Detailed view for Rv3133c

Basic information

TDR Targets ID: 5865
Mycobacterium tuberculosis, TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY LUXR/UHPA-FAMILY)

Source Database / ID: Tuberculist / Rv3133c 

pI: 5.4523 | Length (AA): 218 | MW (Da): 23262 | Number of Paralogs: 1

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00072   Response_reg

Gene Ontology

Component: (mouse over links to read term descriptions)

GO:0005622   intracellular  

Function: (mouse over links to read term descriptions)

GO:0043565   sequence-specific DNA binding  
GO:0003700   transcription factor activity  
GO:0000156   two-component response regulator activity  
Metabolic Pathways

Two-component system (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: 1ZLJ   1ZLK   3C3W   3C57  

Expression

Upregulation ranking: this gene ranks in the upper 80-100% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 10
Cumulative epitope score: 11.3
Normalized epitope score: 5.2
Percentile: 70.9 (this protein belongs to the top 29.1% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10951
Number of Paralogs: 1

Ortholog group members from selected species:
Escherichia coli K12 NP_416424.1   response regulator [Escherichia coli K12]... |   OrthoMCL
Escherichia coli K12 NP_416697.1   DNA-binding response regulator in two-component regulatory s... |   OrthoMCL
Escherichia coli K12 NP_415739.1   DNA-binding response regulator in two-component regulatory s... |   OrthoMCL
Mycobacterium tuberculosis Rv0844c   POSSIBLE NITRATE/NITRITE RESPONSE TRANSCRIPTIONAL REGULATORY... |   OrthoMCL
Mycobacterium tuberculosis Rv3133c (this record).   TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBA... |   OrthoMCL

Essentiality Rv3133c has essentiality data
Gene/Ortholog: mtu3185 (OG4_10951); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu860 (OG4_10951); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco1186 (OG4_10951); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco1186 (OG4_10951); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco1186 (OG4_10951); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco1186 (OG4_10951); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco1866 (OG4_10951); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco1866 (OG4_10951); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco1866 (OG4_10951); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco1866 (OG4_10951); Phenotype: undefined; Source study: shigen
Gene/Ortholog: eco2124 (OG4_10951); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco2124 (OG4_10951); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco2124 (OG4_10951); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco2124 (OG4_10951); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition
Evidence: inferred from loss-of-function mutant phenotype (ECO:0000016)
Observed in: Mycobacterium bovis (NEWT:1765)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-28.
PubMed References: 12446625

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition
Evidence: inferred from loss-of-function mutant phenotype (ECO:0000016)
Observed in: Mycobacterium smegmatis (NEWT:1772)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-28.
PubMed References: 12591871

Affected entity: pathogenesis (GO:0009405) [+/–] show term definition

The set of specific processes that generate the ability of an organism to cause disease in another. Synonym: channel-forming toxin activity

Phenotypic quality: increased sensitivity toward (PATO:0001549) [+/–] show term definition
Evidence: inferred from animal model system (ECO:0000179)
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-28.
PubMed References: 12595424

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: normal (PATO:0000461) [+/–] show term definition
Evidence: inferred from in vitro culture assay (ECO:0000182) [+/–] show term definition
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-28.
PubMed References: 14987770

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition
Evidence: inferred from animal model system (ECO:0000179)
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-28.
PubMed References: 14987770

No validation aspects annotated for this target.

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    4 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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