pI: 6.6872 |
Length (AA): 420 |
MW (Da): 46853 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 408 | 6bqc (A) | 25 | 377 | 26.00 | 0 | 1 | 1.01277 | 0.61 |
84 | 408 | 6bqc (A) | 38 | 377 | 28.00 | 0 | 1 | 1.08901 | -0.01 |
175 | 246 | 4fzw (C) | 127 | 200 | 44.00 | 0.059 | 0.24 | 0.333729 | 0.85 |
176 | 262 | 1zq9 (A) | 41 | 127 | 23.00 | 0 | 0.98 | 0.618343 | -1.11 |
195 | 252 | 1g6q (1) | 62 | 119 | 41.00 | 0.51 | 0.95 | 0.556395 | -0.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127897)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G23470 | cyclopropane-fatty-acyl-phospholipid synthase |
Arabidopsis thaliana | AT3G23480 | Cyclopropane-fatty-acyl-phospholipid synthase |
Arabidopsis thaliana | AT3G23530 | Cyclopropane-fatty-acyl-phospholipid synthase |
Arabidopsis thaliana | AT3G23510 | cyclopropane-fatty-acyl-phospholipid synthase |
Candida albicans | CaO19.12294 | potential cyclopropane-fatty-acyl-phospholipid synthase similar to plant cyclopropane synthase (AAM33848) |
Candida albicans | CaO19.4831 | potential cyclopropane-fatty-acyl-phospholipid synthase similar to plant cyclopropane synthase (AAM33848) |
Caenorhabditis elegans | CELE_F13D12.9 | Protein F13D12.9 |
Dictyostelium discoideum | DDB_G0283847 | cyclopropane fatty acid synthase |
Dictyostelium discoideum | DDB_G0267592 | hypothetical protein |
Escherichia coli | b1661 | cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase) |
Leishmania braziliensis | LbrM.08.0590 | cyclopropane-fatty-acyl-phospholipid synthase |
Leishmania donovani | LdBPK_080560.1 | cyclopropane-fatty-acyl-phospholipid syntahse |
Leishmania infantum | LinJ.08.0560 | cyclopropane-fatty-acyl-phospholipid syntahse |
Leishmania mexicana | LmxM.08.0545 | cyclopropane-fatty-acyl-phospholipid synthase |
Loa Loa (eye worm) | LOAG_13555 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14720 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13554 | hypothetical protein |
Mycobacterium leprae | ML2334 | POSSIBLE FATTY ACID SYNTHASE |
Mycobacterium tuberculosis | Rv3720 | Possible fatty acid synthase |
Mycobacterium tuberculosis | Rv0447c | Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase) |
Mycobacterium tuberculosis | Rv0644c | Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) |
Mycobacterium tuberculosis | Rv3392c | Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac |
Mycobacterium tuberculosis | Rv0449c | Conserved hypothetical protein |
Mycobacterium ulcerans | MUL_1404 | oxidoreductase |
Mycobacterium ulcerans | MUL_0731 | methoxy mycolic acid synthase 2, MmaA2 |
Mycobacterium ulcerans | MUL_3772 | methoxy mycolic acid synthase 5 MmaA5 |
Mycobacterium ulcerans | MUL_1402 | cyclopropane-fatty-acyl-phospholipid synthase |
Oryza sativa | 4351940 | Os12g0267200 |
Oryza sativa | 4343210 | Os07g0474600 |
Onchocerca volvulus | OVOC10396 |
|
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3452 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu656 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3784 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu450 | Mycobacterium tuberculosis | non-essential | nmpdr |
b1661 | Escherichia coli | non-essential | goodall |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3
63 literature references were collected for this gene.