Detailed view for Rv3459c

Basic information

TDR Targets ID: 7082
Mycobacterium tuberculosis, 30S ribosomal protein S11 RpsK
Source Database / ID:  Tuberculist 

pI: 12.2202 | Length (AA): 139 | MW (Da): 14785 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00411   Ribosomal protein S11

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 138 2vqe (K) 11 126 60.00 0 1 1.64543 -1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_126681)

Species Accession Gene Product
Arabidopsis thaliana AT3G52580   40S ribosomal protein S14-3
Arabidopsis thaliana AT2G36160   40S ribosomal protein S14-1
Arabidopsis thaliana AT3G11510   40S ribosomal protein S14-2
Arabidopsis thaliana ArthCp056   30S ribosomal protein S11
Babesia bovis BBOV_II003160   40S ribosomal subunit protein S14, putative
Brugia malayi Bm1_16715   40S ribosomal protein S14
Brugia malayi Bm1_30295   30S ribosomal protein S11
Brugia malayi Bm1_50660   ribosomal protein S11 containing protein
Caenorhabditis elegans CELE_F37C12.9   Protein RPS-14
Caenorhabditis elegans CELE_W04D2.5   Protein MRPS-11
Cryptosporidium hominis Chro.70025   40S ribosomal protein S14
Cryptosporidium parvum cgd7_130   40S ribosomal protein S14
Chlamydia trachomatis CT_508   30S ribosomal protein S11
Dictyostelium discoideum DDB_G0291526   40S ribosomal protein S14
Drosophila melanogaster Dmel_CG1524   Ribosomal protein S14a
Drosophila melanogaster Dmel_CG5184   mitochondrial ribosomal protein S11
Drosophila melanogaster Dmel_CG1527   Ribosomal protein S14b
Escherichia coli b3297   30S ribosomal subunit protein S11
Echinococcus granulosus EgrG_001194000   ribosomal protein s14
Echinococcus granulosus EgrG_000714200   28S ribosomal protein S11 mitochondrial
Entamoeba histolytica EHI_074090   40S ribosomal protein S14, putative
Entamoeba histolytica EHI_012360   ribosomal protein S14, putative
Echinococcus multilocularis EmuJ_000714200   28S ribosomal protein S11, mitochondrial
Echinococcus multilocularis EmuJ_001194000   ribosomal protein s14
Giardia lamblia GL50803_7878   Ribosomal protein S14
Homo sapiens 64963   mitochondrial ribosomal protein S11
Homo sapiens ENSG00000164587   ribosomal protein S14
Leishmania braziliensis LbrM.30.3620   40S ribosomal protein S14
Leishmania braziliensis LbrM.28.1030   40S ribosomal protein S14
Leishmania donovani LdBPK_281050.1   40S ribosomal protein S14
Leishmania donovani LdBPK_303650.1   40S ribosomal protein S14
Leishmania infantum LinJ.28.1050   40S ribosomal protein S14
Leishmania infantum LinJ.30.3650   40S ribosomal protein S14
Leishmania major LmjF.28.0960   40S ribosomal protein S14
Leishmania mexicana LmxM.29.3590   40S ribosomal protein S14
Leishmania mexicana LmxM.28.0960   40S ribosomal protein S14
Loa Loa (eye worm) LOAG_11842   ribosomal protein S14
Loa Loa (eye worm) LOAG_07698   ribosomal protein S11 containing protein
Mycobacterium leprae ML1959c   PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK
Mus musculus ENSMUSG00000024608   ribosomal protein S14
Mus musculus ENSMUSG00000030611   mitochondrial ribosomal protein S11
Mycobacterium tuberculosis Rv3459c   30S ribosomal protein S11 RpsK
Mycobacterium ulcerans MUL_0846   30S ribosomal protein S11
Neospora caninum NCLIV_024250   hypothetical protein
Oryza sativa 4328392   Os02g0162500
Oryza sativa 4329563   Os02g0534800
Oryza sativa 4335791   Os04g0413600
Oryza sativa 3131435   30S ribosomal protein S11
Plasmodium berghei PBANKA_1231000   40S ribosomal protein S11, putative
Plasmodium falciparum PF3D7_0516200   40S ribosomal protein S11
Plasmodium knowlesi PKNH_1017100   40S ribosomal protein S11, putative
Plasmodium vivax PVX_080440   40S ribosomal protein S11, putative
Plasmodium yoelii PY01636   ribosomal protein S11, putative
Saccharomyces cerevisiae YJL191W   ribosomal 40S subunit protein S14B
Saccharomyces cerevisiae YCR031C   ribosomal 40S subunit protein S14A
Schistosoma japonicum Sjp_0019470   ko:K02955 small subunit ribosomal protein S14e, putative
Schistosoma japonicum Sjp_0313520   40S ribosomal protein S14, putative
Schistosoma japonicum Sjp_0033470   ko:K02948 small subunit ribosomal protein S11, putative
Schistosoma mansoni Smp_013410   ribosomal protein S11
Schistosoma mansoni Smp_129420   28S ribosomal protein S11
Schistosoma mansoni Smp_053830   40S ribosomal protein S14
Schmidtea mediterranea mk4.002964.03   40S ribosomal protein S14
Schmidtea mediterranea mk4.000983.01   40S ribosomal protein S14
Schmidtea mediterranea mk4.002632.00  
Trypanosoma brucei gambiense Tbg972.6.4780   40S ribosomal protein S14, putative
Trypanosoma brucei Tb11.0290   chrXI additional, unordered contigs
Trypanosoma brucei Tb11.0390   chrXI additional, unordered contigs
Trypanosoma brucei Tb927.6.4980   40S ribosomal protein S14
Trypanosoma brucei Tb927.11.7705   ribosomal protein S11, putative
Trypanosoma congolense TcIL3000_6_4410   40S ribosomal protein S14, putative
Trypanosoma cruzi TcCLB.506945.230   40S ribosomal protein S14
Trypanosoma cruzi TcCLB.508823.50   40S ribosomal protein S14, putative
Trypanosoma cruzi TcCLB.409117.20   40S ribosomal protein S14, putative
Toxoplasma gondii TGME49_263700   ribosomal protein RPS14
Treponema pallidum TP0211   30S ribosomal protein S11
Theileria parva TP04_0277   40S ribosomal protein S14, putative
Trichomonas vaginalis TVAG_464120   30S ribosomal protein S11, putative
Trichomonas vaginalis TVAG_117480   30S ribosomal protein S11, putative
Trichomonas vaginalis TVAG_342830   40S ribosomal protein S14/30S ribosomal protein S11, putative
Trichomonas vaginalis TVAG_152720   40S ribosomal protein S14, putative
Trichomonas vaginalis TVAG_299380   30S ribosomal protein S11, putative
Wolbachia endosymbiont of Brugia malayi Wbm0319   30S ribosomal protein S11

Essentiality

Rv3459c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu3520 this record Mycobacterium tuberculosis essential nmpdr
Tb927.6.4980 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.6.4980 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4980 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.4980 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3297 Escherichia coli essential goodall
CELE_F37C12.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_F37C12.9 Caenorhabditis elegans larval arrest wormbase
CELE_F37C12.9 Caenorhabditis elegans slow growth wormbase
CELE_F37C12.9 Caenorhabditis elegans sterile wormbase
CELE_W04D2.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_W04D2.5 Caenorhabditis elegans slow growth wormbase
PBANKA_1231000 Plasmodium berghei Essential plasmo
TGME49_263700 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv3459c (Mycobacterium tuberculosis), 30S ribosomal protein S11 RpsK
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