Detailed view for EmuJ_000421400

Basic information

TDR Targets ID: 962448
Echinococcus multilocularis, histone arginine methyltransferase CARMER
Source Database / ID:  GeneDB

pI: 5.6907 | Length (AA): 659 | MW (Da): 71774 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06325   Ribosomal protein L11 methyltransferase (PrmA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0006479   protein amino acid methylation  

Metabolic Pathways

Endocrine resistance (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
109 512 5lkj (A) 136 496 63.00 0 1 1.25445 -0.47
147 251 2esr (A) 29 136 24.00 0 0.89 0.478932 -0.57
156 234 3dmg (A) 230 307 31.00 0 0.97 0.449479 0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131706)

Species Accession Gene Product
Arabidopsis thaliana AT3G06930   arginine methyltransferase 4B
Arabidopsis thaliana AT5G49020   protein arginine methyltransferase 4A
Brugia malayi Bm1_42010   Carm1-pending protein
Drosophila melanogaster Dmel_CG5358   Arginine methyltransferase 4
Echinococcus granulosus EgrG_000421400   histone arginine methyltransferase CARMER
Echinococcus multilocularis EmuJ_000421400   histone arginine methyltransferase CARMER
Homo sapiens ENSG00000142453   coactivator-associated arginine methyltransferase 1
Loa Loa (eye worm) LOAG_08544   Carm1-pending protein
Mus musculus ENSMUSG00000032185   coactivator-associated arginine methyltransferase 1
Neospora caninum NCLIV_001020   Protein arginine methyltransferase, related
Oryza sativa 4344248   Os07g0671700
Onchocerca volvulus OVOC10781  
Schistosoma japonicum Sjp_0032050   ko:K05931 Arginine methyltransferase 4 [EC:2.1.1.125], putative
Schistosoma mansoni Smp_070340   protein arginine n-methyltransferase
Schmidtea mediterranea mk4.002107.06  
Toxoplasma gondii TGME49_294270   histone arginine methyltransferase PRMT4/CARM1

