Detailed view for Rv3765c

Basic information

TDR Targets ID: 9952
Mycobacterium tuberculosis, PROBABLE TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN TCRX

Source Database / ID: Tuberculist / Rv3765c 

pI: 5.74 | Length (AA): 234 | MW (Da): 25844 | Number of Paralogs: 3

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00072   Response_reg
PF00486   Trans_reg_C

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003677   DNA binding  
GO:0000156   two-component response regulator activity  
Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 11
Cumulative epitope score: 12.7
Normalized epitope score: 5.4
Percentile: 80.2 (this protein belongs to the top 19.8% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_11259
Number of Paralogs: 3

Ortholog group members from selected species:
Escherichia coli K12 NP_415103.1   DNA-binding response regulator in two-component regulatory s... |   OrthoMCL
Escherichia coli K12 NP_417497.1   DNA-binding response regulator in two-component regulatory s... |   OrthoMCL
Escherichia coli K12 NP_416478.2   predicted DNA-binding response regulator in two-component sy... |   OrthoMCL
Escherichia coli K12 NP_418537.1   DNA-binding response regulator in two-component regulatory s... |   OrthoMCL
Mycobacterium leprae strain TN ML2123   TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PR... |   OrthoMCL
Mycobacterium leprae strain TN ML0174   Mycobacterial persistence regulator MrpA (two-component resp... |   OrthoMCL
Mycobacterium tuberculosis Rv0903c   TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PR... |   OrthoMCL
Mycobacterium tuberculosis Rv0981   MYCOBACTERIAL PERSISTENCE REGULATOR MRPA (TWO COMPONENT RESP... |   OrthoMCL
Mycobacterium tuberculosis Rv0757   POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSIT... |   OrthoMCL
Mycobacterium tuberculosis Rv0602c   PROBABLE TWO COMPONENT DNA BINDING TRANSCRIPTIONAL REGULATOR... |   OrthoMCL
Mycobacterium tuberculosis Rv3765c (this record).   PROBABLE TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN TC... |   OrthoMCL
Mycobacterium tuberculosis Rv1033c   TWO COMPONENT TRANSCRIPTIONAL REGULATOR TRCR... |   OrthoMCL
Trypanosoma congolense TcIL3000.0.45650   |   OrthoMCL
Wolbachia endosymbiont of Brugia malayi Wbm0596   Response regulator consisting of a CheY-like receiver domain... |   OrthoMCL

Essentiality Rv3765c has essentiality data
Gene/Ortholog: mtu997 (OG4_11259); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu772 (OG4_11259); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu611 (OG4_11259); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu3830 (OG4_11259); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: mtu1050 (OG4_11259); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco559 (OG4_11259); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco559 (OG4_11259); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco559 (OG4_11259); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco559 (OG4_11259); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco2923 (OG4_11259); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco2923 (OG4_11259); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco2923 (OG4_11259); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco2923 (OG4_11259); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco3958 (OG4_11259); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco3958 (OG4_11259); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3958 (OG4_11259); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3958 (OG4_11259); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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