Detailed view for Rv3667

Basic information

TDR Targets ID: 980414
Mycobacterium tuberculosis, Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (a
Source Database / ID:  Tuberculist 

pI: 5.9132 | Length (AA): 651 | MW (Da): 71444 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 648 5u29 (A) 16 673 40.00 0 1 1.47769 -0.71
3 649 5ifi (A) 18 678 44.00 0 1 1.56216 -1.08
11 651 5jrh (A) 6 645 49.00 0 1 1.65394 -1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126680)

Species Accession Gene Product
Arabidopsis thaliana AT5G36880   acetyl-CoA synthetase
Babesia bovis BBOV_II003630   acetyl-CoA synthetase, putative
Brugia malayi Bm1_47310   acetyl-Coenzyme A synthetase 2
Candida albicans CaO19.9310   similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase
Candida albicans CaO19.1064   similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase
Candida albicans CaO19.1743   similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase
Candida albicans CaO19.8666   similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase
Caenorhabditis elegans CELE_C36A4.9   Protein ACS-19, isoform B
Cryptosporidium hominis Chro.10418   acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme)
Cryptosporidium parvum cgd1_3710   acetyl-coenzyme A synthetase
Dictyostelium discoideum DDB_G0274939   hypothetical protein
Dictyostelium discoideum DDB_G0277815   acetyl-CoA ligase
Drosophila melanogaster Dmel_CG6432   CG6432 gene product from transcript CG6432-RB
Drosophila melanogaster Dmel_CG9390   Acetyl Coenzyme A synthase
Escherichia coli b0335   propionate--CoA ligase
Escherichia coli b4069   acetyl-CoA synthetase
Echinococcus granulosus EgrG_000817300   acetyl coenzyme A synthetase cytoplasmic
Echinococcus multilocularis EmuJ_000817300   acetyl coenzyme A synthetase, cytoplasmic
Homo sapiens ENSG00000111058   acyl-CoA synthetase short-chain family member 3
Homo sapiens ENSG00000131069   acyl-CoA synthetase short-chain family member 2
Homo sapiens ENSG00000154930   acyl-CoA synthetase short-chain family member 1
Leishmania braziliensis LbrM.23.0800   acetyl-CoA synthetase, putative
Leishmania braziliensis LbrM.23.0580   acetyl-CoA synthetase, putative
Leishmania infantum LinJ.23.0580   acetyl-CoA synthetase, putative
Leishmania infantum LinJ.23.0880   acetyl-CoA synthetase, putative
Leishmania major LmjF.23.0540   acetyl-CoA synthetase, putative
Leishmania major LmjF.23.0710   acetyl-CoA synthetase, putative
Leishmania mexicana LmxM.23.0540   acetyl-CoA synthetase, putative
Leishmania mexicana LmxM.23.0710   acetyl-CoA synthetase, putative
Mus musculus ENSMUSG00000027452   acyl-CoA synthetase short-chain family member 1
Mus musculus ENSMUSG00000027605   acyl-CoA synthetase short-chain family member 2
Mus musculus ENSMUSG00000035948   acyl-CoA synthetase short-chain family member 3
Mycobacterium tuberculosis Rv3667   Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (a
Mycobacterium ulcerans MUL_4241   acetyl-CoA synthetase
Neospora caninum NCLIV_039400   hypothetical protein
Neospora caninum NCLIV_032540   acetyl-coenzyme a synthetase, putative
Oryza sativa 4335745   Os04g0404800
Oryza sativa 4329518   Os02g0525900
Plasmodium berghei PBANKA_1126500   acetyl-CoA synthetase, putative
Plasmodium falciparum PF3D7_0627800   acetyl-CoA synthetase, putative
Plasmodium knowlesi PKNH_1122000   acetyl-CoA synthetase, putative
Plasmodium vivax PVX_114495   acetyl-CoA synthetase, putative
Plasmodium yoelii PY02707   acetate--CoA ligase-related
Saccharomyces cerevisiae YAL054C   acetate--CoA ligase 1
Saccharomyces cerevisiae YLR153C   acetate--CoA ligase ACS2
Schistosoma japonicum Sjp_0212080   ko:K01895 acetyl-CoA synthetase [EC6.2.1.1], putative
Schistosoma mansoni Smp_168520   acetyl-CoA synthetase
Schmidtea mediterranea mk4.002741.00   Acetyl-CoA synthetase
Schmidtea mediterranea mk4.002661.03  
Schmidtea mediterranea mk4.053754.00  
Schmidtea mediterranea mk4.000576.06  
Schmidtea mediterranea mk4.000576.04   Acyl-CoA synthetase short-chain family member 3, mitochondrial
Schmidtea mediterranea mk4.007375.04   Acyl-CoA synthetase short-chain family member 3, mitochondrial
Schmidtea mediterranea mk4.042168.00   Acyl-CoA synthetase short-chain family member 3, mitochondrial
Schmidtea mediterranea mk4.005360.01  
Schmidtea mediterranea mk4.007375.06  
Trypanosoma brucei gambiense Tbg972.8.1970   acetyl-CoA synthetase, putative
Trypanosoma brucei Tb927.8.2520   acetyl-CoA synthetase, putative
Trypanosoma congolense TcIL3000_8_2710   acetyl-CoA synthetase, putative
Trypanosoma cruzi TcCLB.509331.30   acetyl-CoA synthetase, putative
Trypanosoma cruzi TcCLB.504427.110   acetyl-CoA synthetase, putative
Toxoplasma gondii TGME49_232580   propionate-CoA ligase
Toxoplasma gondii TGME49_266640   Acetyl-coenzyme A synthetase 2, putative
Theileria parva TP04_0219   acetyl-coenzyme A synthetase, putative
Trichomonas vaginalis TVAG_005950   antibiotic synthetase, putative
Trichomonas vaginalis TVAG_433110   antibiotic synthetase, putative

Essentiality

Rv3667 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.2520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.2520 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.2520 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.2520 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b0335 Escherichia coli non-essential goodall
b4069 Escherichia coli non-essential goodall
YLR153C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1126500 Plasmodium berghei Essential plasmo
TGME49_266640 Toxoplasma gondii Probably non-essential sidik
TGME49_232580 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Yersinia pestis AMP-binding enzyme family protein 525 aa 26.5% 567 aa Compounds References
Luciola lateralis Luciferase 548 aa 22.7% 534 aa Compounds References
Photuris pennsylvanica Luciferin 4-monooxygenase 545 aa 20.9% 556 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3667 (Mycobacterium tuberculosis), Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (a
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