Detailed view for Rv3807c

Basic information

TDR Targets ID: 980244
Mycobacterium tuberculosis, Possible conserved transmembrane protein
Source Database / ID:  Tuberculist 

pI: 12.2861 | Length (AA): 165 | MW (Da): 17218 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01569  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 164 1d2t (A) 51 220 16.00 0.77 0.13 1.041 0.44
42 146 5b8h (A) 47 180 40.00 0.00072 0.21 0.543564 2.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130600)

Species Accession Gene Product
Arabidopsis thaliana AT4G22550   phosphatidic acid phosphatase (PAP2) family protein
Brugia malayi Bm1_33880   PAP2 superfamily protein
Caenorhabditis elegans CELE_T13C5.6   Protein T13C5.6
Drosophila melanogaster Dmel_CG31717   CG31717 gene product from transcript CG31717-RA
Echinococcus granulosus EgrG_000466200   phosphatidic acid phosphatase type 2
Echinococcus multilocularis EmuJ_000466200   phosphatidic acid phosphatase type 2
Homo sapiens ENSG00000205808   phosphatidic acid phosphatase type 2 domain containing 2
Loa Loa (eye worm) LOAG_00360   hypothetical protein
Mycobacterium leprae ML0094   Possible conserved transmembrane protein
Mus musculus ENSMUSG00000040105   phosphatidic acid phosphatase type 2 domain containing 2
Mycobacterium tuberculosis Rv3807c   Possible conserved transmembrane protein
Mycobacterium tuberculosis Rv0308   Probable conserved integral membrane protein
Mycobacterium ulcerans MUL_4991   transmembrane protein
Mycobacterium ulcerans MUL_1222   integral membrane protein
Oryza sativa 4330224   Os02g0661800
Onchocerca volvulus OVOC2625  
Schistosoma mansoni Smp_173120   phosphatidic acid phosphatase type 2-related
Schmidtea mediterranea mk4.000240.02   AT30094p
Treponema pallidum TP0551   phosphatase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3807c (Mycobacterium tuberculosis), Possible conserved transmembrane protein
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