Detailed view for Rv3683

Basic information

TDR Targets ID: 9708
Mycobacterium tuberculosis, Conserved protein
Source Database / ID:  Tuberculist 

pI: 9.1761 | Length (AA): 319 | MW (Da): 34394 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149  
PF12850   Calcineurin-like phosphoesterase superfamily domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_131163)

Species Accession Gene Product
Brugia malayi Bm1_38285   Ser/Thr protein phosphatase family protein
Caenorhabditis elegans CELE_T23G7.2   Protein T23G7.2, isoform A
Caenorhabditis elegans CELE_F40B5.2   Protein F40B5.2, isoform A
Chlamydia trachomatis CT_461   metallophosphoesterase
Dictyostelium discoideum DDB_G0269754   hypothetical protein
Dictyostelium discoideum DDB_G0284223   hypothetical protein
Dictyostelium discoideum DDB_G0285127   hypothetical protein
Escherichia coli b0164   phosphodiesterase with model substrate bis-pNPP
Entamoeba histolytica EHI_013150   phosphoesterase, putative
Entamoeba histolytica EHI_180930   hypothetical protein
Homo sapiens ENSG00000188167   transmembrane protein with metallophosphoesterase domain
Loa Loa (eye worm) LOAG_09266   hypothetical protein
Loa Loa (eye worm) LOAG_11083   hypothetical protein
Mycobacterium leprae ML2309   conserved hypothetical protein
Mus musculus ENSMUSG00000079260   transmembrane protein with metallophosphoesterase domain
Mycobacterium tuberculosis Rv3683   Conserved protein
Mycobacterium ulcerans MUL_4258   hypothetical protein
Onchocerca volvulus OVOC4258   Putative metallophosphoesterase
Onchocerca volvulus OVOC1404   Transmembrane protein with metallophosphoesterase domain homolog
Trichomonas vaginalis TVAG_RG_DS113493_8   conserved hypothetical protein

Essentiality

Rv3683 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu3746 this record Mycobacterium tuberculosis non-essential nmpdr
b0164 Escherichia coli non-essential goodall
CELE_T23G7.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3683 (Mycobacterium tuberculosis), Conserved protein
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