pI: 7.4017 |
Length (AA): 263 |
MW (Da): 29335 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
21 | 263 | 2h88 (B) | 9 | 246 | 28.00 | 0 | 1 | 1.21665 | 0.4 |
24 | 260 | 1kf6 (B) | 6 | 232 | 38.00 | 0 | 1 | 1.36024 | -0.46 |
28 | 260 | 2wdq (B) | 7 | 234 | 46.00 | 0 | 1 | 1.37503 | -0.15 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_126893)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G40650 | succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2 |
Arabidopsis thaliana | AT5G65165 | succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3 |
Arabidopsis thaliana | AT3G27380 | succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1 |
Babesia bovis | BBOV_IV005280 | succinate dehydrogenase iron-sulfur subunit, putative |
Brugia malayi | Bm1_17690 | succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial |
Candida albicans | CaO19.8251 | iron-sulfur subunit of succinate dehydrogenase |
Candida albicans | CaO19.637 | iron-sulfur subunit of succinate dehydrogenase |
Caenorhabditis elegans | CELE_F42A8.2 | Protein SDHB-1 |
Chlamydia trachomatis | CT_591 | succinate dehydrogenase iron sulfur subunit |
Dictyostelium discoideum | DDB_G0270120 | complex II, iron-sulfur protein subunit |
Drosophila melanogaster | Dmel_CG7349 | CG7349 gene product from transcript CG7349-RC |
Drosophila melanogaster | Dmel_CG3283 | Succinate dehydrogenase B |
Escherichia coli | b4153 | fumarate reductase (anaerobic), Fe-S subunit |
Escherichia coli | b0724 | succinate dehydrogenase, FeS subunit |
Echinococcus granulosus | EgrG_000416100 | succinate dehydrogenase (ubiquinone) iron sulfur |
Echinococcus granulosus | EgrG_000416200 | succinate dehydrogenase ubiquinone iron sulfur |
Echinococcus multilocularis | EmuJ_000416100 | succinate dehydrogenase iron sulfur protein |
Echinococcus multilocularis | EmuJ_000416200 | succinate dehydrogenase (ubiquinone) iron sulfur |
Echinococcus multilocularis | EmuJ_000416000 | succinate dehydrogenase (ubiquinone) iron sulfur |
Homo sapiens | ENSG00000117118 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
Leishmania braziliensis | LbrM.15.1030 | succinate dehydrogenase, putative |
Leishmania braziliensis | LbrM.23.1530 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_151050.1 | succinate dehydrogenase, putative |
Leishmania donovani | LdBPK_231680.1 | succinate dehydrogenase and fumarate reductase iron-sulfur protein, putative |
Leishmania infantum | LinJ.23.1680 | hypothetical protein, conserved |
Leishmania infantum | LinJ.15.1050 | succinate dehydrogenase, putative |
Leishmania major | LmjF.23.1410 | hypothetical protein, conserved |
Leishmania major | LmjF.15.0990 | succinate dehydrogenase, putative |
Leishmania mexicana | LmxM.15.0990 | succinate dehydrogenase, putative |
Leishmania mexicana | LmxM.23.1410 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_10155 | succinate dehydrogenase iron-sulfur protein |
Mycobacterium leprae | ML0696c | Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHY |
Mus musculus | ENSMUSG00000009863 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
Mycobacterium tuberculosis | Rv3319 | Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate deh |
Mycobacterium tuberculosis | Rv1553 | Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) |
Mycobacterium ulcerans | MUL_1370 | succinate dehydrogenase iron-sulfur subunit |
Neospora caninum | NCLIV_052230 | Succinate dehydrogenase iron-sulfur subunit, related |
Oryza sativa | 4346890 | Os09g0370300 |
Oryza sativa | 4344541 | Os08g0120000 |
Plasmodium berghei | PBANKA_1428800 | iron-sulfur subunit of succinate dehydrogenase, putative |
Plasmodium falciparum | PF3D7_1212800 | iron-sulfur subunit of succinate dehydrogenase |
Plasmodium knowlesi | PKNH_1432200 | iron-sulfur subunit of succinate dehydrogenase, putative |
Plasmodium vivax | PVX_123345 | iron-sulfur subunit of succinate dehydrogenase, putative |
Plasmodium yoelii | PY04921 | succinate dehydrogenase iron-sulfur subunit |
Saccharomyces cerevisiae | YLL041C | succinate dehydrogenase iron-sulfur protein subunit SDH2 |
Schistosoma japonicum | Sjp_0062650 | ko:K00235 succinate dehydrogenase (ubiquinone) iron-sulfur protein precursor, putative |
Schistosoma mansoni | Smp_089640.2 | succinate dehydrogenase iron-sulfur protein |
Schistosoma mansoni | Smp_089640.3 | succinate dehydrogenase iron-sulfur protein |
Schmidtea mediterranea | mk4.000382.04 | Putative succinate dehydrogenase iron-sulfur protein |
Trypanosoma brucei gambiense | Tbg972.8.3140 | electron transfer protein, putative |
Trypanosoma brucei gambiense | Tbg972.9.3110 | succinate dehydrogenase, putative |
Trypanosoma brucei | Tb927.8.3380 | succinate dehydrogenase iron-sulfur subunit |
Trypanosoma brucei | Tb927.9.5960 | succinate dehydrogenase iron-sulfur subunit, putative |
Trypanosoma congolense | TcIL3000_8_3420 | electron transfer protein, putative |
Trypanosoma congolense | TcIL3000_9_2010 | succinate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.505843.24 | succinate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.504949.30 | succinate dehydrogenase iron-sulfur subunit |
Trypanosoma cruzi | TcCLB.509769.60 | succinate dehydrogenase iron-sulfur subunit |
Toxoplasma gondii | TGME49_215280 | succinate dehydrogenase [ubiquinone] iron-sulfur protein |
Theileria parva | TP01_0210 | succinate dehydrogenase iron-sulfur subunit, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0600 | succinate dehydrogenase iron-sulfur subunit |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1581 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3379 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb09.160.4380 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.4380 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.4380 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.4380 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.8.3380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3380 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.3380 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0724 | Escherichia coli | non-essential | goodall |
b4153 | Escherichia coli | non-essential | goodall |
CELE_F42A8.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F42A8.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F42A8.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F42A8.2 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1428800 | Plasmodium berghei | Dispensable | plasmo |
TGME49_215280 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | iron-sulfur subunit of succinate dehydrogenase | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
Rv3319 | purified protein | BRENDA | A protein with this EC number or name or sequence has been purified from Mycobacterium phlei ( 1 ) |
69 literature references were collected for this gene.