Detailed view for Rv3309c

Basic information

TDR Targets ID: 980202
Mycobacterium tuberculosis, Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Source Database / ID:  Tuberculist 

pI: 4.7286 | Length (AA): 207 | MW (Da): 21866 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14681  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Pyrimidine metabolism (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 204 5e38 (A) 2 204 99.99 0 1 2.15538 -0.86
58 164 5bqp (A) 19 128 17.00 0 0.97 0.794608 -0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126624)

Species Accession Gene Product
Arabidopsis thaliana AT3G27440   uridine kinase-like 5
Arabidopsis thaliana AT1G55810   uridine kinase-like protein 3
Arabidopsis thaliana AT3G53900   uracil phosphoribosyltransferase
Arabidopsis thaliana AT5G40870   uridine kinase/uracil phosphoribosyltransferase 1
Arabidopsis thaliana AT4G26510   uridine kinase-like 4
Arabidopsis thaliana AT3G27190   uridine kinase-like 2
Brugia malayi Bm1_33225   uridine monophosphate kinase
Brugia malayi Bm1_47725   bA311P8.3
Brugia malayi Bm1_39635   Uridine kinase-like 1
Candida albicans CaO19.2640   similar to S. cerevisiae FUR1 (YHR128W) uracil phosphoribosyltransferase involved in regulation of the pyrimidine salvage pathwa
Candida albicans CaO19.10163   similar to S. cerevisiae FUR1 (YHR128W) uracil phosphoribosyltransferase involved in regulation of the pyrimidine salvage pathwa
Candida albicans CaO19.5864   likely uridine kinase similar to S. cerevisiae URK1 (YNR012W) involved in pyrimidine salvage
Candida albicans CaO19.13286   likely uridine kinase similar to S. cerevisiae URK1 (YNR012W) involved in pyrimidine salvage
Caenorhabditis elegans CELE_F19B6.1   Protein F19B6.1, isoform C
Caenorhabditis elegans CELE_C47B2.2   Protein C47B2.2
Cryptosporidium hominis Chro.80328   uridine kinase/uracil phosphoribosyltransferase
Cryptosporidium hominis Chro.10216   uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase) (UPRT)
Cryptosporidium parvum cgd1_1900   Fur1p like uracil phosphoribosyltransferase
Cryptosporidium parvum cgd8_2810   uridine kinase like P-loop NTpase
Dictyostelium discoideum DDB_G0269034   uridine kinase
Dictyostelium discoideum DDB_G0267560   uracil phosphoribosyltransferase
Dictyostelium discoideum DDB_G0274559   uridine kinase
Drosophila melanogaster Dmel_CG4798   lethal (2) k01209
Drosophila melanogaster Dmel_CG6364   CG6364 gene product from transcript CG6364-RD
Drosophila melanogaster Dmel_CG5537   CG5537 gene product from transcript CG5537-RC
Escherichia coli b2498   uracil phosphoribosyltransferase
Escherichia coli b2066   uridine/cytidine kinase
Echinococcus granulosus EgrG_000751300   uridine cytidine kinase 2
Echinococcus granulosus EgrG_000188900   uridine cytidine kinase 1 1
Echinococcus granulosus EgrG_000167100   uracil phosphoribosyltransferase
Entamoeba histolytica EHI_196580   phosphoribulokinase /uridine kinase family protein
Entamoeba histolytica EHI_193300   phosphoribulokinase/uridine kinase family protein
Entamoeba histolytica EHI_051730   phosphoribulokinase/uridine kinase family protein
Echinococcus multilocularis EmuJ_000188900   uridine cytidine kinase 1 1
Echinococcus multilocularis EmuJ_000167100   uracil phosphoribosyltransferase
Echinococcus multilocularis EmuJ_000751300   uridine cytidine kinase 2
Giardia lamblia GL50803_6563   Uracil phosphoribosyltransferase
Homo sapiens ENSG00000130717   uridine-cytidine kinase 1
Homo sapiens ENSG00000198276   uridine-cytidine kinase 1-like 1
Homo sapiens 7371   uridine-cytidine kinase 2
Homo sapiens ENSG00000094841   uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
Leishmania braziliensis LbrM.20.1010   uracil phosphoribosyltransferase, putative
Leishmania braziliensis LbrM.31.2810   uridine kinase-like protein
