Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | GPI-anchor transamidase subunit 8 (GPI8) | 0.0948 | 0.2184 | 0.5 |
Plasmodium falciparum | GPI-anchor transamidase, putative | 0.0948 | 0.2184 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0321 | 0.0622 | 0.0483 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.4085 | 1 | 1 |
Onchocerca volvulus | Legumain homolog | 0.4085 | 1 | 0.5 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.4085 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.046 | 0.097 | 0.0471 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0275 | 0.0508 | 1 |
Brugia malayi | GPI-anchor transamidase | 0.0948 | 0.2184 | 0.1752 |
Brugia malayi | glutaminase DH11.1 | 0.0321 | 0.0622 | 0.0104 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0281 | 0.0523 | 0.0382 |
Schistosoma mansoni | glycosylphosphatidylinositol:protein transamidase (C13 family) | 0.0948 | 0.2184 | 0.2184 |
Schistosoma mansoni | hypothetical protein | 0.3137 | 0.7638 | 0.7638 |
Echinococcus multilocularis | serotonin receptor | 0.013 | 0.0146 | 0.067 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.4085 | 1 | 1 |
Echinococcus granulosus | GPI anchor transamidase | 0.0948 | 0.2184 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.013 | 0.0146 | 0.067 |
Leishmania major | GPI-anchor transamidase subunit 8 (GPI8), putative | 0.0948 | 0.2184 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.4085 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.013 | 0.0146 | 0.067 |
Schistosoma mansoni | glutaminase | 0.0321 | 0.0622 | 0.0622 |
Schistosoma mansoni | family C13 non-peptidase homologue (C13 family) | 0.4085 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0948 | 0.2184 | 0.1665 |
Giardia lamblia | GPI-anchor transamidase, putative | 0.0948 | 0.2184 | 0.5 |
Plasmodium vivax | GPI-anchor transamidase, putative | 0.0948 | 0.2184 | 0.5 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.4085 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0948 | 0.2184 | 0.1665 |
Schistosoma mansoni | hemoglobinase (C13 family) | 0.4085 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.4085 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.4085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.048 | 0.0338 |
Loa Loa (eye worm) | glutaminase 2 | 0.0321 | 0.0622 | 0.0483 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.4085 | 1 | 1 |
Entamoeba histolytica | GPI-anchor transamidase, putative | 0.0948 | 0.2184 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.013 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | peptidase C13 family protein | 0.4085 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CD, family C13, putative | 0.0948 | 0.2184 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0275 | 0.0508 | 0.816 |
Toxoplasma gondii | peptidase c13 family protein | 0.0948 | 0.2184 | 1 |
Trichomonas vaginalis | Clan CD, family C13, legumain-like cysteine peptidase | 0.0948 | 0.2184 | 0.1665 |
Echinococcus multilocularis | GPI anchor transamidase | 0.0948 | 0.2184 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0948 | 0.2184 | 0.2068 |
Mycobacterium ulcerans | glutaminase | 0.0321 | 0.0622 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 22.04 ug ml-1 | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected human erythrocytes assessed by [3H]hypoxanthine uptake | ChEMBL. | 3298551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.