Essentiality

EmuJ_000421400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_294270 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus coactivator-associated arginine methyltransferase 1 Compounds References
Homo sapiens coactivator-associated arginine methyltransferase 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Emericella nidulans RmtA 345 aa 31.5% 355 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0425 1 0.5
0.1062 1 1
0.0392 1 1
0.0732 1 0.5
0.084 0.3058 0.3056
0.053 0.7715 0.7706
0.0956 0.6635 0.6635
0.0687 0.3405 0.3796
0.0154 1 0.5
0.0267 1 0.5
0.0154 1 0.5
0.0386 1 1
0.051 0.7063 0.7061
0.0154 1 0.5
0.0506 0.3575 0.3573
0.0154 1 0.5
0.0257 0.2752 0.2752
0.0154 1 0.5
0.0415 1 0.5
0.0258 0.6579 0.6579
0.3529 1 1
0.268 1 1
0.082 0.3364 0.3364
0.262 1 1
0.0447 1 1
0.3467 0.5994 1
0.0128 0.2916 0.2905
0.354 1 1
0.0894 0.5363 0.5359
0.0152 1 1
0.0133 0.5026 0.5026
0.3467 0.5994 1
0.0382 0.4728 0.4728
0.0154 1 0.5
0.0374 1 1
0.0406 0.6387 1
0.0175 1 1
0.0125 0.3603 0.3603
0.0252 0.3529 0.3503
0.0154 1 0.5
0.0649 0.9425 0.9421
0.0378 0.5319 0.5319
0.0175 0.2764 0.5
0.3549 1 1
0.2733 1 1
0.3467 0.5994 1
0.0511 0.3586 0.3583
0.0128 0.3218 0.3218
0.0382 0.5317 0.5317
0.0125 0.3603 0.3603
0.1709 1 1
0.0687 0.3405 0.3796
0.0689 0.3402 0.4128
0.0124 0.4586 1
0.0154 1 0.5
0.0124 0.7207 0.7207
0.2858 1 0.5
0.0154 0.3027 0.8453
0.0154 1 0.5
0.0389 0.3971 0.3971
0.0154 1 0.5
0.0134 0.7544 0
0.0124 0.5197 0.5197
0.0262 0.4427 0.442
0.013 1 0.5
0.0859 1 1
0.2068 1 0.5
0.0154 1 0.5
0.1149 1 1
0.0175 1 1
0.0725 1 0.5
0.0154 1 0.5
0.0124 0.5197 0.5197
0.0182 1 1
0.0386 0.3498 0.6552
0.0146 0.2809 0.4021
0.0425 0.3118 0.3118
0.2786 1 1
0.0154 1 0.5
0.0425 1 0.5
0.0852 0.3772 0.4097
0.0171 0.3202 0.3199
0.0142 0.5074 0.5074
0.1093 1 1
0.0154 1 0.5
0.0257 0.4557 0.6452
0.0154 1 1
0.3467 0.5994 1
0.0712 0.8518 0.8518
0.018 0.7057 1
0.0154 0.8047 0.8047
0.0885 1 1
0.1084 1 1
0.344 1 1
0.0685 1 1
0.0415 1 0.5
0.314 1 1
0.0894 0.5363 0.5359
0.0082 1 1
0.0382 0.2527 0.3758
0.0154 0.5 0.5
0.0687 0.3405 0.3796
0.0263 0.3086 0.3086
0.0844 1 1
0.0582 1 0.5
0.0154 1 0.5
0.082 0.3364 0.3364
0.0153 1 0.5
0.0269 1 0.5
0.0154 0.332 0.332
0.0154 1 0.5
0.0131 1 1
0.0126 0.3155 0.3093
0.0124 0.7207 0.7207
0.1315 1 1
0.0175 1 1
0.343 1 1
0.0504 1 0.5
0.0431 1 0.5
0.356 1 1
0.058 0.6946 0.6946
0.0722 1 1
0.0154 1 0.5
0.0154 1 0.5
0.0175 1 1
0.0141 1 0.5
0.3138 1 1
0.0126 0.3242 0.3242
0.3467 0.5994 1
0.0134 0.7544 0
0.0127 0.5312 0.5312
0.0248 1 1
0.0126 0.3182 0.3182
0.0258 0.6255 0.6253
0.0126 1 1
0.0129 0.3183 0.3183
0.0844 1 1
0.1073 1 1
0.0154 1 0.5
0.1921 1 1
0.2694 0.6575 0.6575
0.1279 0.2834 0.6869
0.3303 1 1
0.0438414 1 1
0.0124 0.5167 0.6418
0.0154 0.8682 0.8577
0.052 0.3632 0.3632
0.0425 0.3118 0.3118
0.0154 1 0.5
0.0175 1 1
0.308 1 1
0.0376 0.7299 1
0.1073 1 1
0.0134 0.7544 0
0.018 0.7057 1
0.0175 1 0.5
0.1274 1 1
0.0081 0.2689 0.4225
0.0376 0.7299 1
0.0386 1 1
0.0154 1 1
0.0154 1 0.5
0.0382 0.2527 0.3758
0.0982 1 1
0.0124 0.5197 0.5197
0.0533095 0.294613 1
0.0627 0.7631 0.763
0.0263 0.3086 0.3086
0.2995 1 0.5
0.097 1 1
0.0722 0.8075 0.8075
0.0154 0.4817 0.4809
0.0632 0.4265 0.4242
0.2162 0.5418 0.6187
0.0631 1 1
0.0288 1 1
0.0404 1 1
0.0154 1 0.5
0.0655 1 0.5
0.0837 1 0.5
0.3471 1 1
0.0131 0.3247 0.3247
0.0128 0.4933 0.4483
0.268 1 1
0.0154 1 0.5
0.038 1 1
0.0676 0.5898 0.7737
0.013 0.4633 0.58
0.0126 1 0.5
0.0154 1 0.5
0.0154 1 0.5
0.053 0.7715 0.7706
0.0154 1 0.5
0.1106 1 1
0.0433 1 0.5
0.0844 1 1
0.0706 0.4763 0.4758
0.153 0.3827 0.3827
0.099 0.6389 1
0.0931 1 1
0.0196 1 1
0.0135 0.4183 0.3514
0.2162 0.5418 0.6187
0.0115 0.3391 0.5198
0.0673 0.2775 0.8218
0.3579 1 1
0.3213 1 1
0.0686 1 0.5
0.0166 1 1
0.3467 0.5994 1
0.1953 1 1
0.0154 1 0.5
0.0154 1 0.5
0.0147 0.3552 0.3469
0.0154 1 0.5
0.0154 1 0.5
0.3273 1 1
0.0195 0.3938 0.5
0.2797 1 0.5
0.0154 0.4056 0.4056
0.2162 0.5418 0.6187
0.0425 1 0.5
0.0375 0.3193 0.462
0.0154 0.2702 0.4316
0.0542 0.4759 0.6254
0.0154 0.4817 0.4809
0.0175 1 1
0.0542 1 0.5
0.0081 0.2689 0.4225
0.058 0.6946 0.6946
0.0154 1 0.5
0.0124 0.3172 0.3172
0.0163 0.2892 0.5431
0.0509 0.7082 0.7082
0.0126 1 1
0.2162 0.5418 0.6187
0.3467 0.5994 1
0.0254 1 1
0.0947 0.6702 0.6701
0.0689 0.3402 0.4128
0.0857 0.542 0.9333
0.051 0.7063 0.7061
0.0195 0.3938 0.5
0.0124 1 0.5
0.0154 1 0.5
0.0271 0.2524 0.3206
0.0377 0.4884 0.5229
0.0197 1 0.5
0.0425 0.3118 0.3118
0.1919 1 1
0.0249 0.3158 0.6461
0.026 0.4335 0.4335
0.0402 0.4699 0.4699
0.0154 0.7179 0.7171
0.0514 0.7079 0.7079
0.0126 0.3155 0.3093
0.0501 1 1
0.1149 1 1
0.104 1 1
0.0154 1 0.5
0.00730405 0.497396 1
0.0154 1 0.5
0.0254 0.3506 0.3502
0.0154 1 0.5
0.0128 0.2501 0.5087
0.0151 1 1
0.0712 0.8518 0.8518
0.2694 0.6575 0.6575

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EmuJ_000421400 (Echinococcus multilocularis), histone arginine methyltransferase CARMER
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