Detailed view for Rv3634c

Basic information

TDR Targets ID: 981068
Mycobacterium tuberculosis, UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridin
Source Database / ID:  Tuberculist 

pI: 6.1356 | Length (AA): 314 | MW (Da): 33550 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 310 4zrm (A) 1 306 46.00 0 1 1.61736 -1
1 314 1gy8 (A) 1 378 31.00 0 1 1.3001 -0.5
1 309 2p5y (A) 1 308 45.00 0 1 1.56568 -0.88

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127492)

Species Accession Gene Product
Arabidopsis thaliana AT2G28760   UDP-XYL synthase 6
Arabidopsis thaliana AT3G53520   UDP-glucuronic acid decarboxylase 1
Arabidopsis thaliana AT5G59290   UDP-glucuronic acid decarboxylase 3
Arabidopsis thaliana AT2G47650   UDP-xylose synthase 4
Arabidopsis thaliana AT3G46440   UDP-XYL synthase 5
Arabidopsis thaliana AT3G62830   UDP-glucuronic acid decarboxylase
Brugia malayi Bm1_49695   UDP-glucuronic acid decarboxylase
Caenorhabditis elegans CELE_D2096.4   Protein SQV-1
Cryptosporidium hominis Chro.20206   dTDP-glucose 4-6-dehydratase-like protein
Cryptosporidium parvum cgd2_1900   dTDP-glucose 4-6-dehydratase-like protein, putative
Drosophila melanogaster Dmel_CG7979   CG7979 gene product from transcript CG7979-RA
Echinococcus granulosus EgrG_000979800   UDP glucuronic acid decarboxylase 1
Echinococcus multilocularis EmuJ_000979800   UDP glucuronic acid decarboxylase 1
Homo sapiens ENSG00000115652   UDP-glucuronate decarboxylase 1
Loa Loa (eye worm) LOAG_00123   UDP-glucuronic acid decarboxylase
Mycobacterium leprae ML0204   Probable UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase
Mus musculus 67883   UDP-glucuronate decarboxylase 1
Mycobacterium tuberculosis Rv3784   Possible dTDP-glucose 4,6-dehydratase
Mycobacterium tuberculosis Rv3634c   UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridin
Mycobacterium ulcerans MUL_4210   UDP-glucose 4-epimerase GalE1
Oryza sativa 4327295   Os01g0315800
Oryza sativa 4327367   Os01g0837300
Oryza sativa 4332424   Os03g0278000
Oryza sativa 4332441   Os03g0280800
Oryza sativa 4344260   Os07g0674100
Oryza sativa 4338546   Os05g0363200
Schistosoma japonicum Sjp_0109890   UDP-glucuronic acid decarboxylase 1, putative
Schistosoma japonicum Sjp_0028560   ko:K01710 dTDP-glucose 4,6-dehydratase [EC4.2.1.46], putative
Schistosoma mansoni Smp_135100   dtdp-glucose 4-6-dehydratase
Schmidtea mediterranea mk4.000541.03  
Schmidtea mediterranea mk4.000541.02  
Schmidtea mediterranea mk4.000541.01   UDP-glucuronic acid decarboxylase 1
Trypanosoma cruzi TcCLB.509965.380   dTDP-glucose 4,6-dehydratase, putative
Trypanosoma cruzi TcCLB.509051.30   dTDP-glucose 4,6-dehydratase, putative
Trichomonas vaginalis TVAG_178290   NAD dependent epimerase/dehydratase, putative

Essentiality

Rv3634c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3851 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3634c (Mycobacterium tuberculosis), UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridin
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