Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | M18 aspartyl aminopeptidase | 0.0075 | 0.3032 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0075 | 0.3032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3032 | 0.2291 |
Plasmodium vivax | M18 aspartyl aminopeptidase, putative | 0.0075 | 0.3032 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MH, Family M20 | 0.0075 | 0.3032 | 0.5 |
Loa Loa (eye worm) | aspartyl aminopeptidase | 0.0075 | 0.3032 | 0.2291 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0075 | 0.3032 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0075 | 0.3032 | 1 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0075 | 0.3032 | 0.4632 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0075 | 0.3032 | 0.4632 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5735 | 0.5282 |
Brugia malayi | Aspartyl aminopeptidase | 0.0075 | 0.3032 | 1 |
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.0075 | 0.3032 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.9698 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3032 | 0.2291 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.8874 | 0.8754 |
Trypanosoma cruzi | aspartyl aminopeptidase, putative | 0.0075 | 0.3032 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0075 | 0.3032 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0075 | 0.3032 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0107 | 0.5433 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.0075 | 0.3032 | 0.5 |
Leishmania major | aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 | 0.0075 | 0.3032 | 0.5 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0075 | 0.3032 | 0.5 |
Echinococcus granulosus | aspartyl aminopeptidase | 0.0075 | 0.3032 | 1 |
Echinococcus multilocularis | aspartyl aminopeptidase | 0.0075 | 0.3032 | 0.2371 |
Entamoeba histolytica | aspartyl aminopeptidase, putative | 0.0075 | 0.3032 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 245 nM | Inhibition of [131I]DCIT from PSMA in human LNCAP cells | ChEMBL. | 19111054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.