pI: 7.3488 |
Length (AA): 414 |
MW (Da): 44805 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 398 | 3c48 (A) | 1 | 410 | 27.00 | 0 | 1 | 1.24635 | -0.12 |
1 | 390 | 4n9w (A) | 1 | 360 | 33.00 | 0 | 1 | 1.13543 | 0.51 |
2 | 405 | 1v4v (A) | 7 | 376 | 15.00 | 0 | 1 | 1.02485 | 0.29 |
216 | 372 | 3qhp (A) | 202 | 354 | 21.00 | 0 | 1 | 0.694227 | -0.73 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127105)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G45100 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase subunit PIG-A-like protein SETH |
Babesia bovis | BBOV_III008560 | glycosyl transferase, group 1 family protein |
Brugia malayi | Bm1_42330 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein |
Candida albicans | CaO19.8117 | glycosyl-phosphatidylinositol synthesis |
Candida albicans | CaO19.487 | glycosyl-phosphatidylinositol synthesis |
Caenorhabditis elegans | CELE_D2085.6 | Protein PIGA-1 |
Cryptosporidium hominis | Chro.50057 | glycan synthetase |
Cryptosporidium hominis | Chro.40236 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein |
Cryptosporidium parvum | cgd5_3140 | LPS glycosyltransferase of possible cyanobacterial origin |
Cryptosporidium parvum | cgd4_2100 | PIG-A like N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein |
Dictyostelium discoideum | DDB_G0283965 | GlcNAc transferase |
Drosophila melanogaster | Dmel_CG6401 | CG6401 gene product from transcript CG6401-RB |
Echinococcus granulosus | EgrG_002062100 | phosphatidylinositol |
Echinococcus granulosus | EgrG_002006650 | glycosyltransferase |
Entamoeba histolytica | EHI_105870 | phosphatidylinositol N-acetylglucosaminyltransferase subunit A, putative |
Echinococcus multilocularis | EmuJ_000335800 | phosphatidylinositol |
Giardia lamblia | GL50803_113610 | GlcNAc-PI synthesis protein |
Homo sapiens | ENSG00000165195 | phosphatidylinositol glycan anchor biosynthesis, class A |
Leishmania braziliensis | LbrM.33.1940 | UDP-GlcNAc:PI a1-6 GlcNAc-transferase |
Leishmania donovani | LdBPK_331770.1 | GlcNAc-PI synthesis protein |
Leishmania infantum | LinJ.33.1770 | UDP-GlcNAc:PI a1-6 GlcNAc-transferase |
Leishmania major | LmjF.33.1670 | UDP-GlcNAc:PI a1-6 GlcNAc-transferase |
Leishmania mexicana | LmxM.32.1670 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein, putative |
Loa Loa (eye worm) | LOAG_00914 | hypothetical protein |
Mycobacterium leprae | ML1715 | POSSIBLE TRANSFERASE |
Mus musculus | ENSMUSG00000031381 | phosphatidylinositol glycan anchor biosynthesis, class A |
Mycobacterium tuberculosis | Rv3032 | Alpha (1-4) glucosyltransferase |
Mycobacterium ulcerans | MUL_1919 | transferase |
Mycobacterium ulcerans | MUL_4676 | glycosyltransferase |
Neospora caninum | NCLIV_017280 | phosphatidylinositolglycan class A protein, putative |
Plasmodium berghei | PBANKA_0516200 | phosphatidylinositol N-acetylglucosaminyltransferase subunit A, putative |
Plasmodium falciparum | PF3D7_1032400 | phosphatidylinositol N-acetylglucosaminyltransferase subunit A, putative |
Plasmodium knowlesi | PKNH_0617200 | phosphatidylinositol N-acetylglucosaminyltransferase subunit A, putative |
Plasmodium vivax | PVX_111105 | phosphatidylinositol N-acetylglucosaminyltransferase subunit A, putative |
Plasmodium yoelii | PY03143 | Arabidopsis thaliana At3g45100/T14D3_40-related |
Saccharomyces cerevisiae | YPL175W | Spt14p |
Schistosoma japonicum | Sjp_0117970 | expressed protein |
Schistosoma japonicum | Sjp_0052190 | ko:K03857 phosphatidylinositol glycan, class A, putative |
Schistosoma mansoni | Smp_046880.1 | glycosyltransferase |
Schistosoma mansoni | Smp_046880.2 | glycosyltransferase |
Schmidtea mediterranea | mk4.019512.01 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A |
Schmidtea mediterranea | mk4.012220.00 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A |
Trypanosoma brucei gambiense | Tbg.972.2.330 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein, putative |
Trypanosoma brucei | Tb927.2.1780 | GlcNAc-PI synthesis protein |
Trypanosoma brucei | Tb11.v5.0765 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein, putative |
Trypanosoma congolense | TcIL3000_2_20 | GlcNAc-PI synthesis protein |
Trypanosoma cruzi | TcCLB.510259.18 | GlcNAc-PI synthesis protein |
Trypanosoma cruzi | TcCLB.509215.16 | GlcNAc-PI synthesis protein |
Toxoplasma gondii | TGME49_241860 | N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein PigA, family GT4 protein |
Theileria parva | TP04_0759 | N-acetylglucosaminyl-phosphatidylinositol, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.1780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.1780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.1780 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.1780 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
YPL175W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_241860 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.