Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.1446 | 0.3315 | 0.4657 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.2016 | 0.4925 | 0.5133 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.367 | 0.9594 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.367 | 0.9594 | 1 |
Entamoeba histolytica | hypothetical protein | 0.057 | 0.0841 | 0.0877 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0479 | 0.0585 | 0.5 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.0842 | 0.1609 | 0.1677 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.2016 | 0.4925 | 0.5133 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.2016 | 0.4925 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.367 | 0.9594 | 1 |
Brugia malayi | WGR domain containing protein | 0.367 | 0.9594 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.1744 | 0.4156 | 0.4332 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.2016 | 0.4925 | 1 |
Leishmania major | DNA repair protein, putative | 0.0479 | 0.0585 | 0.5 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.057 | 0.0841 | 0.0877 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.114 | 0.245 | 0.2554 |
Onchocerca volvulus | DNA ligase 3 homolog | 0.0479 | 0.0585 | 1 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.057 | 0.0841 | 0.0877 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2016 | 0.4925 | 0.6917 |
Brugia malayi | WGR domain containing protein | 0.2016 | 0.4925 | 0.5133 |
Echinococcus granulosus | WGR domain containing protein | 0.114 | 0.245 | 0.2554 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.057 | 0.0841 | 0.0877 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.367 | 0.9594 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2793 | 0.712 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.0585 | 0.0821 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.2016 | 0.4925 | 0.5133 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.2016 | 0.4925 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli at 50 ug/disk | ChEMBL. | 18729518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.