerans | MUL_1980 | uracil-DNA glycosylase |
Oryza sativa | 4337373 | Os04g0673400 |
Plasmodium berghei | PBANKA_1027700 | uracil-DNA glycosylase, putative |
Plasmodium falciparum | PF3D7_1415000 | uracil-DNA glycosylase |
Plasmodium knowlesi | PKNH_1343100 | uracil-DNA glycosylase, putative |
Plasmodium vivax | PVX_085700 | uracil-DNA glycosylase, putative |
Plasmodium yoelii | PY04457 | uracil-DNA glycosylase, putative |
Saccharomyces cerevisiae | YML021C | Ung1p |
Schistosoma japonicum | Sjp_0115290 | Uracil-DNA glycosylase, putative |
Schistosoma japonicum | Sjp_0313590 | expressed protein |
Schistosoma japonicum | Sjp_0055250 | Lamin-B2, putative |
Schistosoma japonicum | Sjp_0310640 | Lamin-L(II), putative |
Schistosoma japonicum | Sjp_0113430 | ko:K03648 uracil-DNA glycosylase, putative |
Schistosoma mansoni | Smp_158920 | uracil-DNA glycosylase |
Schmidtea mediterranea | mk4.004180.00 | Uracil-DNA glycosylase |
Trypanosoma brucei gambiense | Tbg972.10.17160 | uracil-DNA glycosylase, putative |
Trypanosoma brucei | Tb927.10.13970 | uracil-DNA glycosylase, putative |
Trypanosoma congolense | TcIL3000_10_11720 | uracil-DNA glycosylase, putative |
Trypanosoma cruzi | TcCLB.511277.330 | uracil-DNA glycosylase |
Toxoplasma gondii | TGME49_307650 | uracil-DNA glycosylase |
Theileria parva | TP02_0373 | uracil-DNA glycosylase, putative |
Trichomonas vaginalis | TVAG_320720 | uracil DNA glycosylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.13970 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.13970 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.13970 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.13970 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2580 | Escherichia coli | non-essential | goodall |
TGME49_307650 | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | uracil-DNA glycosylase | Compounds | References |
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR)) | Uracil-DNA glycosylase | Compounds | References |