Detailed view for Rv3442c

Basic information

TDR Targets ID: 980980
Mycobacterium tuberculosis, 30S ribosomal protein S9 RpsI
Source Database / ID:  Tuberculist 

pI: 11.3233 | Length (AA): 151 | MW (Da): 16436 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00380  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 151 2vqe (I) 2 128 52.00 0 1 1.50916 -0.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127478)

Species Accession Gene Product
Arabidopsis thaliana AT3G49080   ribosomal protein S5 domain 2-like superfamily protein
Arabidopsis thaliana AT1G74970   30S ribosomal protein S9
Babesia bovis BBOV_III006150   ribosomal protein S9, putative
Brugia malayi Bm1_44960   ribosomal protein S9 containing protein
Candida albicans CaO19.12695   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPS9 (YBR146W) small subunit protein S9
Candida albicans CaO19.5230   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPS9 (YBR146W) small subunit protein S9
Caenorhabditis elegans CELE_F09G8.3   Protein MRPS-9
Chlamydia trachomatis CT_126   30S ribosomal protein S9
Dictyostelium discoideum DDB_G0292882   hypothetical protein
Drosophila melanogaster Dmel_CG2957   mitochondrial ribosomal protein S9
Escherichia coli b3230   30S ribosomal subunit protein S9
Echinococcus granulosus EgrG_000644900   28S ribosomal protein S9, mitochondrial
Echinococcus multilocularis EmuJ_000644900   28S ribosomal protein S9, mitochondrial
Homo sapiens ENSG00000135972   mitochondrial ribosomal protein S9
Loa Loa (eye worm) LOAG_07314   ribosomal protein S9 containing protein
Mycobacterium leprae ML0365   Probable 30S ribosomal protein S9 RpsI
Mus musculus ENSMUSG00000060679   mitochondrial ribosomal protein S9
Mycobacterium tuberculosis Rv3442c   30S ribosomal protein S9 RpsI
Mycobacterium ulcerans MUL_0865   30S ribosomal protein S9
Neospora caninum NCLIV_061530   30S ribosomal protein S9, related
Oryza sativa 4334247   Os03g0769100
Oryza sativa 4344162   Os07g0658200
Plasmodium berghei PBANKA_1029300   30S ribosomal protein S9, putative
Plasmodium falciparum PF3D7_1413400   30S ribosomal protein S9, putative
Plasmodium knowlesi PKNH_1344900   30S ribosomal protein S9, putative
Plasmodium vivax PVX_085780   30S ribosomal protein S9, putative
Plasmodium yoelii PY07168   ribosomal protein S9, putative
Saccharomyces cerevisiae YBR146W   mitochondrial 37S ribosomal protein MRPS9
Schistosoma japonicum Sjp_0302740   ko:K02996 small subunit ribosomal protein S9, putative
Schistosoma mansoni Smp_164780   hypothetical protein
Schistosoma mansoni Smp_164790   mitochondrial ribosomal protein S9
Schmidtea mediterranea mk4.001645.02   Probable 40S ribosomal protein S9, mitochondrial
Toxoplasma gondii TGME49_218850   ribosomal protein RPS9
Treponema pallidum TP1024   30S ribosomal protein S9
Theileria parva TP02_0347   40S ribosomal protein S9, putative
Wolbachia endosymbiont of Brugia malayi Wbm0573   30S ribosomal protein S9

Essentiality

Rv3442c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3230 Escherichia coli essential goodall
CELE_F09G8.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F09G8.3 Caenorhabditis elegans larval arrest wormbase
CELE_F09G8.3 Caenorhabditis elegans slow growth wormbase
CELE_F09G8.3 Caenorhabditis elegans sterile wormbase
TGME49_218850 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3442c (Mycobacterium tuberculosis), 30S ribosomal protein S9 RpsI
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