pI: 7.0523 |
Length (AA): 202 |
MW (Da): 22395 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 201 | 4du6 (A) | 22 | 218 | 38.00 | 0 | 1 | 1.4554 | -0.23 |
15 | 199 | 4uqf (A) | 3 | 186 | 57.00 | 0 | 1 | 1.65114 | -0.73 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Dormant phase. | murphy |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | hasan |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127507)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G07270 | GTP cyclohydrolase I |
Brugia malayi | Bm1_50975 | GTP cyclohydrolase I |
Candida albicans | CaO19.11439 | GTP-cyclohydrolase I |
Candida albicans | CaO19.3957 | GTP-cyclohydrolase I |
Caenorhabditis elegans | CELE_F32G8.6 | Protein CAT-4 |
Dictyostelium discoideum | DDB_G0288481 | GTP cyclohydrolase I |
Drosophila melanogaster | Dmel_CG9441 | Punch |
Escherichia coli | b2153 | GTP cyclohydrolase I |
Echinococcus granulosus | EgrG_001065800 | GTP cyclohydrolase I |
Echinococcus multilocularis | EmuJ_001065800 | GTP cyclohydrolase I |
Homo sapiens | ENSG00000131979 | GTP cyclohydrolase 1 |
Loa Loa (eye worm) | LOAG_01526 | GTP cyclohydrolase I |
Mycobacterium leprae | ML0223 | Probable GTP cyclohydrolase I FolE (GTP-CH-I) |
Mus musculus | ENSMUSG00000037580 | GTP cyclohydrolase 1 |
Mycobacterium tuberculosis | Rv3609c | GTP cyclohydrolase I FolE (GTP-ch-I) |
Mycobacterium ulcerans | MUL_2233 | GTP cyclohydrolase I FolE |
Mycobacterium ulcerans | MUL_4191 | GTP cyclohydrolase I |
Neospora caninum | NCLIV_008130 | GTP cyclohydrolase (EC 3.5.4.16), related |
Oryza sativa | 4337297 | Os04g0662700 |
Plasmodium berghei | PBANKA_1438900 | GTP cyclohydrolase I, putative |
Plasmodium falciparum | PF3D7_1224000 | GTP cyclohydrolase I |
Plasmodium knowlesi | PKNH_1443200 | GTP cyclohydrolase I |
Plasmodium vivax | PVX_123830 | GTP cyclohydrolase I, putative |
Plasmodium yoelii | PY03300 | GTP cyclohydrolase I, putative |
Saccharomyces cerevisiae | YGR267C | GTP cyclohydrolase I |
Schistosoma mansoni | Smp_026920 | GTP cyclohydrolase I |
Schmidtea mediterranea | mk4.002948.04 | GTP cyclohydrolase 1 |
Toxoplasma gondii | TGME49_253780 | GTP cyclohydrolase I, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3671 this record | Mycobacterium tuberculosis | essential | nmpdr |
b2153 | Escherichia coli | essential | goodall |
YGR267C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1438900 | Plasmodium berghei | Dispensable | plasmo |
TGME49_253780 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.