Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coactivator-associated arginine methyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1675 | 0.1675 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0735 | 0.0829 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0993 | 0.0969 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.3401 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1675 | 0.1416 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1317 | 0.1047 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.3401 | 0.24 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1675 | 0.1675 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0301 | 0.0301 |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.3401 | 0.3196 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0993 | 0.1121 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0074 | 0.3401 | 0.3401 |
Onchocerca volvulus | 0.014 | 0.8861 | 1 | |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.3401 | 0.24 |
Loa Loa (eye worm) | Carm1-pending protein | 0.0154 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.3401 | 0.24 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.3401 | 1 |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.3401 | 0.3196 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0735 | 0.0735 |
Brugia malayi | Heterochromatin protein 1 | 0.0074 | 0.3401 | 0.3196 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0154 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1675 | 0.1416 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1317 | 0.1047 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.3401 | 0.24 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.0735 | 0.0447 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0154 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0993 | 0.0969 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1317 | 0.1317 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1317 | 0.1047 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0154 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1317 | 0.1047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.9 uM | Inhibition of human GST-tagged CARM1 by methylation assay | ChEMBL. | 18619839 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.