Detailed view for Rv3331

Basic information

TDR Targets ID: 980262
Mycobacterium tuberculosis, Probable sugar-transport integral membrane protein SugI
Source Database / ID:  Tuberculist 

pI: 10.4263 | Length (AA): 502 | MW (Da): 53011 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 12

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 486 5c65 (A) 5 466 25.00 0 1 1.15909 -0.28
53 475 4lds (A) 7 427 31.00 0 1 1.21473 0.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126683)

Species Accession Gene Product
Arabidopsis thaliana AT2G43330   inositol transporter 1
Arabidopsis thaliana AT2G20780   putative polyol transporter 4
Arabidopsis thaliana AT1G30220   putative inositol transporter 2
Arabidopsis thaliana AT1G19450   sugar transporter ERD6-like 4
Arabidopsis thaliana AT1G75220   sugar transporter ERD6-like 6
Arabidopsis thaliana AT4G16480   inositol transporter 4
Arabidopsis thaliana AT2G35740   putative inositol transporter 3
Babesia bovis BBOV_IV003180   hexose transporter
Brugia malayi Bm1_37035   Sugar transporter family protein
Candida albicans CaO19.3526   potential sugar transporter similar to S. cerevisiae ITR2 (YOL103W) myo-inositol transporter
Candida albicans CaO19.11009   potential sugar transporter similar to S. cerevisiae ITR2 (YOL103W) myo-inositol transporter
Caenorhabditis elegans CELE_M01F1.5   Protein HMIT-1.3
Caenorhabditis elegans CELE_Y51A2D.5   Protein HMIT-1.2
Caenorhabditis elegans CELE_Y51A2D.4   Protein HMIT-1.1
Dictyostelium discoideum DDB_G0278261   solute carrier family 2 member protein
Drosophila melanogaster Dmel_CG30035   Trehalose transporter 1-1
Drosophila melanogaster Dmel_CG8234   Trehalose transporter 1-2
Escherichia coli b2943   D-galactose transporter
Escherichia coli b2841   arabinose transporter
Echinococcus granulosus EgrG_000904700   Sugar transporter ERD6 protein
Echinococcus multilocularis EmuJ_000904700   Sugar transporter ERD6 protein
Homo sapiens ENSG00000136856   solute carrier family 2 (facilitated glucose transporter), member 8
Homo sapiens ENSG00000151229   solute carrier family 2 (facilitated glucose transporter), member 13
Leishmania braziliensis LbrM.24.0690   myo-inositol/proton symporter (MIT)
Leishmania donovani LdBPK_240690.1   myo-inositol/proton symporter (MIT)
Leishmania infantum LinJ.24.0690   myo-inositol/proton symporter (MIT)
Leishmania major LmjF.24.0680   myo-inositol/proton symporter (MIT)
Leishmania mexicana LmxM.24.0680   sugar transporter, putative
Loa Loa (eye worm) LOAG_14278   hypothetical protein
Loa Loa (eye worm) LOAG_02529   hypothetical protein
Mus musculus ENSMUSG00000036298   solute carrier family 2 (facilitated glucose transporter), member 13
Mus musculus ENSMUSG00000026791   solute carrier family 2, (facilitated glucose transporter), member 8
Mycobacterium tuberculosis Rv3331   Probable sugar-transport integral membrane protein SugI
Mycobacterium ulcerans MUL_1444   sugar-transport integral membrane protein SugI
Neospora caninum NCLIV_034820   Sugar transporter, MFS superfamily, related
Oryza sativa 4337417   Os04g0678900
Oryza sativa 9271317   Os05g0567700
Oryza sativa 4342413   Os07g0151200
Oryza sativa 4337418   Os04g0679000
Oryza sativa 4336377   Os04g0511400
Oryza sativa 4336250   Os04g0491700
Oryza sativa 4336476   Os04g0529800
Oryza sativa 4339710   Os05g0579000
Oryza sativa 4339644   Os05g0567800
Onchocerca volvulus OVOC4466  
Onchocerca volvulus OVOC2009  
Saccharomyces cerevisiae YOL103W   myo-inositol transporter ITR2
Saccharomyces cerevisiae YDR497C   myo-inositol transporter ITR1
Schistosoma japonicum Sjp_0040050   ko:K08150 MFS transporter, SP family, solute carrier family 2 (facilitated, putative
Schmidtea mediterranea mk4.001872.01  
Schmidtea mediterranea mk4.004028.03  
Schmidtea mediterranea mk4.006848.00  
Schmidtea mediterranea mk4.020528.00   Proton myo-inositol cotransporter
Schmidtea mediterranea mk4.006848.01   Proton myo-inositol cotransporter
Schmidtea mediterranea mk4.007966.01   Proton myo-inositol cotransporter
