Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1313 | 0.4114 |
Brugia malayi | glutathione reductase | 0.0091 | 0.2693 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0023 | 0.0211 | 0.0783 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0031 | 0.0517 | 0.0716 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0031 | 0.0517 | 0.0716 |
Treponema pallidum | NADH oxidase | 0.0031 | 0.0517 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0031 | 0.0517 | 0.0716 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0031 | 0.0517 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.023 | 0.7805 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0031 | 0.0517 | 0.0716 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0031 | 0.0517 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0207 | 0.6957 | 0.8837 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0031 | 0.0517 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0091 | 0.2693 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0031 | 0.0517 | 0.5 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0023 | 0.0211 | 0.0783 |
Brugia malayi | Thioredoxin reductase | 0.0091 | 0.2693 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Plasmodium falciparum | glutathione reductase | 0.0091 | 0.2693 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0031 | 0.0517 | 0.0716 |
Trypanosoma brucei | trypanothione reductase | 0.0091 | 0.2693 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0091 | 0.2712 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0031 | 0.0517 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0207 | 0.6957 | 0.8837 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0031 | 0.0517 | 0.0716 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0031 | 0.0517 | 0.0716 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0091 | 0.2693 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0091 | 0.2693 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.023 | 0.7805 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0091 | 0.2693 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0091 | 0.2693 | 0.2985 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0091 | 0.2712 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0031 | 0.0517 | 0.0716 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0031 | 0.0517 | 0.0716 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0031 | 0.0517 | 0.0716 |
Toxoplasma gondii | thioredoxin reductase | 0.0091 | 0.2693 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0031 | 0.0517 | 0.0716 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0031 | 0.0517 | 0.0716 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0207 | 0.6957 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0031 | 0.0517 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0031 | 0.0517 | 0.0716 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0207 | 0.6957 | 0.8837 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1313 | 0.4878 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0696 | 0.0189 |
Leishmania major | trypanothione reductase | 0.0091 | 0.2693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0696 | 0.1481 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0031 | 0.0517 | 0.1921 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0207 | 0.6957 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0091 | 0.2693 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0031 | 0.0517 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0031 | 0.0517 | 0.0716 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0349 | 0.1298 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1313 | 0.4878 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0031 | 0.0517 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.023 | 0.7805 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1313 | 0.4114 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.023 | 0.7805 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0091 | 0.2693 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0207 | 0.6957 | 0.8837 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0031 | 0.0517 | 0.0716 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0696 | 0.2586 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0031 | 0.0517 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0031 | 0.0517 | 0.0716 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 4.03 uM | Cytotoxicity against human MDA-MB-231 cells ATCC HTB26 after 72 hrs by sulforhodamine B assay | ChEMBL. | 18763756 |
GI50 (functional) | = 4.68 uM | Cytotoxicity against human A549 cells ATCC CCL185 after 72 hrs by sulforhodamine B assay | ChEMBL. | 18763756 |
GI50 (functional) | = 4.94 uM | Cytotoxicity against human HT29 cells ATCC HTB38 after 72 hrs by sulforhodamine B assay | ChEMBL. | 18763756 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.