Detailed view for Rv3153

Basic information

TDR Targets ID: 981430
Mycobacterium tuberculosis, Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I)
Source Database / ID:  Tuberculist 

pI: 6.8196 | Length (AA): 211 | MW (Da): 23434 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Oxidative phosphorylation (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 208 4hea (9) 3 180 46.00 0 1 1.3419 0.56
79 144 1fca (A) 6 55 42.00 0 1 0.457496 0.31
81 137 4omf (G) 220 260 54.00 0.0067 0.84 0.383942 1.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128019)

Species Accession Gene Product
Arabidopsis thaliana ArthCp078   NADH dehydrogenase 18 kDa subunit
Arabidopsis thaliana AT1G79010   NADH dehydrogenase [ubiquinone] iron-sulfur protein 8
Arabidopsis thaliana AT1G16700   Alpha-helical ferredoxin
Brugia malayi Bm1_20770   NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial precursor
Candida albicans CaO19.12222   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUIM subunit, N. crassa CI-23kd
Candida albicans CaO19.4758   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUIM subunit, N. crassa CI-23kd
Caenorhabditis elegans CELE_T20H4.5   Protein T20H4.5
Dictyostelium discoideum DDB_G0277231   NADH dehydrogenase Fe-S protein 8
Drosophila melanogaster Dmel_CG3944   NADH:ubiquinone reductase 23kD subunit precursor
Escherichia coli b2281   NADH:ubiquinone oxidoreductase, chain I
Echinococcus granulosus EgrG_000844700   NADH dehydrogenase ubiquinone iron sulfur
Echinococcus multilocularis EmuJ_000844700   NADH dehydrogenase (ubiquinone) iron sulfur
Homo sapiens ENSG00000110717   NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
Loa Loa (eye worm) LOAG_03457   NADH-ubiquinone oxidoreductase 23 kDa subunit
Mus musculus ENSMUSG00000059734   NADH dehydrogenase (ubiquinone) Fe-S protein 8
Mycobacterium tuberculosis Rv3153   Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I)
Mycobacterium ulcerans MUL_2467   NADH dehydrogenase subunit I
Oryza sativa 3131488   NADH dehydrogenase 18 kDa subunit
Oryza sativa 4334276   Os03g0774200
Schistosoma japonicum Sjp_0063950   ko:K03941 NADH dehydrogenase (ubiquinone) Fe-S protein 8, putative
Schistosoma mansoni Smp_042590.1   NADH-ubiquinone oxidoreductase
Schistosoma mansoni Smp_042590.2   NADH-ubiquinone oxidoreductase
Schmidtea mediterranea mk4.000622.16   NADH dehydrogenase
Wolbachia endosymbiont of Brugia malayi Wbm0471   NADH dehydrogenase subunit I

Essentiality

Rv3153 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T20H4.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_T20H4.5 Caenorhabditis elegans larval arrest wormbase
CELE_T20H4.5 Caenorhabditis elegans slow growth wormbase
CELE_T20H4.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3153 (Mycobacterium tuberculosis), Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I)
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