Schmidtea mediterranea mk4.014801.02   Proton myo-inositol cotransporter
Schmidtea mediterranea mk4.010400.02  
Schmidtea mediterranea mk4.063386.02  
Schmidtea mediterranea mk4.012111.00  
Trypanosoma brucei gambiense Tbg972.11.6030   sugar transporter, putative
Trypanosoma brucei Tb927.11.5350   myo-inositol/proton symporter (MIT)
Trypanosoma congolense TcIL3000.11.5590   myo-inositol/proton symporter (MIT)
Trypanosoma cruzi TcCLB.505183.130   sugar transporter, putative
Toxoplasma gondii TGME49_272500   sugar transporter ST2
Toxoplasma gondii TGME49_257120   sugar transporter ST1
Trichomonas vaginalis TVAG_515180   conserved hypothetical protein
Trichomonas vaginalis TVAG_416910   sugar transporter, putative
Trichomonas vaginalis TVAG_449110   sugar transporter, putative
Trichomonas vaginalis TVAG_477750   sugar transporter, putative
Trichomonas vaginalis TVAG_191710   conserved hypothetical protein
Trichomonas vaginalis TVAG_354270   sugar transporter, putative
Trichomonas vaginalis TVAG_191720   sugar transporter, putative
Trichomonas vaginalis TVAG_152410   sugar transporter, putative
Trichomonas vaginalis TVAG_411900   sugar transporter, putative
Trichomonas vaginalis TVAG_191700   sugar transporter, putative
Trichomonas vaginalis TVAG_125830   sugar transporter, putative
Trichomonas vaginalis TVAG_247530   sugar transporter, putative
Trichomonas vaginalis TVAG_120560   sugar transporter, putative
Trichomonas vaginalis TVAG_490090   sugar transporter, putative
Trichomonas vaginalis TVAG_427060   sugar transporter, putative
Trichomonas vaginalis TVAG_391300   sugar transporter, putative
Trichomonas vaginalis TVAG_080800   conserved hypothetical protein
Trichomonas vaginalis TVAG_402410   sugar transporter, putative
Trichomonas vaginalis TVAG_342100   sugar transporter, putative
Trichomonas vaginalis TVAG_378130   sugar transporter, putative
Trichomonas vaginalis TVAG_453220   myo-inositol transporter, putative
Trichomonas vaginalis TVAG_393480   sugar transporter, putative
Trichomonas vaginalis TVAG_360160   sugar transporter, putative
Trichomonas vaginalis TVAG_452240   sugar transporter, putative
Trichomonas vaginalis TVAG_345280   sugar transporter, putative
Trichomonas vaginalis TVAG_214810   sugar transporter, putative
Trichomonas vaginalis TVAG_102710   sugar transporter, putative
Trichomonas vaginalis TVAG_014120   glucose transporter, putative
Trichomonas vaginalis TVAG_216150   sugar transporter, putative
Trichomonas vaginalis TVAG_515190   sugar transporter, putative
Trichomonas vaginalis TVAG_565650   sugar transporter, putative
Trichomonas vaginalis TVAG_117680   sugar transporter, putative
Trichomonas vaginalis TVAG_244100   sugar transporter, putative
Trichomonas vaginalis TVAG_415030   sugar transporter, putative
Trichomonas vaginalis TVAG_015340   sugar transporter, putative
Trichomonas vaginalis TVAG_247410   conserved hypothetical protein
Trichomonas vaginalis TVAG_354420   sugar transporter, putative
Trichomonas vaginalis TVAG_038270   sugar transport protein, putative
Trichomonas vaginalis TVAG_014130   hypothetical protein
Trichomonas vaginalis TVAG_495690   conserved hypothetical protein

Essentiality

Rv3331 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3020 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3020 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3020 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.02.3020 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b2841 Escherichia coli non-essential goodall
b2943 Escherichia coli non-essential goodall
TGME49_272500 Toxoplasma gondii Probably non-essential sidik
TGME49_257120 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Solute carrier family 2, facilitated glucose transporter member 1 492 aa 27.7% 491 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3331 (Mycobacterium tuberculosis), Probable sugar-transport integral membrane protein SugI
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