Detailed view for Rv3280

Basic information

TDR Targets ID: 5622
Mycobacterium tuberculosis, Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)
Source Database / ID:  Tuberculist 

pI: 5.0193 | Length (AA): 548 | MW (Da): 59354 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01039   Carboxyl transferase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016874   ligase activity  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 548 2a7s (A) 20 548 99.99 0 1 2.13303 -0.79

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2A7S:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2BZR:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. hasan
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_130273)

Species Accession Gene Product
Caenorhabditis elegans CELE_F52E4.1   Protein PCCB-1, isoform A
Dictyostelium discoideum DDB_G0276341   propanoyl-CoA:carbon dioxide ligase beta subunit
Echinococcus granulosus EgrG_000506900   propionyl coenzyme A carboxylase beta chain
Echinococcus multilocularis EmuJ_000506900   propionyl coenzyme A carboxylase beta chain
Homo sapiens ENSG00000114054   propionyl CoA carboxylase, beta polypeptide
Leishmania braziliensis LbrM.28.0510   propionyl-coa carboxylase beta chain, putative
Leishmania donovani LdBPK_280260.1   propionyl-coa carboxylase beta chain, putative
Leishmania infantum LinJ.28.0260   propionyl-coa carboxylase beta chain, putative
Leishmania major LmjF.28.0490   propionyl-coa carboxylase beta chain, putative
Leishmania mexicana LmxM.28.0490   propionyl-coa carboxylase beta chain, putative
Mycobacterium leprae ML0731c   Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)
Mus musculus ENSMUSG00000032527   propionyl Coenzyme A carboxylase, beta polypeptide
Mycobacterium tuberculosis Rv3280   Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)
Mycobacterium ulcerans MUL_3864   propionyl-CoA carboxylase beta chain 4 AccD4_2
Mycobacterium ulcerans MUL_2632   propionyl-CoA carboxylase beta chain 5 AccD5
Schistosoma japonicum Sjp_0021810   ko:K01966 propionyl-CoA carboxylase beta chain [EC6.4.1.3B], putative
Schistosoma mansoni Smp_163230   propionyl-CoA carboxylase beta chain mitochondrial precursor
Wolbachia endosymbiont of Brugia malayi Wbm0588   Acetyl-CoA carboxylase, carboxyltransferase component

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) inferred from in-silico analysis (ECO:0000043) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-07. References: 16261191

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3280 (Mycobacterium tuberculosis), Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)
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