Leishmania braziliensis LbrM.31.2760   uridine kinase-like protein
Leishmania donovani LdBPK_341110.1   uracil phosphoribosyltransferase, putative
Leishmania donovani LdBPK_312560.1   uridine kinase-like protein
Leishmania infantum LinJ.34.1110   uracil phosphoribosyltransferase, putative
Leishmania infantum LinJ.31.2560   uridine kinase-like protein
Leishmania major LmjF.34.1040   uracil phosphoribosyltransferase, putative
Leishmania major LmjF.31.2470   uridine kinase-like protein
Leishmania mexicana LmxM.33.1040   uracil phosphoribosyltransferase, putative
Loa Loa (eye worm) LOAG_09992   hypothetical protein
Loa Loa (eye worm) LOAG_09652   hypothetical protein
Loa Loa (eye worm) LOAG_05817   hypothetical protein
Loa Loa (eye worm) LOAG_13791   hypothetical protein
Mus musculus ENSMUSG00000089917   uridine-cytidine kinase 1-like 1
Mus musculus ENSMUSG00000002550   uridine-cytidine kinase 1
Mus musculus 331487   uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
Mus musculus ensembl-mmu:ENSMUSG00000026558   uridine-cytidine kinase 2
Mycobacterium tuberculosis Rv3309c   Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Mycobacterium ulcerans MUL_2675   uracil phosphoribosyltransferase
Neospora caninum NCLIV_056020   hypothetical protein
Oryza sativa 4338981   Os05g0455700
Oryza sativa 4328991   Os02g0273000
Oryza sativa 4350243   Os11g0265000
Oryza sativa 4346121   Os08g0530000
Oryza sativa 4347509   Os09g0505800
Onchocerca volvulus OVOC1035   Uracil phosphoribosyltransferase homolog
Saccharomyces cerevisiae YNR012W   uridine kinase URK1
Saccharomyces cerevisiae YHR128W   uracil phosphoribosyltransferase
Schistosoma japonicum Sjp_0059830   Uridine-cytidine kinase 2, putative
Schistosoma japonicum Sjp_0212650   ko:K00761 uracil phosphoribosyltransferase [EC2.4.2.9], putative
Schistosoma mansoni Smp_062260.1   uridine cytidine kinase I
Schistosoma mansoni Smp_095810   uracil phosphoribosyltransferase
Schistosoma mansoni Smp_178910   uridine cytidine kinase I
Schistosoma mansoni Smp_062260.3   uridine cytidine kinase I
Schmidtea mediterranea mk4.000485.12   Uridine-cytidine kinase-like 1
Schmidtea mediterranea mk4.025457.00   Uridine kinase
Schmidtea mediterranea mk4.034237.02  
Schmidtea mediterranea mk4.018469.00   Probable uridine-cytidine kinase
Schmidtea mediterranea mk4.000365.11   Uracil phosphoribosyltransferase homolog
Schmidtea mediterranea mk4.018513.00   Probable uridine-cytidine kinase
Trypanosoma brucei gambiense Tbg972.4.3330   uracil phosphoribosyltransferase, putative
Trypanosoma brucei Tb927.4.3320   uracil phosphoribosyltransferase, putative
Trypanosoma congolense TcIL3000_4_3010   uracil phosphoribosyltransferase, putative
Trypanosoma cruzi TcCLB.507739.40   uracil phosphoribosyltransferase, putative
Trypanosoma cruzi TcCLB.506435.410   uracil phosphoribosyltransferase, putative
Toxoplasma gondii TGME49_312480   uracil phosphoribosyltransferase FUR1, putative
Treponema pallidum TP0448   uracil phosphoribosyltransferase

Essentiality

Rv3309c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.3320 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.3320 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.3320 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.3320 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b2066 Escherichia coli non-essential goodall
b2498 Escherichia coli non-essential goodall
YHR128W Saccharomyces cerevisiae inviable yeastgenome
TGME49_312480 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Escherichia coli uracil phosphoribosyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3309c (Mycobacterium tuberculosis), Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
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